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01.12.2015 | Case report | Ausgabe 1/2015 Open Access

BMC Surgery 1/2015

A case report of primary neuroendocrine carcinoma of the perihilar bile duct

Zeitschrift:
BMC Surgery > Ausgabe 1/2015
Autoren:
Yasuhiro Kihara, Hiroshi Yokomizo, Takahiro Urata, Michiko Nagamine, Toshihiko Hirata
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YK performed the surgery, wrote the case report, made literature review and drafted the manuscript. HY is the senior surgeon who performed all operations assisted by the authors, and revised the manuscript. TU is the gastroenterologist and performed preoperative examination. MN is the pathologist, performed conventional and immunohistochemical staining of NEC of extrahepatic biliary tract, and revised the manuscript. TH is the chief of our division of general surgery, and revised the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Although neuroendocrine tumors are most commonly found in the digestive system, neuroendocrine tumors originating from the bile duct are rare, and neuroendocrine carcinomas derived from the perihilar bile duct are extremely rare. This report presents the clinical course and clinicopathological features of neuroendocrine carcinomas arising from the extrahepatic bile duct.

Case presentation

A 70-year-old Japanese woman was preoperatively diagnosed with perihilar cholangiocarcinoma, and a radical resection with an extended left hepatic lobectomy and a choledochojejunostomy was performed. From the histopathological findings, we diagnosed the tumor as a neuroendocrine carcinoma of the bile duct (small cell type) with lymph node metastasis. The patient was treated with the same adjuvant chemotherapy as that used for small cell carcinoma of the lung. At 10 months after surgery, there was no recurrence of the disease.

Conclusion

Neuroendocrine carcinoma of the extrahepatic biliary tracts is a very rare and highly malignant disease with a poor prognosis. A multidisciplinary approach could improve the prognosis for this neoplasm.
Literatur
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