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Erschienen in: Hepatology International 5/2017

11.07.2017 | Original Article

A cinnamon-derived procyanidin type A compound inhibits hepatitis C virus cell entry

verfasst von: Catherine Fauvelle, Melanie Lambotin, Laura Heydmann, Ekambaranellore Prakash, Sunil Bhaskaran, Mohan Vishwaraman, Thomas F. Baumert, Christiane Moog

Erschienen in: Hepatology International | Ausgabe 5/2017

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Abstract

Background and aims

Chronic hepatitis C virus (HCV) infection is a major cause of liver disease worldwide. Although direct-acting antivirals can cure the large majority of treated patients, important limitations remain, including treatment failure and high costs precluding access to therapy in resource-limited settings. We report herein the anti-HCV effects of IND02, a procyanidin type A molecule, isolated and characterized from cinnamon.

Methods and results

Using cellculture-derived HCV (HCVcc), HCV pseudoparticles (HCVpp), and subgenomic replicons, we demonstrated that IND02 markedly and dose-dependently inhibited HCV cell entry. Kinetic assays demonstrated that IND02 inhibits HCV entry most likely at a postbinding step. Experiments performed using primary human hepatocytes confirmed inhibition of HCV entry by IND02, demonstrating the functional impact in the most physiological cell-based system for studying HCV–host interactions.

Conclusions

The natural compound IND02 exhibits potent HCV cell entry inhibition and provides a novel perspective for development of a low-cost antiviral for treatment of HCV infection.
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Metadaten
Titel
A cinnamon-derived procyanidin type A compound inhibits hepatitis C virus cell entry
verfasst von
Catherine Fauvelle
Melanie Lambotin
Laura Heydmann
Ekambaranellore Prakash
Sunil Bhaskaran
Mohan Vishwaraman
Thomas F. Baumert
Christiane Moog
Publikationsdatum
11.07.2017
Verlag
Springer India
Erschienen in
Hepatology International / Ausgabe 5/2017
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-017-9809-y

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