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Erschienen in: Rheumatology International 1/2016

01.01.2016 | Original Article - Imaging

[18F]fluorodeoxyglucose uptake as a predictor of large joint destruction in patients with rheumatoid arthritis

verfasst von: Yukio Yonemoto, Koichi Okamura, Kimihiko Takeuchi, Tetsuya Kaneko, Tsutomu Kobayashi, Chisa Okura, Yoshito Tsushima, Kenji Takagishi

Erschienen in: Rheumatology International | Ausgabe 1/2016

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Abstract

The present retrospective study investigated the relationship between [18F]fluorodeoxyglucose–positron emission tomography (FDG-PET) findings and subsequent progression of joint destruction on plain X-ray. Nineteen rheumatoid arthritis (RA) patients (59 joints) who underwent FDG-PET and whose joints could be evaluated on plain X-ray 5 years later were included in this retrospective investigation. The relationship between the standardized uptake value (SUV) on FDG-PET and Larsen grade progression on plain X-ray was investigated for each joint. Factors related to progression of joint destruction were also investigated. Joints with advanced joint destruction (Larsen grades IV and V) on X-ray imaging at the time of FDG-PET were excluded. On initial plain X-ray images taken at the time of FDG-PET, a significant correlation was observed between the initial SUV of each joint and the progression of joint destruction 5 years later (R = 0.47, P < 0.01). Significant correlations between the SUV and progression of joint destruction were observed in both load-bearing (R = 0.52, P < 0.01) and non-load-bearing joints (R = 0.52, P < 0.01). On logistic regression analysis, higher SUV and lower prednisolone dose were associated with greater risk of progressive joint destruction (P < 0.05). On receiver operating characteristics curve analysis, the optimum threshold for identifying preceding joint destruction was an SUVmean of 1.33. In RA joints, FDG uptake was seen mostly by inflammatory cells; therefore, FDG uptake reflected joint inflammation. Additionally, the activity seen on FDG-PET might be associated with future radiographic changes in RA patients.
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Metadaten
Titel
[18F]fluorodeoxyglucose uptake as a predictor of large joint destruction in patients with rheumatoid arthritis
verfasst von
Yukio Yonemoto
Koichi Okamura
Kimihiko Takeuchi
Tetsuya Kaneko
Tsutomu Kobayashi
Chisa Okura
Yoshito Tsushima
Kenji Takagishi
Publikationsdatum
01.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 1/2016
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-015-3331-0

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