The online version of this article (doi:10.1186/1477-7819-10-74) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
PKK collected the information, researched the literature, and wrote the article, YSI and SKW helped with literature research and in preparing the manuscript, KYY performed the histological examination and helped prepare the manuscript, YKY helped in literature research and edited the final version of manuscript. All authors read and approved the final manuscript.
Metastatic leptomeningeal carcinomatosis is estimated to occur in 3% to 8% of solid carcinomas. The most common causes of leptomeningeal carcinomatosis are breast cancer, lung cancer and malignant melanoma. Leptomeningeal carcinomatosis associated with gastric cancer, especially in its early stages, is exceedingly rare. Its presenting symptoms include headache, nauseaand seizures. In this report, we describe a case of leptomeningeal metastasis that presented with early-stage gastric cancer. A 67-year-old woman with a history of early-stage gastric cancer in remission was admitted to our hospital with 3 days of headache and nausea. Her gastric cancer had been treated 29 months prior to presentation by a radical subtotal gastrectomy with a Billroth I anastomosis. She had an uneventful recovery until she was diagnosed with metastases to the left axilla and neck 26 months after surgery. Her presenting symptoms of headache and nausea prompted cytologic examination of the cerebrospinal fluid and measurement of tumor markers, which revealed metastatic leptomeningeal carcinomatosis from her gastric cancer. This report aims to raise awareness of the possibility that even early-stage gastric cancer can lead to leptomeningeal carcinomatosis.
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- A case of metastatic leptomeningeal carcinomatosis from early gastric carcinoma
- BioMed Central
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