Erschienen in:
29.06.2020 | Letter to the Editor
A case for Tamoxifen with ovarian function suppression
verfasst von:
Pallavi Kopparthy, Karen Daily
Erschienen in:
Breast Cancer Research and Treatment
|
Ausgabe 1/2020
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Excerpt
Adjuvant endocrine treatment for premenopausal hormone receptor-positive breast cancer has become increasingly nuanced. Sufficient evidence and thus consensus exists on the treatment of patients at both ends of the spectrum; the lowest risk have excellent outcomes with Tamoxifen (TAM) alone for 5 years, and the highest risk have incremental benefit with the escalation of care to GnRHa-based ovarian function suppression (OFS) concurrent with chemotherapy followed by an Aromatase Inhibitor (AI). We describe clinical scenarios in which the third option, TAM with OFS, remains our preferred approach. …