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Erschienen in: Clinical and Experimental Nephrology 6/2008

01.12.2008 | Case Report

A case report of glomerulopathy-associated podocytic infolding in a patient with tumor lysis syndrome

verfasst von: Kazunobu Yoshimura, Kensuke Joh, Hiroshi Kitamura, Yasuhito Takahashi, Shinya Yokote, Kenji Kasai, Tatsuo Hosoya

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 6/2008

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Abstract

A 59-year-old man underwent total gastrectomy and splenectomy for gastric cancer 14 months before admission. The pathological diagnosis was neuroendocrine carcinoma of the stomach. Eight months after the operation, systemic chemotherapy with irinotecan and cisplatin was started because of multiple metastases to lymph nodes. After two courses of chemotherapy, renal function continued to decline. Renal biopsy showed acute tubular necrosis with cast formation, where needle crystallization was found. These clinicopathological findings suggested that tumor lysis syndrome was the cause of acute renal insufficiency. Moreover, diffuse, global bubbling and focal segmental spike formation were revealed by periodic acid-silver methenamine stain in the glomerular basement membrane. Electron microscopy showed an infolding of the cytoplasm of podocytes into the basal basement membrane and spotty electron-lucent areas. These ultrastructural findings, but not epimembranous deposits, corresponded with the bubbling on PAM staining. The present case was a rare case of glomerulopathy associated with podocytic infolding, which was not associated with collagen disease but with tumor lysis syndrome.
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Metadaten
Titel
A case report of glomerulopathy-associated podocytic infolding in a patient with tumor lysis syndrome
verfasst von
Kazunobu Yoshimura
Kensuke Joh
Hiroshi Kitamura
Yasuhito Takahashi
Shinya Yokote
Kenji Kasai
Tatsuo Hosoya
Publikationsdatum
01.12.2008
Verlag
Springer Japan
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 6/2008
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-008-0099-5

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