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10.11.2017 | Original Article | Ausgabe 3/2018

¹⁸F–fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment

Zeitschrift:: European Journal of Nuclear Medicine and Molecular Imaging > Ausgabe 3/2018

Autoren:: Pil Soo Sung, Hye Lim Park, Keungmo Yang, Seawon Hwang, Myeong Jun Song, Jeong Won Jang, Jong Young Choi, Seung Kew Yoon, Ie Ryung Yoo, Si Hyun Bae

Ergänzende Inhalte

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Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://doi.org/10.1007/s00259-017-3871-5) contains supplementary material, which is available to authorized users.

Pil Soo Sung and Hye Lim Park contributed equally to this work.

Abstract

Purpose

Sorafenib, an oral multikinase inhibitor, is a recommended treatment option available for patients with Barcelona Clinic Liver Cancer (BCLC)-C stage hepatocellular carcinoma (HCC). This study aimed to evaluate the performance of ¹⁸F–fluorodeoxyglucose positron emission tomography (¹⁸F–FDG PET) for predicting tumour progression during sorafenib treatment.

Methods

We formed a retrospective cohort comprising patients treated with sorafenib for at least 30 days and undergoing ¹⁸F–FDG PET/CT within 1 month before treatment. For statistical analyses, the tumour-to-liver standardised uptake value (SUV) ratio (TLR) of the most hypermetabolic lesion was measured.

Results

Among a total of 35 patients, two obtained partial remission, and 11 showed stable disease after the first response evaluation. Patients with a TLR ≥ 2.9 (n = 17) had a median overall survival (OS) of 3.7 months after sorafenib treatment, whereas patients with a TLR < 2.9 (n = 18) had median OS of 12.2 months (P < 0.001), although the disease control rate was not significantly different between the two groups. Pretreatment TLR ≥ 2.9 (hazard ratio [HR] = 6.318, P = 0.002) and Child-Pugh class B (HR = 4.316, P = 0.044) were poor prognostic factors for OS, and a TLR ≥ 2.9 (HR = 2.911, P = 0.024) was the only poor prognostic factor for progression-free survival in a multivariate analysis.

Conclusion

Pretreatment tumour metabolic activity assessed by ¹⁸F–FDG PET is an independent prognostic factor for survival in patients with BCLC-C stage HCC receiving sorafenib monotherapy, although it may not predict tumour response to the treatment.

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Titel: 18F–fluorodeoxyglucose uptake of hepatocellular carcinoma as a prognostic predictor in patients with sorafenib treatment
Autoren:: Pil Soo Sung
Hye Lim Park
Keungmo Yang
Seawon Hwang
Myeong Jun Song
Jeong Won Jang
Jong Young Choi
Seung Kew Yoon
Ie Ryung Yoo
Si Hyun Bae
Publikationsdatum: 10.11.2017
DOI: https://doi.org/10.1007/s00259-017-3871-5
Verlag: Springer Berlin Heidelberg
Zeitschrift: European Journal of Nuclear Medicine and Molecular Imaging
Ausgabe 3/2018
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089

Sie können e.Med Radiologie 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.
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Electronic supplementary material

Abstract

Purpose

Methods

Results

Conclusion

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