Erschienen in:
11.07.2017 | Original Article
A cinnamon-derived procyanidin type A compound inhibits hepatitis C virus cell entry
verfasst von:
Catherine Fauvelle, Melanie Lambotin, Laura Heydmann, Ekambaranellore Prakash, Sunil Bhaskaran, Mohan Vishwaraman, Thomas F. Baumert, Christiane Moog
Erschienen in:
Hepatology International
|
Ausgabe 5/2017
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Abstract
Background and aims
Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Although direct-acting antivirals can cure the large majority of treated patients, important limitations remain, including treatment failure and high costs precluding access to therapy in resource-limited settings. We report herein the anti-HCV effects of IND02, a procyanidin type A molecule, isolated and characterized from cinnamon.
Methods and results
Using cellculture-derived HCV (HCVcc), HCV pseudoparticles (HCVpp), and subgenomic replicons, we demonstrated that IND02 markedly and dose-dependently inhibited HCV cell entry. Kinetic assays demonstrated that IND02 inhibits HCV entry most likely at a postbinding step. Experiments performed using primary human hepatocytes confirmed inhibition of HCV entry by IND02, demonstrating the functional impact in the most physiological cell-based system for studying HCV–host interactions.
Conclusions
The natural compound IND02 exhibits potent HCV cell entry inhibition and provides a novel perspective for development of a low-cost antiviral for treatment of HCV infection.