Skip to main content
main-content
Erschienen in: Endocrine 2/2020

21.05.2020 | Editorial

A bridge too far? Attempting to bridge the treatment gap in osteoporosis

verfasst von: Bart L. Clarke, Dolores M. Shoback

Erschienen in: Endocrine | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Excerpt

Despite substantial progress in the diagnosis and treatment of osteoporosis over the 25 years since the approval of the first bisphosphonate alendronate in 1995, osteoporosis remains significantly underrecognized and undertreated [ 1]. Osteoporosis causes low-trauma fractures that result in substantial morbidity, mortality, health care expense, and other societal costs. These consequences from fractures have persisted, despite major advances in the ability to predict future fractures based on bone mineral density (BMD) testing and a wide range of cost-effective therapeutic options approved by the FDA, EMA, and other regulatory agencies around the world [ 2]. Bisphosphonates were first developed beginning about 50 years ago, BMD by dual-energy x-ray absorptiometry (DXA) about 35 years ago, the first anabolic agent 18 years ago, and country-specific FRAX algorithms to predict fractures in patients with osteopenia beginning 11 years ago. …
Literatur
1.
Zurück zum Zitat R. Eastell, C.J. Rosen, D.M. Black, A.M. Cheung, H.M. Murad, D.M. Shoback, Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 104, 1595–1622 (2019) CrossRef R. Eastell, C.J. Rosen, D.M. Black, A.M. Cheung, H.M. Murad, D.M. Shoback, Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 104, 1595–1622 (2019) CrossRef
2.
Zurück zum Zitat J.E. Compston, M.R. McClung, W.D. Leslie, Osteoporosis. Lancet 393, 364–376 (2019) CrossRef J.E. Compston, M.R. McClung, W.D. Leslie, Osteoporosis. Lancet 393, 364–376 (2019) CrossRef
4.
Zurück zum Zitat D.H. Solomon, S.S. Johnston, N.N. Boytsov, D. McMorrow, J.M. Lane, K.D. Krohn, Osteoporosis medication use after hip fracture in U.S. patients between 2002 and 2011. J. Bone Miner. Res. 29, 1929–1937 (2014) CrossRef D.H. Solomon, S.S. Johnston, N.N. Boytsov, D. McMorrow, J.M. Lane, K.D. Krohn, Osteoporosis medication use after hip fracture in U.S. patients between 2002 and 2011. J. Bone Miner. Res. 29, 1929–1937 (2014) CrossRef
5.
Zurück zum Zitat S. Khosla, J.A. Cauley, J. Compston et al. Addressing the crisis in the treatment of osteoporosis: a path forward. J. Bone Miner. Res. 32, 424–430 (2017) CrossRef S. Khosla, J.A. Cauley, J. Compston et al. Addressing the crisis in the treatment of osteoporosis: a path forward. J. Bone Miner. Res. 32, 424–430 (2017) CrossRef
6.
Zurück zum Zitat R.J. Desai, M. Maheshri, Y. Abdia et al. Association of osteoporosis medication use after hip fracture with prevention of subsequent nonvertebral fractures: an instrumental variable analysis. JAMA N. Open 1, e180826 (2018) CrossRef R.J. Desai, M. Maheshri, Y. Abdia et al. Association of osteoporosis medication use after hip fracture with prevention of subsequent nonvertebral fractures: an instrumental variable analysis. JAMA N. Open 1, e180826 (2018) CrossRef
7.
Zurück zum Zitat S. Hawley, J. Leal, A. Delmestri et al. Anti-osteoporosis medication prescriptions and incidence of subsequent fracture among primary hip fracture patients in England and Wales: an interrupted time-series analysis. J. Bone Miner. Res. 31, 2008–2015 (2016) CrossRef S. Hawley, J. Leal, A. Delmestri et al. Anti-osteoporosis medication prescriptions and incidence of subsequent fracture among primary hip fracture patients in England and Wales: an interrupted time-series analysis. J. Bone Miner. Res. 31, 2008–2015 (2016) CrossRef
8.
Zurück zum Zitat C.H. Wu, S.T. Tu, Y.F. Chang et al. Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: a systematic literature review and meta-analysis. Bone 111, 92–100 (2018) CrossRef C.H. Wu, S.T. Tu, Y.F. Chang et al. Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: a systematic literature review and meta-analysis. Bone 111, 92–100 (2018) CrossRef
10.
Zurück zum Zitat R.B. Conley, G. Adib, R.A. Adler et al. Secondary fracture prevention: consensus clinical recommendations from a multistakeholder coalition. J. Bone Miner. Res. 35, 36–52 (2020) CrossRef R.B. Conley, G. Adib, R.A. Adler et al. Secondary fracture prevention: consensus clinical recommendations from a multistakeholder coalition. J. Bone Miner. Res. 35, 36–52 (2020) CrossRef
Metadaten
Titel
A bridge too far? Attempting to bridge the treatment gap in osteoporosis
verfasst von
Bart L. Clarke
Dolores M. Shoback
Publikationsdatum
21.05.2020
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 2/2020
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-020-02346-w

Weitere Artikel der Ausgabe 2/2020

Endocrine 2/2020 Zur Ausgabe

Neu im Fachgebiet Innere Medizin

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Innere Medizin und bleiben Sie gut informiert – ganz bequem per eMail.