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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 12/2022

03.08.2022 | Editorial

[64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation

verfasst von: Fang Xie, Weijun Wei

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 12/2022

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Excerpt

In the current issue of the European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI), Yoo et al. [1] reported that [64Cu][Cu(ATSM-FITC)] positron emission tomography (PET) could accurately detect hydrogen sulfide (H2S) in brain pathophysiology, opening a new horizon for detecting neuroinflammation by mapping H2S level. In the below paragraphs, we first would like to introduce several targets and associated tracers used for detecting neuroinflammation and then the theranostic potential of [64Cu]Cu-ATSM in preclinical and clinical settings. At the end of the manuscript, we will highlight the findings and potential applications of [64Cu][Cu(ATSM-FITC)] reported by Yoo et al. By introducing the background and the most recent proceedings, readers may get a balanced understanding of the relevant information. …
Literatur
21.
Zurück zum Zitat Van Weehaeghe D, Koole M, Schmidt ME, Deman S, Jacobs AH, Souche E, et al. [(11)C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers. Eur J Nucl Med Mol Imaging. 2019;46:2051–64. https://doi.org/10.1007/s00259-019-04369-6.CrossRefPubMed Van Weehaeghe D, Koole M, Schmidt ME, Deman S, Jacobs AH, Souche E, et al. [(11)C]JNJ54173717, a novel P2X7 receptor radioligand as marker for neuroinflammation: human biodistribution, dosimetry, brain kinetic modelling and quantification of brain P2X7 receptors in patients with Parkinson’s disease and healthy volunteers. Eur J Nucl Med Mol Imaging. 2019;46:2051–64. https://​doi.​org/​10.​1007/​s00259-019-04369-6.CrossRefPubMed
26.
Zurück zum Zitat Zhou X, Ji B, Seki C, Nagai Y, Minamimoto T, Fujinaga M, et al. PET imaging of colony-stimulating factor 1 receptor: a head-to-head comparison of a novel radioligand, (11)C-GW2580, and (11)C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. J Cereb Blood Flow Metab : Off J Int Soc Cereb Blood Flow Metab. 2021;41:2410–22. https://doi.org/10.1177/0271678X211004146.CrossRef Zhou X, Ji B, Seki C, Nagai Y, Minamimoto T, Fujinaga M, et al. PET imaging of colony-stimulating factor 1 receptor: a head-to-head comparison of a novel radioligand, (11)C-GW2580, and (11)C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey. J Cereb Blood Flow Metab : Off J Int Soc Cereb Blood Flow Metab. 2021;41:2410–22. https://​doi.​org/​10.​1177/​0271678X21100414​6.CrossRef
30.
Zurück zum Zitat Villemagne VL, Harada R, Dore V, Furumoto S, Mulligan R, Kudo Y, et al. First-in-human evaluation of (18)F-SMBT-1, a novel (18)F-labeled MAO-B PET tracer for imaging reactive astrogliosis. Journal of nuclear medicine: official publication. J Nucl Med. 2022;jnumed.121.263254. https://doi.org/10.2967/jnumed.121.263254 Villemagne VL, Harada R, Dore V, Furumoto S, Mulligan R, Kudo Y, et al. First-in-human evaluation of (18)F-SMBT-1, a novel (18)F-labeled MAO-B PET tracer for imaging reactive astrogliosis. Journal of nuclear medicine: official publication. J Nucl Med. 2022;jnumed.121.263254. https://​doi.​org/​10.​2967/​jnumed.​121.​263254
42.
45.
Zurück zum Zitat Lewis JS, McCarthy DW, McCarthy TJ, Fujibayashi Y, Welch MJ. Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model. J Nucl Med. 1999;40:177–83.PubMed Lewis JS, McCarthy DW, McCarthy TJ, Fujibayashi Y, Welch MJ. Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model. J Nucl Med. 1999;40:177–83.PubMed
48.
Zurück zum Zitat Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med. 1997;38:1155–60.PubMed Fujibayashi Y, Taniuchi H, Yonekura Y, Ohtani H, Konishi J, Yokoyama A. Copper-62-ATSM: a new hypoxia imaging agent with high membrane permeability and low redox potential. J Nucl Med. 1997;38:1155–60.PubMed
50.
Zurück zum Zitat Lewis JS, Sharp TL, Laforest R, Fujibayashi Y, Welch MJ. Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation. J Nucl Med. 2001;42:655–61.PubMed Lewis JS, Sharp TL, Laforest R, Fujibayashi Y, Welch MJ. Tumor uptake of copper-diacetyl-bis(N(4)-methylthiosemicarbazone): effect of changes in tissue oxygenation. J Nucl Med. 2001;42:655–61.PubMed
51.
Zurück zum Zitat O’Donoghue JA, Zanzonico P, Pugachev A, Wen B, Smith-Jones P, Cai S, et al. Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models. Int J Radiat Oncol Biol Phys. 2005;61:1493–502. https://doi.org/10.1016/j.ijrobp.2004.12.057.CrossRefPubMed O’Donoghue JA, Zanzonico P, Pugachev A, Wen B, Smith-Jones P, Cai S, et al. Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent microscopy in the R3327-AT and FaDu rat tumor models. Int J Radiat Oncol Biol Phys. 2005;61:1493–502. https://​doi.​org/​10.​1016/​j.​ijrobp.​2004.​12.​057.CrossRefPubMed
78.
Zurück zum Zitat Pyun J, McInnes LE, Donnelly PS, Mawal C, Bush AI, Short JL, et al. Copper bis(thiosemicarbazone) complexes modulate P-glycoprotein expression and function in human brain microvascular endothelial cells. J Neurochem. 2022;(3):226-244. https://doi.org/10.1111/jnc.15609 Pyun J, McInnes LE, Donnelly PS, Mawal C, Bush AI, Short JL, et al. Copper bis(thiosemicarbazone) complexes modulate P-glycoprotein expression and function in human brain microvascular endothelial cells. J Neurochem. 2022;(3):226-244. https://​doi.​org/​10.​1111/​jnc.​15609
80.
Zurück zum Zitat Cheng XT, Huang N, Sheng ZH. Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Neuron. 2022;110(12):1899–1923. Cheng XT, Huang N, Sheng ZH. Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration. Neuron. 2022;110(12):1899–1923.
81.
Zurück zum Zitat Eldeeb MA, Thomas RA, Ragheb MA, Fallahi A, Fon EA. Mitochondrial quality control in health and in Parkinson's disease. Physiol Rev. 2022;102(4):1721–1755. Eldeeb MA, Thomas RA, Ragheb MA, Fallahi A, Fon EA. Mitochondrial quality control in health and in Parkinson's disease. Physiol Rev. 2022;102(4):1721–1755.
84.
Zurück zum Zitat Lewis JS, Herrero P, Sharp TL, Engelbach JA, Fujibayashi Y, Laforest R, et al. Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone). J Nucl Med. 2002;43:1557–69.PubMed Lewis JS, Herrero P, Sharp TL, Engelbach JA, Fujibayashi Y, Laforest R, et al. Delineation of hypoxia in canine myocardium using PET and copper(II)-diacetyl-bis(N(4)-methylthiosemicarbazone). J Nucl Med. 2002;43:1557–69.PubMed
Metadaten
Titel
[64Cu]Cu-ATSM: an emerging theranostic agent for cancer and neuroinflammation
verfasst von
Fang Xie
Weijun Wei
Publikationsdatum
03.08.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 12/2022
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-022-05887-6

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