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01.12.2018 | Case report | Ausgabe 1/2018 Open Access

BMC Medical Genetics 1/2018

A case of molecularly profiled extraneural medulloblastoma metastases in a child

BMC Medical Genetics > Ausgabe 1/2018
Nahla Ali Mobark, Musa Al-Harbi, Othman Mosleh, Sandro Santagata, Matija Snuderl, Malak Abedalthagafi



Extraneural metastases are relatively rare manifestations of medulloblastoma.

Case presentation

We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options.


To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.
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