P349 Muscle mitochondrial function and N+/K+ -ATPase activity are unaffected by sepsis in pigs
M Von Seth, L Hillered, A Otterbeck, K Hanslin, A Larsson, J Sjölin, M Lipcsey
Uppsala University, Uppsala, Sweden
P350 Pilot study showing reduced bone strength at 96 hours in rodent sepsis
ME Cove1, NS Chew2, LH Vu2, RZ Lim2, Z Puthucheary3
1National University Hospital, Singapore, Singapore; 2Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore; 3University College London, London, United Kingdom
P351 Endotoxin clearance by the spleen is unaffected by pre-existing systemic inflammation in porcine septic shock
K Hanslin1, F Wilske2, P Skorup2, E Tano2, J Sjölin2, M Lipcsey1
1Uppsala University, Uppsala, Sweden; 2Uppsala University, Department of Medical Sciences, Uppsala, Sweden
P352 The role of autophagy in critical illness-induced organ failure
I Derese, S Thiessen, S Derde, T Dufour, L Pauwels, Y Bekhuis, G Van den Berghe, I Vanhorebeek
University Hospital, Leuven, Belgium
P353 Role of leptin and proprotein convertase subtilisin/kexin type 9 in modulating pulmonary inflammation in a murine model of early sepsis
M Khan1, D Dwivedi1, J Zhou1, A Prat2, NG Seidah2, PC Liaw1, AE Fox-Robichaud1
1McMaster University, Hamilton, Canada; 2Montreal Clinical Research Institute, Montreal, Canada
P354 The role of oxygen delivery on plasma lactate and organ failure in experimental septic shock
M Von Seth, P Skorup, L Hillered, A Larsson, J Sjölin, M Lipcsey
Uppsala University, Uppsala, Sweden
P355 The lung is not a significant source of lactate in a pig model of sepsis
A Otterbeck, K Hanslin, M Lipcsey, A Larsson, M Von Seth
Uppsala Universitet, Uppsala, Sweden
P356 Association between inflammation, mitochondrial function and lactate clearance
T Correa1, J Pereira1, J Takala2, S Jakob2
1Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
P357 Dynamics of endotoxin, interleukin-6 and organ dysfunction after treatment with antibiotics in an E.coli porcine intensive care sepsis model
P Skorup1, L Maudsdotter2, E Tano1, M Lipcsey3, M Castegren1, A Larsson1, J Sjölin1
1Dept. of Medical Sciences, Uppsala, Sweden; 2Dept. of Molecular Biosciences, Stockholm, Sweden; 3Dept. of Surgical Sciences, Uppsala, Sweden
P358 Persisitent shift of th1 to th2 in one week after diagnosis of community-acquired severe sepsis predicts mortality
M Xue, JY Xu, L Liu, YZ Huang, FM Guo, Y Yang, HB Qiu
Southeast University, Nanjing, China
P359 Genetic variants of intron region of aquaporin AQP5 gene and development of pulmonary edema in lung infection complicated by septic shock
A Kuzovlev, V Moroz, A Goloubev, A Myazin, A Chumachenko, V Pisarev
V.A. Negovsky Research Institute of General Reanimatology, Moscow, Russia
P360 Withdrawn
P361 Altered T cell repertoire diversity and increased PD-1 expression predict mortality in patients with septic shock
N Takeyama, M Tsuda, H Kanou, R Aoki, Y Kajita, M Hashiba, T Terashima, A Tomino
Aichi Medical University, Aichi, Japan
P362 Vasopressin alone and with noradrenaline attenuates TNF-α production in an in-vitro model of monocyte priming and deactivation
R Davies, KP O´Dea, S Soni, JK Ward, DJ O´Callaghan, M Takata, AC Gordon
Imperial College, London, United Kingdom
P363 Relationship between lymphocyte subset expression and serum concentrations of pd-1/pd-l1 in sepsis – pilot study
J Wilson1, Y Zhao1, M Singer2, J Spencer1, M Shankar-Hari1
1King’s College London, London, United Kingdom; 2Bloomsbury Institute of Intensive Care Medicine, London, United Kingdom
P364 Pcsk9 loss-of-function genotype is associated with better short and long-term outcomes in sepsis
K Roveran Genga1, C Lo1, M S. Cirstea1, K R. Walley1, J A. Russell1, A Linder2, J H. Boyd1
1Center for Heart Lung Innovation - University of British Columbia (UBC), Vancouver, Canada; 2Lund University, Lund, Sweden
P365 Monocyte surface marker expression profile and cytokine secretion of critically ill patients with pseudomonas aeruginosa induced sepsis
A Sedlag1, C Riedel1, M Georgieff2, E Barth2, H Bracht2, A Essig2, D Henne-Bruns2, F Gebhard2, K Orend2, M Halatsch2, M Weiss2
1University, Ulm, Germany; 2University Hospital Medical School, Ulm, Germany
P366 Identification of a distinct metabolomic profile in acute influenza infection
M Chase1, E Freinkman2, A Uber1, X Liu1, MN Cocchi1, MW Donnino1
1Beth Israel Deaconess Medical Center, Boston, MA, United States; 2Whitehead Institute, Cambridge, MA, United States
P367 Von Willebrand factor and ADAMTS-13 influence the outcome of s. aureus bacteremia
M Peetermans1, L Liesenborghs2, J Claes2, T Vanassche2, M Hoylaerts2, M Jacquemin2, K Vanhoorelbeke2, S De Meyer2, P Verhamme1
1UZ Leuven, Leuven, Belgium; 2KU Leuven, Leuven, Belgium
P368 Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia
A Vögeli1, M Ottiger1, M Meier1, C Steuer1, L Bernasconi1, A Huber1, M Christ-Crain2, C Henzen3, C Hoess4, R Thomann5, W Zimmerli3, B Müller1, P Schütz1
1Kantonsspital Aarau, Aarau, Switzerland; 2University Hospital Basel, Basel, Switzerland; 3Kantonsspital Luzern, Lucerne, Switzerland; 4Kantonsspital Münsterlingen, Münsterlingen, Switzerland; 5Bürgerspital Solothurn, Solothurn, Switzerland
P369 Decreased functional protein c levels may be predictive of the severity of sepsis associated coagulopathy and DIC
D Hoppensteadt1, A Walborn1, M Rondina2, K Tsuruta3, J Fareed1
1Loyola University, Chicago, IL, United States; 2University of Utah School of Medicine, Eccles Institute of Human Genetics, Salt Lake City, UT, United States; 3Asahi Kasei Pharma America Corporation, Waltham, United Kingdom
P370 Cholesterol is a marker of multiple organ dysfunction syndromes after abdominal surgeries.
S Tachyla
Mogilev Regional Hospital, Mogilev, Belarus
P371 Relationship between white blood cell count and sepsis-related biomarkers in critically ill patients
T Ikeda, S Ono, T Ueno, S Suda, T Nagura
Hachiouji medical center, Tokyo medical university, Tokyo, Japan
P372 Neutrophil-lymphocyte ratio and mortality during critical illness
E Damiani, R Domizi, C Scorcella, S Tondi, S Pierantozzi, S Ciucani, N Mininno, E Adrario, P Pelaia, A Donati
Università Politecnica delle Marche, Ancona, Italy
P373 Leukocyte activity assessment using magnetic levitation in septic patients
M Schou Andersen1, S Lu1, G Lopez1, AT Lassen2, I Ghiran1, NI Shapiro1
1Beth Israel Deaconess Medical Center, Boston, MA, United States; 2Odense University Hospital, Odense, Denmark
P374 Intensive care patients undergoing tracheostomy have different patterns of cytokine and biomarker response
U Trahtemberg1, S Sviri1, M Beil2, Z Agur3, P Van Heerden1
1Hadassah University Hospital, Jerusalem, Israel; 2Marienhaus-Kliniken, Saarlouis, Germany; 3IMBM, Bene Ataroth, Israel
P375 The h3 haplotype of the EPCR gene determines high sEPCR levels in critically-ill patients
E Jahaj1, A Vassiliou1, Z Mastora1, SE Orfanos2, A Kotanidou1
1Medical School of Athens University, Evangelismos, Athens, Greece; 2Medical School of Athens University, “Attikon” Hospital, Athens, Greece
P376 The vasopressin surrogate marker copeptin reflects stress and predicts adverse clinical outcomes in unselected emergency patients: results of a multinational prospective cohort study
Y Wirz1, R Sager1, D Amin2, A Amin2, S Haubitz1, P Hausfater3, A Huber1, A Kutz1, B Mueller1, P Schuetz1
1Kantonsspital Aarau, Aarau, Switzerland; 2Morton Plant Hospital, Clearwater, FL, United States; 3Pitié-Salpêtrière, Paris, France
P377 The association of admission procalcitonin levels and adverse clinical outcome across different medical emergency patient populations: results from the multi-national, prospective, observational TRIAGE study
RS Sager1, YW Wirz1, DA Amin2, AA Amin2, PH Hausfater3, AH Huber1, S Haubitz1, A Kutz1, B Mueller1, P Schuetz1
1University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland; 2Morton Plant Hospital, Clearwater, FL, United States; 3Groupe Hospitalier Pitié-Salpêtrière, Paris, France
P378 Procalcitonin level in klebsiella pneumoniae MDR infections in icu
L Gottin, C Dell´amore, G Stringari, G Cogo, M Ceolagraziadei, M Sommavilla, F Soldani, E Polati
University Hospital, Verona, Italy
KPCG (53pts) | CG (80pts) | p | |
---|---|---|---|
AGE (years) | 63.1 ± 18.3 | 65.3 ± 16.4 | NS |
Gender (M/F) | 35/18 | 46/34 | NS |
ICU LOS (days) | 30.9 ± 33.4 | 16 ± 15.7 | <0.01 |
SOFA | 6 ± 4.4 | 6.9 ± 4.6 | NS |
Mortality (%) | 25 (47.2) | 33 (41.2) | NS |
P379 Prognostic value of procalcitonin or lactate clearance, or both, for risk assessment in sepsis patients
M Meier1, T Baumgartner1, G Zurauskaité1, S Gupta2, B Mueller1, A Devendra2, P Schuetz1
1Kantonsspital Aarau, Aarau, Switzerland; 2Morton Plant Hospital, Clearwater, FL, United States
P380 Impact of CRP, procalcitonin and CRP on mortality related with sepsis in ICU
D Mandaci, G Eren, F Ozturk, N Emir, O Hergunsel
Bakirkoy Dr.Sadi Konuk Training and Research Hospital, Istanbul, Turkey
P381 Serum procalcitonin in cirrhotic patients: a reliable biomarker of bacterial infection?
S Azaiez, S Khedher, A Maaoui, M Salem
Charles Nicolle Hospital, Tunis, Tunisia
P382 The assessment of bacterial load in ICU nosocomial pneumonia
E Chernevskaya1, N Beloborodova1, A Bedova1, YU Sarshor1, A Pautova1, V Gusarov2
1Negovsky Research Institute of General Reanimatology, Moscow, Russia; 2Pirogov National Medical and Surgical Center, Moscow, Russia
P383 Procalcitonin elimination during cytokine adsorption therapy in septic shock: a spin-off study of the ACESS trial
N Öveges1, I László1, M Forgács1, T Kiss1, P Hankovszky1, P Palágyi1, A Bebes1, B Gubán1, I Földesi1, Á Araczki1, M Telkes1, Z Ondrik1, Z Helyes2, Á Kemény2, Z Molnár1
1University of Szeged, Szeged, Hungary; 2University of Pécs, Pécs, Hungary
P384 qSOFA (quick SOFA) score, presepsin and procalcitonin for severity assessment in initial sepsis
E Spanuth1, H Ebelt2, B Ivandic1, R Thomae3, K Werdan2
1DIAneering GmbH, Heidelberg, Germany; 2Department of Medicine III, University Clinics Halle (Saale), Martin-Luther-University, Halle-Wittemberg, Germany; 3Mitsubishi Chemical Europe, Düsseldorf, Germany
P385 Role of presepsin compared to c-reactive protein in sepsis diagnosis and prognostication
M. El-Shafie1, K Taema1, M El-Hallag1, A Kandeel2
1Cairo University, Cairo, Egypt; 2El-Sahel Teaching Hospital, Cairo, Egypt
P386 Urinary albumin/creatinine ratio as an early predictor of outcome in critically-ill septic patients
O Tayeh1, K Taema1, M Eldesouky1, A Omara2
1Cairo University, Cairo, Egypt; 2Electricity Hospital, Cairo, Egypt
P387 Syndecan-1 (SDC1) and sphingosine-1-phosphate (S1P) are inversely associated in sepsis
MS Winkler1, M Holzmann1, A Nierhaus2, E Mudersbach3, E Schwedhelm3, G Daum4, S Kluge4, C Zoellner1
1Dep. of Anaesthesiology, University Medical Center Eppendorf, Hamburg, Germany; 2Dep. of Intensive Care Medicine, University Medical Center Eppendorf, Hamburg, Germany; 3Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 4Department of Vascular Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
P388 Serum sphingosine-1-phosphate (S1P) levels are rapidly decreasing during coronary artery bypassgraft
G Greiwe1, H Sawari2, E Schwedhelm3, A Nierhaus4, S Kluge4, J Kubitz1, R Jung5, G Daum6, H Reichenspurner2, C Zoellner1, MS Winkler1
1Dep. of Anaesthesiology, University Medical Center Eppendorf, Hamburg, Germany; 2Dep. of Cardiovascular Surgery, University Heart Center Hamburg-Eppendorf, Hamburg, Germany; 3Dep. of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 4Dep. of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 5Dep. of Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 6Dep. of Vascular Medicine, University Heart Center Hamburg-Eppendorf, Hamburg, Germany
P389 Can the biochemical and immunoinflammatory profile of patients sustaining high-energy tibial fractures predict the development of acute posttraumatic osteomyelitis?
M Groznik1, A Ihan2
1University Clinical Centre Ljubljana, Ljubljana, Slovenia; 2University of Ljubljana | Faculty of Medicine, Ljubljana, Slovenia
P390 Coenzyme q10 in acute influenza infection
LW Andersen, M Chase, MJ Holmberg, A Wulff, MN Cocchi, MW Donnino
Beth Israel Deaconess Medical Center, Boston, MA, United States
P391 The research on effects of heparin-binding protein levels on early diagnosis in sepsis, severe sepsis and septic shock
C Balci
Health Sciences University, Kocaeli Derince Traning Hospital, Kocaeli, Turkey
P392 A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS
M Haliloglu, B Bilgili, H Bilgin, U Kasapoglu, I Sayan, M Süzer, L Mulazımoglu, I Cinel
Marmara university hospital, Istanbul, Turkey
P393 An evaluation of the national early warning score in patients with unscheduled admissions to the intensive care unit
V Patel, S Shah, P Parulekar
Royal Sussex County Hospital, Brighton, United Kingdom
Percentage 1 week mortality | Percentage 1 year mortality | |
---|---|---|
NEWS ≤ 6 | 4 | 26 |
NEWS ≥ 7 | 13 | 25 |
P394 National early warning scores (news) in sepsis – how does this score perform against other available markers routinely applied in the emergency department?
C Minton, J Patel, C Ejimofo, H Choi
University Hospital Lewisham, London, United Kingdom
P395 Sepsis-3 definitions predict hospital mortality better than sepsis-2 in oncological patients in a developing country: it’s time to move forward.
R Costa, P Caruso, P Nassar
AC Camargo Cancer Center, Sao Paulo, Brazil
P396 Combining usage of national early warning score (NEWS) and rapid response team (RRT) in post HSCT patients might contribute to prognosis
J Fu1, J Jin1, Y Xu1, J Kong1, D Wu1, A Yaguchi2
1The First Affiliated Hospital of Suzhou University, Suzhou, China; 2Tokyo Women’s Medical University Hospital, Tokyo, Japan
P397 Comparing criteria and scoring systems in ICU sepsis referrals
A Klonis, S Ganguly
New Cross Hospital, Wolverhampton, United Kingdom
P398 Automated microscopy for rapid directed antibiotic treatment of sepsis
M Kollef, C Burnham, B Fuller
Washington University School of Medicine, St Louis, Missouri, United States
P399 Comparison of the sonication method to roll plate method to diagnose central vascular catheter colonization and catheter–related infection in patients of ICU: a randomized prospective study
A Mavrommati, D Chatzilia, E Salla, E Papadaki, S Kamariotis, S Christodoulatos, A Stylianakis, G Alamanos
Alamanos KAT hospital, Kifisia, Greece
P400 Retrospective analysis of microbiological samples at ICU admission
M Simoes, E Trigo, N Silva, P Martins, J Pimentel
Centro Hospitalar Universitario de Coimbra, Coimbra, Portugal
P401 Microbiological yield of bronchoalveolar lavage in the setting of veno-venous ECMO
D Baily1, LA Curran2, E Ahmadnia2, BV Patel2
1Royal Brompton Hospital, London, United Kingdom; 2Royal Brompton and Harefield NHS Trust, London, United Kingdom
P402 Catheterization, bacteriuria and urinary tract infection in coronary care unit
D Adukauskiene1, J Cyziute2, A Adukauskaite3, D Pentiokiniene1
1Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Lithuanian University of Health Sciences, Kaunas, Lithuania; 3Innsbruck Medical University Hospital, Innsbruck, Austria
P403 Bacterial colonization in tracheoventilated patients
F Righetti, E Colombaroli, G Castellano
Intensive Care Unit. St. Boniface Hospital, Verona, Italy
P404 Lower bacterial growth after induction of endotoxin-tolerance in a porcine intensive care sepsis model
F Wilske1, P Skorup1, M Lipcsey2, K Hanslin2, A Larsson1, J Sjölin1
1Uppsala University, Uppsala, Sweden; 2Uppsala University, Department of Surgical Sciences, Uppsala, Sweden
P405 Clinical predictors and outcome of Klebsiella pneumoniae bacteremia in a regional hospital in Hong Kong
M Man1, HP Shum1, YH Chan1, KC Chan2, WW Yan1, RA Lee3, SK Lau4
1Department of ICU, PYNEH, Hong Kong, Chin; 2Department of Anaesthesia and Intensive Care, Tuen Mun Hospital, Hong Kong, China; 3Hong Kong East Cluster Department of Clinical Pathology, Hong Kong, China; 4Department of Microbiology, The University of Hong Kong, Hong Kong, China
P406 Mortality rate of ventilator-associated pneumonia patients receiving tigecycline in intensive care unit, university hospital, Thailand
P Dilokpattanamongkol1, P Thirapakpoomanunt1, R Anakkamaetee1, P Montakantikul1, V Tangsujaritvijit2
1Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
P407 Outbreak of colistin resistant bacteria in a tertiary care center-analysis of risk factors and outcome
S Sinha, J Pati, S Sahu
Apollo hospitals, Bhubaneswar, India
P408 Where are we going? Analysis of MDR and ESBL E. coli monobacteremia in ICU of university hospital
D Adukauskiene, D Valanciene, A Dambrauskiene
Hospital Kaunas Clinics of Lithuanian University of Health Sciences, Kaunas, Lithuania
P409 E. coli bacteremia in intensive care unit: associated factors with length of stay and mortality
D Adukauskiene, D Valanciene, A Dambrauskiene
Hospital Kaunas Clinics of Lithuanian University of Health Sciences, Kaunas, Lithuania
P410 Incidence of ESKAPE pathogens and their antibiotic resistance in patients with invasive devices in the ICU of a public hospital
K Hernandez, T Lopez, D Saca, M Bello
Universidad Dr. Jose Matias Delgado, Santa tecla, El Salvador
P411 Determinants of acinetobacter sepsis in critically ill patients: a comparative study
W Mahmood, K Hamed, N Al Badi, S AlThawadi, S Al Hosaini, N Salahuddin
King Faisal specialist hospital and research centre, Riyadh, Saudi Arabia
P412 Acute respiratory distress syndrome in patients with pneumococcal community-acquired pneumonia
CC Cilloniz1, AC Ceccato1, GL Li Bassi1, MF Ferrer1, AG Gabarrus1, OR Ranzani1, AS San Jose1, CG Garcia Vidal1, JP Puig de la Bella Casa1, FB Blasi2, AT Torres1
1Hospital Clinic, Barcelona, Spain; 2Università degli Studi di Milano, IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
P413 Ventilator-associated pneumonia: MDR Gram-negative bacteria and predictors of mortality
D Adukauskiene1, A Ciginskiene1, A Dambrauskiene2, R Simoliuniene3
1Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania; 2Hospital of Lithuanian University of Health Sciences, Kaunas, Lithuania; 3Lithuanian University of Health Sciences, Kaunas, Lithuania
P414 Predictors of mortality in KPC-Kp bloodstream infection in intensive care units in Italy
G Giuliano1, D Triunfio1, E Sozio1, E Taddei1, E Brogi1, F Sbrana2, A Ripoli2, G Bertolino1, C Tascini3, F Forfori1
1AOUP, Pisa, Italy; 2Fondazione Toscana Gabriele Monasterio, Pisa, Italy; 3First Division of Infectious Diseases, Cotugno Hospital, Napoli, Italy
Survivor (n = 19) | Non survivor (n = 23) | ||
---|---|---|---|
3 Months previous hospitalization | 2/19 (10.5%) | 9/23 (39,1%) | P = 0.054 |
Steroids use | 3/19 (15.8%) | 14/23 (60.9%) | P = 0.024 |
Septic shock | 11/19 (57.9%) | 15/23 (65.2%) | P = 0.045 |
SOFA (day 1) | 8.65 ± 3.37 | 11.9 ± 3.37 | P = 0.015 |
SAPS II (day 1) | 57.58 ± 17.70 | 67.59 ± 20.99 | P = 0.034 |
Charlson Score | 3.05 ± 1.87 | 4.00 ± 1.87 | Ns |
Optimal empirical therapy | 17/19 (89.5%) | 20/23 (87%) | Ns |
Previous carbapenems therapy | 2/19 (10.5%) | 9/23 (39.1%) | P = 0.081 |
Oral gentamicin decontamination | 2/19 (21.1%) | 0/23 (0%) | P = 0.093 |
Gentamicin therapy | 6/14 (42.9%) | 1/23 (4.3%) | P = 0.023 |
Fosfomycin therapy | 5/14 (35.7%) | 3/23 (13%) | P = 0.066 |
Gentamicin associated with other antibiotics | 6/19 (31.6%) | 15/23 (4.3%) | P = 0.072 |
P415 Global burden of neonatal and childhood sepsis
C Fleischmann1, D Goldfarb2, P Schlattmann1, L Schlapbach3, N Kissoon4
1Jena University Hopital, Jena, Germany; 2University of British Columbia, Vancouver, Canada; 3University of Queensland, Brisbane, Australia; 4British Columbia Childrens Hospital, Vancouver, Canada
P416 Epidemiology of sepsis in Turkish intensive care units: a multicenter point- prevalance study.
N Baykara1, H Akalin2, M Kemal Arslantas3, And Sepsis Study Group4
1University of Kocaeli, Kocaeli, Turkey; 2Uludag University, Bursa, Turkey; 3Marmara University, Istanbul, Turkey; 4Turkish Society of Intensive Care Medicine, Istanbul, Turkey
P417 Assessment of clinical criteria for sepsis in low and middle income countries
SG Gavrilovic1, MV Vukoja1, MH Hache2, RK Kashyap3, YD Dong3, OG Gajic3
1Istitute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia; 2CEDIMAT, Santo Domingo, Dominican Republic; 3Mayo Clinic, Rochester, New York, United States
P418 Measuring and comparing sepsis outcomes between countries to explore the impact of heterogeneity: a case study on adult medical admissions in England and Brazil
O Ranzani1, M Shankar-Hari 2, D Harrison1, L Rabello3, K Rowan1, J Salluh3, M Soares3
1Intensive Care National Audit & Research Centre, London, United Kingdom; 2Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; 3DOr Institute for Research and Education - IDOR, Rio De Janeiro, Brazil
P419 Long-term temperature control with the esophageal heat transfer device in non-cardiac-arrest patients
AM Markota, JF Fluher, DK Kogler, ZB Borovšak, AS Sinkovic
University Medical Centre Maribor, Maribor, Slovenia
P420 Effects of adsorption of cytokines early in septic shock (the ‘ACESS-trial’) – results of the pilot study
I László1, N Öveges1, M Forgács1, T Kiss1, P Hankovszky1, P Palágyi1, A Bebes1, B Gubán1, I Földesi1, Á Araczki1, M Telkes1, Z Ondrik1, Z Helyes2, Á Kemény2, Z Molnár1
1University of Szeged, Szeged, Hungary; 2University of Pécs, Pécs, Hungary
P421 Comparative anticoagulant effects of recombinant thrombomodulin, antithrombin, and unfractionated heparin – clinical implications
J Fareed1, Z Siddiqui1, P Aggarwal1, O Iqbal1, D Hoppensteadt1, M Lewis1, R Wasmund1, S Abro1, S Raghuvir1, K Tsuruta2
1Loyola University, Chicago, Illinois, United States; 2Asahi Kasei Pharma America Corporation, Waltham, Massachusetts, United States
P422 Safety of thrombomodulin (ART-123) in surgical patients with sepsis and suspected disseminated intravascular coagulation (S + DIC)
PS Barie1, D Fineberg2, A Radford2, K Tsuruta2
1Weill Cornell Medicine, New York, New York, United States; 2Asahi Kasei Pharma America, Waltham, Massachusetts, United States
ART-123 n = 119 | Placebo n = 107 | Total n = 226 | |
---|---|---|---|
Intra-abdominal | 97(81.5) | 84(78.5) | 181(80.1) |
Thoracic | 6(5.0) | 7(6.5) | 13(5.8) |
GU | 2(1.7) | 5(4.7) | 7(3.1) |
Ortho | 7(4.2) | 5(4.7) | 12(5.3) |
Cardiac | 4(3.3) | 4(3.7) | 8(3.5) |
SSSI | 1(<1) | 2(1.9) | 3(1.3) |
Head /Neck | 1(<1) | 0 | 1(<1) |
UNK | 1(<1) | 0 | 1(<1) |
SP n = 226 | NS n = 515 | |
---|---|---|
Lung | 46(20.4) | 263(51.1) |
Intra-abdominal | 140(61.9) | 65(12.6) |
Urinary | 10(4.4) | 108(21.0) |
Miscellaneous | 30(13.3) | 79(15.3) |
P423 Vasopressin + Norepinephrine in septic shock: effects on renal function – a retrospective analysis
A Casazza1, A Vilardo2, E Bellazzi1, R Boschi1, D Ciprandi1, C Gigliuto1, R Preda1, R Vanzino1, M Vetere1, L Carnevale1
1ASST di Pavia, Vigevano, Italy; 2Scuola di Specialità Anestesia e Rianimazione, Università Degli Studi, Pavia, Italy
P424 Pentaglobin administration provides feature of trained immunity against multidrug-resistant (MDR) gram-negative bacteria
E Kyriazopoulou, A Pistiki, C Routsi, I Tsangaris, E Giamarellos-Bourboulis
National and Kapodistrian University of Athens, Medical School, Athens, Greece
P425 Long-term survival benefit of pentaglobin for severe infections by multidrug-resistant (mdr) gram-negative bacteria
E Kyriazopoulou1, I Tsangaris1, C Routsi1, I Pnevmatikos2, G Vlachogiannis3, E Antoniadou4, K Mandragos5, A Armaganidis1, E Giamarellos-Bourboulis1
1National and Kapodistrian University of Athens, Medical School, Athens, Greece; 2University of Thrace, Alexandroupolis, Greece; 3Aghios Dimitrios General Hospital, Thessaloniki, Greece; 4G.Gennimatas General Hospital, Thessaloniki, Greece; 5Korgialeneion Benakeion Hospital, Athens, Greece
P426 Medical application content quality metrics: a cross-sectional survey of current applications used to aid the management of sepsis
P Allan1, R Oehmen2, J Luo1, C Ellis 1, P Latham3, J Newman 4
1Rockingham General Hospital, Cooloongup, Australia; 2University of Notre Dame, Fremantle, Australia; 3Mackay Hospital, Mackay, Australia; 4Queen Alexandra Hospital, Portsmouth, United Kingdom
P427 Simulating sepsis: can it improve delivery of the sepsis six in the emergency department?
C Pritchett, D Pandya, A Cripps, S Harris, M Jadav, R Langford
Royal Cornwall Hospital, Truro, United Kingdom
P428 Quick sequential organ failure assessment compared to systemic inflammatory response syndrome for predicting sepsis in emergency department
B Ko, H Park
Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, South Korea
P429 Influenza-associated risk factors for ICU admission and mortality
CM Beumer1, R Koch1, D V Beuningen1, AM Oudelashof2, FL Vd Veerdonk1, E Kolwijck1, JG VanderHoeven1, DC Bergmans2, C Hoedemaekers 1
1UMC Nijmegen, Nijmegen, Netherlands; 2Maastricht University Medical Centre, Maastricht, Netherlands
P430 Infection rate during therapeutic hypothermia in children
JB Brandt, J Golej, G Burda, G Mostafa, A Schneider, R Vargha, M Hermon
Medical University of Vienna, Vienna, Austria
P431 The role of the ICU in the spread of Acinetobacter baumannii through the hospital
P Levin1, C Broyer1, M Assous1, Y Wiener-Well1, M Dahan1, S Benenson2, E Ben-Chetrit1
1Shaare Zedek Medical Center, Jerusalem, Israel; 2Hadassah Hospital, Jerusalem, Israel
P432 Observational study of central venous catheter care and reasons for removal
A Faux1, R Sherazi1, A Sethi2, S Saha1
1Queens Hospital, Essex, United Kingdom; 2King George Hospital, Ilford, United Kingdom
No longer indicated | Suspected CR-BSI | Discharged | Routine change | Death | Other | |
---|---|---|---|---|---|---|
N= | 25 | 17 | 17 | 14 | 11 | 3 |
Mean duration (days) | 6.5 | 6.9 | 3.6 | 7.1 | 2.1 | 4.7 |
Cultured | 11 | 17 | 4 | 12 | 0 | 1 |
Colonised | 2 | 6 | 2 | 3 | 0 | 0 |
Positive peripheral culture | 0 | 1 | 0 | 0 | 0 | 0 |
WCC + CRP 48-hours post CVC removal | N= | Mean duration (days) | Colonised | CR-BSI |
---|---|---|---|---|
Increasing trend | 9 | 6.2 | 2 | 0 |
Decreasing trend | 12 | 6.7 | 3 | 1 |
No change | 25 | 6.7 | 8 | 0 |
P433 Elimination of LPS and cytokines from blood of septic patients with LPS-adsorber
M Kiselevskiy1, E Gromova1, S Loginov2, I Tchikileva1, Y Dolzhikova1, N Krotenko 2, R Vlasenko1, N Anisimova1
1Russian Cancer Research Center, Moscow, Russia; 2SP Botkin Hospital, Moscow, Russia
P434 Early appropriate empirical therapy is associated with increased survival rate in patients with abdominal sepsis
S Spadaro, A Fogagnolo, F Remelli, V Alvisi, A Romanello, E Marangoni, C Volta
Sant’Anna Hospital, Ferrara, Italy
P435 Addressing empirical antimicrobial therapy in bacterial pneumonia: a new heterogeneous scoring system
A Degrassi, F Mearelli, C Casarsa, N Fiotti, G Biolo
University of Trieste, Trieste, Italy
P436 Implementation of strategies of antimicrobial stewardship program in an intensive care unit in a university hospital in Chile
M Cariqueo, C Luengo, R Galvez, C Romero, R Cornejo, O Llanos, N Estuardo, P Alarcon
Hospital Clínico Universidad de Chile, Santiago, Chile
P437 Carbapenem resistant enterobacteriaceae (CRE) intraabdominal infections (IAI)
B Magazi 1, S Khan1, J Pasipanodya2
1MSD, Midrand, South Africa; 2BRI, Dallas, Texas, United States
P438 Intraosseous administration of antibiotics during experimental septic shock
M Eriksson1, G Strandberg1, M Lipsey1, A Larsson2
1Surgical Sciences, Uppsala, Sweden; 2Medical Sciences, Uppsala, Sweden
P439 Cycling aminoglycosides in critical care: a change to antimicrobial policy
Z Rajput, F Hiscock, T Karadag, J Uwagwu, S Jain, A Molokhia
Lewisham and Greenwich NHS Trust, London, United Kingdom
ESBL/AMPc | Other gram negatives | |
---|---|---|
Total number of samples | 78 | 4320 |
Gentamicin sensitive-GS/ Amikacin sensitive-AS | 45 | 4266 |
Gentamicin resistant- GR/ AS | 33 | 48 |
GR/ Amikacin resistant-AR | 0 | 6 |
GS/ AR | 0 | 0 |
P440 Continuous infusion of linezolid in critically ill patients: optimizing the dosage regimen through a PK/PD analysis
H Barrasa1, A Soraluce2, E Uson1, A Rodriguez2, A Isla2, A Martin1, B Fernández1, F Fonseca1, JA Sánchez-Izquierdo3, FJ Maynar1
1Hospital Universitario Alava - Santiago, Vitoria, Spain; 2University of the Basque Country UPV/EHU, Vitoria, Spain; 3Hospital Universitario Doce de Octubre, Madrid, Spain
P441 Pharmacokinetics of tigecycline in liver impairment: quantification of liver function with maximal liver function capacity test (LiMAx test)
M Kaffarnik1, R Alraish1, O Frey2, A Roehr2, M Stockmann1, S Wicha3
1Charite Berlin Campus Virchow, Berlin, Germany; 2Pharmacy, Clinic of Heidenheim, Heidenheim, Germany; 3Uppsala University, Dept. of Pharmaceutical Biosciences, Uppsala, Sweden
P442 Susceptibility of ceftolozane/tazobactam against isolates collected from intensive care unit patients in European hospitals (2014-2016)
D Shortridge, M Castanheira, HS Sader, JM Streit, RK Flamm
JMI Laboratories, North Liberty, Iowa, United States
P443 Clinical outcomes of ceftriaxone versus nafcillin or cefazolin for the treatment of methicillin-susceptible staphylococcal aureus bacteremia
K Falsetta, T Lam, S Reidt, J Jancik
Hennepin County Medical Center, Minneapolis, Minnesota, United States
P444 Development of antibiotic treatment algorithms based on gram stain to restrict usage of broad-spectrum antibiotics in the treatment of ventilator-associated pneumonia: a retrospective analysis
T Kinoshita1, J Yoshimura2, K Yamakawa1, S Fujimi1
1Osaka General Medical Center, Osaka, Japan; 2Sakai City Medical Center, Osaka, Japan
P445 Efficacy of murepavadin co-administered with standard-of-care in a phase 2 study in patients with ventilator-associated pneumonia due to Pseudomonas aeruginosa infection
A Armaganidis1, A Torres2, S Zakynthinos3, C Mandragos4, E Giamarellos-Bourboulis5, P Ramirez6, M De la Torre-Prados7, A Rodriguez8, G Dale9, A Wach9, L Beni9, L Hooftman9, C Zwingelstein 9
1National and Kapodestrian University of Athens, Athens, Greece; 2Hospital Clinic, Barcelona, Spain; 3Evangelismos Hospital Medical School of Athens, Athens, Greece; 4Korgialenio-Benakio E.E.S, Athens, Greece; 5University General Hospital “ATTIKON”, Athens, Greece; 6Hospital Universitario Politècnic la Fe, Valencia, Spain; 7Hospital Universitario Virgen de la Victoria, Malaga, Spain; 8Hospital Universitario de Tarragona Joan XXIII, Tarragona, Spain; 9Polyphor Ltd, Allschwil, Switzerland
P446 Cal02: a liposomal anti-toxin therapy in infections – a new adjunctive therapeutic approach for severe community-acquired pneumonia
B François1, G Colin2, PF Dequin3, PF Laterre4, A Perez5
1Medical-Surgical ICU, Inserm CIC-1435, CHU Dupuytren, 87042, Limoges, France; 2Medical-Surgical ICU, District Hospital Center, La Roche-sur-Yon, France; 3Medical-Surgical ICU, University Hospital, Tours, France; 4ICU, Cliniques universitaires Saint-Luc, Université catholique de Louvain (UCL), Brussels, Belgium; 5Combioxin SA, Geneva, Switzerland
P447 Withdrawn
P448 Anidulafungin in ascites and pleural effusion of critically ill patients
R Welte1, I Lorenz1, P Eller2, M Joannidis1, R Bellmann1
1Medical University of Innsbruck, Innsbruck, Austria; 2Medical University of Graz, Graz, Austria
P449 Anidulafungin and the potential cost improvement with Beta-D-Glucan and Candida score associated rationalization of antifungal use
S Lim, S Chana, S Patel
King’s College Hospital, London, United Kingdom
Candida score | BDG tested? | BDG result | Prescribed as per microbiolgy guidelines / advice | Total number | Total days of anidulafungin prescribed |
---|---|---|---|---|---|
<3 (n = 25) | Yes | Positive | Yes | 2 | 12 |
No | 1 | 14 | |||
Negative | Yes | 6 | 58 | ||
No | 2 | 27 | |||
No | N/A | Yes | 9 | 66 | |
No | 5 | 44 | |||
3 or more (n = 13) | Yes | Positive | Yes | 3 | 78 |
No | 0 | 0 | |||
Negative | Yes | 0 | 0 | ||
No | 0 | 0 | |||
No | N/A | Yes | 8 | 62 | |
No | 13 | 13 | |||
Total | 38 | 374 |
P450 Alterations on thyroid function test. predictors of mortality in critically ill patients?
J Higuera, D Cabestrero, L Rey, G Narváez, A Blandino, M. Aroca, S Saéz, R De Pablo
Ramón y Cajal University Hospital, Madrid, Spain
P451 The role of glucagon during critical illness and its modulation by macronutrients
S Thiessen1, I Vanhorebeek1, S Derde1, I Derese1, T Dufour1, C Nadège Albert1, L Langouche1, C Goossens1, N Peersman1, P Vermeersch1, S Vander Perre1, J Holst2, P Wouters1, G Van den Berghe1
1University Hospital, Leuven, Belgium; 2Panum Institute, Copenhagen, Denmark
P452 In vitro administration of ubiquinol and thiamine improve cellular oxygen consumption in patients with diabetic ketoacidosis
X Liu, AU Uber, M Holmberg, V Konanki, M McNaughton, J Zhang, MW Donnino
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
P453 The evaluation of the adherence to and outcome of the blood glucose monitoring protocol
O Demirkiran, A Byelyalov
Istanbul University Cerrahpasa Medical School, Istanbul, Turkey
P454 Insulin receptor b isoforms expression: a new insulin-resistance mechanism in critically ill patients?
C Luengo1, J Guerrero2, M Cariqueo1
1Hospital Clínico Universidad de Chile, Santiago, Chile; 2Universidad de Chile, Santiago, Chile
P455 Association between glycemic variability and nosocomial infection susceptibility in critically ill patients
C Scorcella, R Domizi, E Damiani, S Tondi, S Pierantozzi, N Rossini, U Falanga, V Monaldi, E Adrario, P Pelaia, A Donati
Università Politecnica delle Marche, Ancona, Italy
P456 Glysure versus standard blood glucose monitoring device in patients undergoing cardiac surgery
O Cole1, N Scawn2, M Balciunas1, I Blascovics1, A Vuylsteke1, K Salaunkey1
1Papworth Hospital, Cambridge, United Kingdom; 2Liverpool Heart and Chest Hospital, Liverpool, United Kingdom
P457 Relationship between glycated hemoglobin and poor glucose control in intensive care cardiac surgery settings
A Omar, A Salama, M Allam, A Alkhulaifi
Hamad medical corporation, Doha, Qatar
P458 Leukocyte telomere length in critically ill children: association with outcome and impact of the nutritional management
S Verstraete1, I Vanhorebeek1, E Van Puffelen2, I Derese1, C Ingels1, S Verbruggen2, P Wouters1, K Joosten2, J Hanot1, G Guerra3, D Vlasselaers1, J Lin4, G Van den Berghe1
1KU Leuven, Leuven, Belgium; 2Erasmus Medical Centre, Rotterdam, Netherlands; 3University of Alberta, Edmonton, Canada; 4University of California, San Francisco, San Francisco, United States
P459 Assessment of skeletal muscle wasting in critically ill trauma patients using serial computed tomography imaging
R Haines1, P Zolfaghari1, R Hewson1, C Offiah1, J Prowle2
1Barts Health NHS Trust, London, United Kingdom; 2Queen Mary University, London, United Kingdom
P460 Predictive value of sarcopenia on outcome of sepsis in the emergency department
H Park, B Ko
Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, South Korea
P461 Withdrawn
P462 Comparison between SNAQ and phase angle to assess malnutrition at time of ICU admission
H Buter, JA Veenstra, M Koopmans, EC Boerma
MCL, Leeuwarden, Netherlands
SNAQ 0-1 | SNAQ > =2 | |
---|---|---|
Phase angle normal | 180 | 13 |
Phase angle low | 72 | 34 |
P463 Phase angle is an independent predictor of mortality in ICU patients
JA Veenstra, H Buter, M Koopmans, EC Boerma
MCL, Leeuwarden, Netherlands
PhA normal n = 193 | PhA low n = 106 | P | |
---|---|---|---|
Male n | 137 | 61 | 0.019 |
Age yrs | 63 ± 11 | 71 ± 10 | <0.001 |
BMI | 27 ± 4 | 26 ± 4 | 0.034 |
APACHE II | 13 [10-17] | 15 [12-19 | <0.001 |
LOS ICU days | 0.9 [0.8-1.3] | 0.9 [0.8-3] | 0.234 |
LOS Hosp days | 9 [5-16] | 16 [9-25] | <0.001 |
Mortality ICU % | 3.1 | 9.4 | 0.02 |
Mortality Hosp % | 4.1 | 13.2 | 0.004 |
P464 Assessment of sarcopenia by serial ultrasound measurements of quadreceps femoris cross-sectional area in patient with ischemic cardiomyopathy
A Taha, A Shafie, S Hallaj, D Gharaibeh, H Hon
Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
P465 Prevalence and prognosis impact of malnutrition in elderly of a Moroccan acute medical unit
M Bizrane, A A. El Khattate, N Madani, R Abouqal, J Belayachi
Ibn sina university hospital, Rabat, Morocco
P466 Achievement of 60% targeted cumulative calories in the first week of ARDS reduces 28- day mortality
N Kongpolprom, N Sanguanwong
Chulalongkorn University, Bangkok, Thailand
Group 1 < 60% of 7 day targeted calories n = 68 | Group 2 60-99% of 7 day targeted calories n = 16 | Group 3 ≥ 100% of 7 day targeted calories n = 30 | |
---|---|---|---|
Age mean(SD) years | 54.09(17.85) | 44.50(13.17) | 57.30(21.42) |
Sex male n (%) | 43(63.2) | 5(31.3) | 13(43.3) |
APACHE II median [IQR] | 26.50[9] | 24.00[7.5] | 25.00[8.75] |
PF ratio median [IQR] | 129.40[92.25] | 109.98[69.06] | 107.81[72.41] |
Tidal volume day1 median [IQR] ml/KgIBW | 8.36[3.18] | 8.99[3.04] | 8.05[4.7] |
PEEP day1 median [IQR] cmH2O | 10.00[7] | 10.00[10] | 10.00[6] |
7 day cumulative calories mean(SD) Kcal. | 2545.96(2336.11) | 7171.25(889.28) | 9595.73(1888.90) |
28-day mortality (%) * = p <0.05 compared with gr.1 | 79.4 | 43.8 * | 50 * |
P467 Effect of gastric residual volume monitoring on incidence of ventilator associated pneumonia in mechanically ventilated patients admitted to intensive care unit
S Sanaie, A Mahmoodpoor, H Hamishehkar
Tabriz University of Medical Sciences, Tabriz, Iran
P468 The efficacy of a novel peristaltic feeding tube (PFT) in reducing reflux and aspiration of gastric contents in mechanically-ventilated patients
P Biderman1, P Van Heerden2, Y Avitzur3, S Solomon4, Z Iakobishvili1, U Carmi1, D Gorfil1, P Singer1
1Rabin Medical Center, Petah Tikvah, Israel; 2Hadassah University Hospital, Jerusalem, Israel; 3Hospital for Sick Kids, Toronto, Canada; 4Lunguard Pty Ltd, Yavne, Israel
Site | Treatment group | Control group | p value |
---|---|---|---|
Trachea | 1/26 | 7/36 | 0.22 |
Above the ETT cuff | 24/110 | 46/114 | 0.04 |
Oropharynx | 47/110 | 104/108 | 0.0003 |
P469 Ascertaining correct placement of nasogastric tubes: a single-centre experience
C Paisley1, J Patrick-Heselton1, M Mogk2, J Humphreys3, I Welters1
1Royal Liverpool University Hospital, Liverpool, United Kingdom; 2MoreData GmbH, Giessen, Germany; 3New Marton Farm, Oswestry, United Kingdom
P470 Parenteral nutrition is associated with mortality in critically ill patients
S Pierantozzi, C Scorcella, R Domizi, E Damiani, S Tondi, E Casarotta, S Bolognini, E Adrario, P Pelaia, A Donati
Università Politecnica delle Marche, Ancona, Italy
P471 Thiamine supplementation in septic shock patients with alcohol use disorders
MJ Holmberg, A Moskowitz, P Patel, A Grossestreuer, A Uber, LW Andersen, MW Donnino
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
P472 Is vitamin d deficiency at ER admission associated with an increased mortality from sepsis?
S Malinverni, D Goedeme, P Mols
CHU Saint Pierre, Brussels, Belgium
P473 Vitamin D supplementation in the critically ill: systematic review and meta-analysis
P L Langlois1, C Szwec2, F D’Aragon1, D K Heyland3, W Manzanares4
1Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada; 2Hospital Posadas, Buenos Aires, Argentina; 3Queen’s University, Kingston, Canada; 4Hospital de Clinicas, Montevideo, Uruguay
P474 Current pharmaconutrition practices in the ICU: results of the international nutrition survey 2014-2015
W Manzanares1, C Szwec2, P Langlois3, I Aramendi1, D Heyland4
1University Hospital, Montevideo, Uruguay; 2Hospital Posadas, Buenos Aires, Argentina; 3Université de Sherbrooke, Sherbrooke, Canada; 4Queen’s University, Kingston, Canada
P475 Outcomes in variceal hemorrhage following the use of a balloon tamponade device
N Stankovic, J Nadler, A Uber, M Holmberg, L Sanchez, R Wolfe, M Chase, M Donnino, M Cocchi
Beth Israel Deaconess Medical Center, Boston, United States
P476 Psoas muscle index: an outcome predictor in living donor liver transplantation
HK Atalan1, B Gucyetmez2, ME Kavlak3, S Aslan3, A Kargi3, S Yazici3, R Donmez3, KY Polat3
1Acibadem Fulya Hospital, Istanbul, Turkey; 2Acibadem University School of Medicine, Istanbul, Turkey; 3Atasehir Memorial Hospital, Istanbul, Turkey
P477 An evaluation of the usefulness of extracorporeal liver support techniques in patients hospitalized in the ICU for severe liver dysfunction with no option of transplantation
M Piechota 1, A Piechota2, M Misztal3, S Bernas4, I Pietraszek-Grzywaczewska4
1Dr Wł. Biegański Regional Specialist Hospita, Department of Anaesthesiology and Intensive Therapy – Centre for Artificial Extracorporeal Kidney and Liver Support, Łódź, Poland; 2University of Łódź, Department of Insurance, Łódź, Poland; 3University of Łódź, Chair of Statistical Methods, Łódź, Poland; 4Dr Wł. Biegański Regional Specialist Hospital, Department of Anaesthesiology and Intensive Therapy – Centre for Artificial Extracorporeal Kidney and Liver Support, Łódź, Poland
P478 Degree of hyper-dynamic circulation correlates with the severity of liver disease and predicts poor outcome in spontaneous bacterial peritonitis patients in intensive care unit
M Saleh, A Hamdy, A Hamdy, M Elhallag
Kasr Alainy, Cairo University, Cairo, Egypt
P479 The i.m.p.a.c.t system® device in acute liver failure: clinical experiences in 7 adult patients
F Atar, A Kundakci, E Gedik, H Sahinturk, P Zeyneloglu, A Pirat
Ankara Baskent Hospital, Ankara, Turkey
P480 Effects of platelet count on thromboelastometric parameters in patients with end-stage liver disease
M Popescu, D Tomescu
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
P481 Cholestatic liver injury and disturbed enterohepatic signaling due to diarrhea-induced bile salt malabsorption in critical illness
R Van Gassel1, M Baggerman1, F Schaap2, M Bol1, G Nicolaes2, D Beurskens2, S Olde Damink1, M Van de Poll1
1Maastricht University Medical Centre, Maastricht, Netherlands; 2Maastricht University, Maastricht, Netherlands
P482 Withdrawn
P483 The effectiveness of continuous regional arterial infusion of protease inhibitors in severe acute necrotizing pancreatitis: a retrospective multi-center cohort study
M Horibe1, M Sasaki2, M Sanui3, E Iwasaki1, H Sawano4, T Goto5, T Ikeura6, T Hamada7, T Oda8, T Mayumi9, T Kanai1
1Keio University School of Medicine, Tokyo, Japan; 2National Cancer Center, Tokyo, Japan; 3Jichi Medical University Saitama Medical Center, Saitama, Japan; 4Osaka Saiseikai Senri Hospital, Osaka, Japan; 5Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan; 6Kansai Medical University, Osaka, Japan; 7The University of Tokyo, Tokyo, Japan; 8Iizuka Hospital, Fukuoka, Japan; 9School of Medicine University of Occupational and Environmental Health, Fukuoka, Japan
P484 Detection of complications after pancreas transplantation by microdialysis catheters
G Kjøsen, R Horneland, K Rydenfelt, E Aandahl, T Tønnessen, H Haugaa
Oslo University Hospital, Oslo, Norway
P485 Measurement of LDH in acute pancreatitis - time to let go
P Lockett, L Evans
Norfolk & Norwich University Hospital, Norwich, United Kingdom
P486 Primary anastomosis or defunctioning stoma in emergency laparotomy
L Somerset, F Ker-Reid, S Laver, E Courtney, S Dalton, A Georgiou
Royal United Hospital NHS Foundation Trust, Bath, United Kingdom
P487 Pantoprazole continuous infusion versus intermittent bolus in the treatment of upper gastrointestinal bleeding
K Robinson, T Lam, B Haas, S Reidt, K Bartlett, J Jancik
Hennepin County Medical Center, Minneapolis, Minnesota, United States
P488 Sodium administration in a small UK ITU: audit following a change in practice
M Bigwood
Queen Elizabeth Hospital, Kings Lynn, United Kingdom
Guideline | Source | |
---|---|---|
1 | Use Dex/sal for MIF (unless documented why not) | NICE |
2 | Use fluid with 130–154mmol/l sodium for any resus | NICE |
3 | Receive 0.6-1.4mmol/Kg/day of maintenance sodium | NICE |
4 | Give <2.5L/day Dex/saline | NICE |
5 | Patients with Critical Care induced hypernatraemia | Local |
Guideline | Target | Actual |
---|---|---|
1 | 100% | 100% |
2 | 100% | 100% |
3 | 75% | 83% |
4 | 100% | 97%* |
5 | <5% | 0% |
P489 Dysnatraemia and its impact on mortality on admission to intensive care
R Hanley, P Morgan
East Surrey Hospital, Redhill, United Kingdom
Sodium levels (mmol/L) | Survived | Died | % Mortality |
---|---|---|---|
<114 | 25 | 10 | 28.6 |
115-124 | 119 | 67 | 36.0 |
125-135 | 1723 | 751 | 30.4 |
136-145 | 4861 | 1606 | 24.8 |
146-155 | 387 | 295 | 43.3 |
>156 | 28 | 38 | 57.6 |
P490 Intra-operative chloride load and peri-operative acute kidney injury in high- risk surgical patients
D Marouli, A Chatzimichali, S Kolyvaki, A Panteli, E Diamantaki, E Pediaditis, P Sirogianni, P Ginos, E Kondili, D Georgopoulos, H Askitopoulou
University Hospital, Heraklion, Greece
P491 Is chloride load an important cause of hyperchloremia in critically ill? a retrospective analysis
FG Zampieri1, AB Liborio2, BA Besen3, AB Cavalcanti1
1HCor-Hospital of the Heart, São Paulo, Brazil; 2Universidade de Fortaleza - UNIFOR, Fortaleza, Brazil; 3Hospital das Clínicas - FMUSP, São Paulo, Brazil
P492 Hypercloremia and acid-base changes in critically ill patients requiring fluid resuscitation
C Dominedò, AM Dell’Anna, A Monayer, DL Grieco, R Barelli, SL Cutuli, A Ionescu Maddalena, E Picconi, C Sonnino, C Sandroni, M Antonelli
Catholic University of the Sacred Heart, A. Gemelli University Hospital, Rome, Italy
P493 The relationship between standard base excess and base excess chloride
B Gucyetmez1, HK Atalan2, F Tuzuner3, N Cakar1
1Acibadem University School of Medicine, Istanbul, Turkey; 2Acibadem Fulya Hospital, Istanbul, Turkey; 3Arnavutkoy Hospital, Istanbul, Turkey
P494 A prospective observational study of rational fluid therapy in Asian intensive care units (RaFTA)
M Jacob 1, S Sahu2, YP Singh3, Y Mehta4, KY Yang5, S Kuo6, V Rai6, T Cheng7, C Ertmer8
1Klinikum St. Elisabeth Straubing GmbH, Straubing, Germany; 2Krishna Institue of Medical Science, Secunderabad, Andhra Pradesh, India; 3Max Hospital, Patparganj, New Delhi, India; 4Medanta-The Medicity, Haryana, India; 5Taipei Veterans General Hospital; School of Medicine, National Yang-Ming University, Taipei, Taiwan; 6University of Malaya, Kuala Lumpur, Malaysia; 7Sultanah Aminah Hospital, Bangunan Induk, Jalan Persiaran Abu Bakar Sultan, Johor, Malaysia; 8University Hospital Muenster, Muenster, Germany
P495 Effects of balanced crystalloids and colloids on haemostasis: in vitro assessment
P Czempik
Medical University of Silesia, Katowice, Poland
P496 Microcirculatory hypoperfusion combined with early fluid resuscitation with 0.9% saline predisposes to the development of trauma induced coagulopathy in a porcine model of complex haemorrhagic shock
S Hutchings 1, S Watts2, C Wilson2, C Burton2, E Kirkman2
1Kings College Hospital, London, United Kingdom; 2Defence Science & Technology Laboratory, Salisbury, United Kingdom
P497 Validation of a pharmacokinetic equation for individualised phosphate replacement in critically ill patients: a retrospective observational cohort study
D Drennan, A O’Prey, A MacKay, R Forrest
Queen Elizabeth University Hospital (QEUH), NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
P498 Hydroelectrolitic rebalancing in diabetic ketoacidosis in children
A Oglinda1, G Ciobanu2, M Casian2, C Oglinda2
1Institute of Mother and Child, Chisinau mun., Moldova; 2State University of Medicine and Pharmacy, Chisinau, Moldova
P499 Metformin-associated lactic acidosis requiring intensive care in a regional hospital in Hong Kong and predictive factors for mortality
CT Lun1, HJ Yuen2, G Ng2, A Leung2, SO So1, HS Chan1, KY Lai2
1Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong; 2Queen Elizabeth Hospital, Hong Kong, Hong Kong
Characteristics | Non-survivor n = 5 | Survivor n = 54 | p-value |
---|---|---|---|
APACHE IV score | 145 (30.0) | 108.9 (26.2) | 0.005 |
PaCO2 (kPa) | 4.93 (1.45) | 2.89 (1.34) | 0.002 |
24 hour urine volume (ml) | 45 (17.5-110) | 589.5 (153.8-1427.5 | 0.013 |
Maximum nor-adrenaline(mcg/kg/min) | 2.03 (1.36-2.94) | 0.54 (0.11-1.63) | 0.009 |
Time from admission to RRT (min) | 1180 (515-2070) | 386.5 (136.5-662.5) | 0.043 |
P500 The comparison between intravenous sodium bicarbonate plus NAC and intravenous sodium chloride plus NAC to prevent contrast induced nephropathy in ED
P Sanguanwit1, W Charoensuk2, B Phakdeekitcharoen3
1Faculty of medicine Ramathibodi, Bangkok, Thailand; 2Srisungwan Hospital, Mae Hong Son, Thailand; 3Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Baseline | Sodium Bicarbonate Plus NAC, (N = 42) | Sodium Chloride Plus NAC (N = 41) | P |
---|---|---|---|
Cr (mg/dl) | 1.2(±0.3) | 1.2(±0.3) | 0.67 |
eGFR (ml/min) | 52.1(±15.5) | 51.5 (±14.3) | 0.86 |
Outcome | Sodium Bicarbonate Plus NAC (N = 42) | Sodium Chloride Plus NAC (N = 41) | p |
---|---|---|---|
CIN | 4(9.8%) | 6(15.4%) | 0.51 |
P501 Prophylaxis of contrast-induced nephropathy: haemodynamic effects of hydration with sodium bicarbonate and theophylline
G Batres-Baires, I Kammerzell, T Lahmer, U Mayr, R Schmid, W Huber
Klinikum rechts der Isar; Technical University of Munich, Munich, Germany
P502 Presepsin for early detection of acute kidney injury and mortality prediction in cardiac surgery patients
E Spanuth1, H Bomberg2, M Klingele3, R Thomae4, H Groesdonk2
1DIAneering GmbH, Heidelberg, Germany; 2Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Saarland University, University Medical Centre, Homburg/Saar, Germany; 3Department of Medicine, Division of Nephrology and Hypertension, Saarland University, University Medical Centre, Homburg/Saar, Germany; 4Mitsubishi Chemical Europe, Düsseldorf, Germany
AKIN = 0 (n = 635), median (IQR) | AKIN = 1,2,3 (n = 222), median (IQR) | RO-AUC | |
---|---|---|---|
EuroScore II | 3.15 (1.63-6.13) | 6.23 (3.5-12.8) | 0.701 |
PCT, ng/L | 0.65 (0.30-1.59) | 1.56 (0.60-5.34) | 0.674 |
PSEP, ng/L | 306 (228-436) | 632 (378-1077) | 0.782 |
P503 Life-threatening exertional rhabdomyolysis in a 35-year-old ultramarathon runner – case report
S Bernas, M Piechota, K Mirkiewicz
Dr Wł. Biegański Regional Specialist Hospital, Department of Anaesthesiology and Intensive Therapy – Centre for Artificial Extracorporeal Kidney and Liver Support, Łódź, Poland
P504 Impact on the development of acute renal injury of two doses of glucocorticoids during cardiopulmonary bypass in cardiac surgery
A González Pérez, J Silva
Hospital Universitario Central de Asturias, Oviedo, Spain
P505 Factors that predict supranormal glomerular filtration in critical diseases
A Ramos1, F Acharta1, M Perezlindo1, L Lovesio1, P Gauna Antonelli1, A Dogliotti2, C Lovesio1
1Sanatorio Parque, Rosario, Argentina; 2Grupo Oroño, Rosario, Argentina
P506 Macrophage migration inhibitory factor versus neutrophil gelatinase-associated lipocalin-2 to predict acute kidney injury after liver transplantation
J Baron, J Schiefer, DM Baron, P Faybik
Medical University Vienna, Vienna, Austria
P507 Factors associated with lack of full renal recovery after 90 days in critically ill patients with AKI
HP Shum1, WW Yan1, TM Chan2
1Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong; 2The University of Hong Kong, Hong Kong, Hong Kong
P508 Early predictive markers of peri-operative acute kidney injury in non-cardiac major surgery
D Marouli, A Chatzimichali, S Kolyvaki, A Panteli, E Diamantaki, E Pediaditis, P Sirogianni, P Ginos, E Kondili, D Georgopoulos, H Askitopoulou
University Hospital, Heraklion, Greece
P509 Bioelectrical impedance analysis measurements as predictors of impaired renal function after cardiac surgery
V Vicka, D Gineityte, D Ringaitiene, J Sipylaite, J Pekarskiene
Vilnius University, Vilnius, Lithuania
P510 Extracellular histones in machine perfusate of donation after circulatory death kidneys correlate with graft function after transplantation
DM Beurskens1, TC Van Smaalen2, P Hoogland2, B Winkens3, MH Christiaans2, CP Reutelingsperger1, E Van Heurn4, GA Nicolaes1
1Cardiovascular Research Institute Maastricht (CARIM), Maastricht, Netherlands; 2Maastricht University Medical Center (MUMC), Maastricht, Netherlands; 3School for Public Health and Primary Care (CAPHRI), Maastricht, Netherlands; 4Academic Medical Center Amsterdam, Amsterdam, Netherlands
P511 Biomarkers of cell cycle arrest and cell death as early predictors for delayed graft function in patients following kidney transplantation – results of an observational clinical study
FS Schmitt, ES Salgado, JF Friebe, TF Fleming, JZ Zemva, TS Schmoch, FU Uhle, LK Kihm, CM Morath, CN Nusshag, MZ Zeier, TB Bruckner, AM Mehrabi, PN Nawroth, MW Weigand, SH Hofer, TB Brenner
University Hospital Heidelberg, Heidelberg, Germany
P512 Effectiveness of renal resistive index (RRI) in predicting acute kidney injury of early onset in critically ill patients
G Fotopoulou1, I Poularas2, S Kokkoris1, E Brountzos1, S Zakynthinos1, C Routsi1
1National and Kapodistrian University of Athens, Athens, Greece; 2General Hospital of Athens, Athens, Greece
P513 Association of acute kidney injury defined by AKIN criteria with poor outcome in acute respiratory distress syndrome patients
M Saleh, M Elghonemi
Kasr Alainy, Cairo University, Cairo, Egypt
P514 The novel nitric-oxide donor pdno attenuates ischemia-reperfusion induced renal dysfunction
KF Nilsson1, J Sandin2, L Gustafsson2, R Frithiof3
1Örebro University Hospital, Örebro, Sweden; 2Karolinska Institutet, Stockholm, Sweden; 3Uppsala University, Uppsala, Sweden
P515 Association between fluid accumulation at initiation of acute renal replacement therapy and mortality in critically ill patients with acute kidney injury
I Skorniakov1, A Varaksin2, D Vikulova3, O Shaikh1, C Whiteley1, M Ostermann1
1Guy’s & St Thomas’ NHS Foundation Trust, London, United Kingdom; 2Institute of Industrial Ecology, Russian Academy of Sciences, Ekaterinburg, Russia; 3Sverdlovsk Regional Clinical Hospital 1, Ekaterinburg, Russia
Parameters | CFB ≤10% BW | CFB >10% BW | p |
---|---|---|---|
Age in years, mean | 62.8 | 63.8 | 0.55 |
SOFA score on 1st day of RRT, mean | 10.1 | 11.5 | 0.0002 |
Days in ICU, mean | 13.8 | 21.3 | 0.0001 |
Hospital mortality | 0.42 | 0.54 | 0.025 |
P516 Central venous catheter (cvc) as temporary vascular access in haemodialysis: indications, complications and follow-up
G Di Lascio, L Anicetti, M Bonizzoli, G Fulceri, ML Migliaccio, P Sentina, M Cozzolino, A Peris
Careggi Teaching Hospital, Florence, Italy
Removal for: | Short-term Jugular CVC | Short-term Femoral CVC | Short term CVC tot | Long-term CVC | p |
---|---|---|---|---|---|
All complications (n) | 5 | 36 | 41 | 5 | <.001 |
CRB (n) | 4 | 12 | 16 | 4 | <.005 |
Dysfunction(n) | 2 | 25 | 27 | 2 | <.005 |