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01.12.2018 | Case report | Ausgabe 1/2018 Open Access

BMC Medical Genetics 1/2018

A case of molecularly profiled extraneural medulloblastoma metastases in a child

Zeitschrift:
BMC Medical Genetics > Ausgabe 1/2018
Autoren:
Nahla Ali Mobark, Musa Al-Harbi, Othman Mosleh, Sandro Santagata, Matija Snuderl, Malak Abedalthagafi

Abstract

Background

Extraneural metastases are relatively rare manifestations of medulloblastoma.

Case presentation

We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options.

Conclusion

To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.
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