Skip to main content
Erschienen in: Comparative Clinical Pathology 6/2018

04.07.2018 | Original Article

A comparative study of hepatoprotective effect of Inula britannica L aqueous extract and glibenclamide in streptozotocin-induced diabetic mice

verfasst von: Mohammad Mahdi Zangeneh, Akram Zangeneh, Maryam Almasi, Reza Tahvilian, Fariba Hosseini, Rohallah Moradi

Erschienen in: Comparative Clinical Pathology | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

Inula britannica L. has been used in medicine as a theraputical agent. The aim of the present study was to assess the hepatoprotective property of I. britannica aqueous extract against streptozotocin (STZ)-induced diabetes in mice. In this study, 60 mice were used. Diabetes was experimentally induced by injection of STZ in 50 mice. The levels of blood glucose were evaluated by glucometer strips. Mice with plasma glucose level more than 250 mg/dL were considered diabetic. After 3 days, they were divided randomly into six groups. Groups 1 and 2 served as non-diabetic and untreated diabetic controls, respectively. Group 3 received 30 mg/kg glibenclamide orally. Groups 4, 5, and 6 were given 30, 90, and 270 mg/kg, respectively, of I. britannica for 20 days orally. At 20th day, the mice were dissected; blood and liver samples collected for hematological, biochemical, and histological parameter analysis. Hematologically, I. britannica and glibenclamide could reduce significantly (p ≤ 0.05) the raised levels of WBC, platelet, and increased RBC number as compared to the untreated group. Biochemically, I. britannica at all dose (especially IB270) and glibenclamide could significantly (p ≤ 0.05) reduce the raised levels of glucose, ALP, AST, ALT, cholesterol, LDL, and increased HDL, SOD, and CAT levels as compared to the untreated group. Histologically, different doses of I. britannica (especially IB270) similar to glibenclamide could significantly (p ≤ 0.05) decreased the volume of the liver structures as compared to the untreated group. It concluded that I. britannica could ameliorate hyperglycemia and improved hepatic changes following diabetes in STZ-induced diabetic mice. So, according to these features, it could be used as an antidiabetic supplement or drug.
Literatur
Zurück zum Zitat Abei H (1974) Catalase. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 673–684CrossRef Abei H (1974) Catalase. In: Bergmeyer HU (ed) Methods of enzymatic analysis. Academic Press, New York, pp 673–684CrossRef
Zurück zum Zitat Ahmed D, Kumar V, Verma A, Gupta PS, Kumar H, Dhingra V, Mishra V, Sharma M (2014) Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/ dichloromethane extract of Albizzia Lebbeck Benth. Stem bark (ALEx) on streptozotocin induced diabetic rats. Complement Altern Med 14:243–260CrossRef Ahmed D, Kumar V, Verma A, Gupta PS, Kumar H, Dhingra V, Mishra V, Sharma M (2014) Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/ dichloromethane extract of Albizzia Lebbeck Benth. Stem bark (ALEx) on streptozotocin induced diabetic rats. Complement Altern Med 14:243–260CrossRef
Zurück zum Zitat Bai N, Lai CS, He K, Zhou Z, Zhang L, Quan Z, Zhu N, Zheng QY, Pan MH, Ho CT (2006) Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J Nat Prod 69(4):531–535CrossRef Bai N, Lai CS, He K, Zhou Z, Zhang L, Quan Z, Zhu N, Zheng QY, Pan MH, Ho CT (2006) Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines. J Nat Prod 69(4):531–535CrossRef
Zurück zum Zitat Breyer MD, Bottinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, Sharma K, AMDCC (2005) Mouse models of diabetic nephropathy. J Am Soc Nephrol 16(1):27–45CrossRef Breyer MD, Bottinger E, Brosius FC, Coffman TM, Harris RC, Heilig CW, Sharma K, AMDCC (2005) Mouse models of diabetic nephropathy. J Am Soc Nephrol 16(1):27–45CrossRef
Zurück zum Zitat Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T (2009) Mouse models of diabetic nephropathy. J Am Soc Nephrol 20(12):2503–2512CrossRef Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T (2009) Mouse models of diabetic nephropathy. J Am Soc Nephrol 20(12):2503–2512CrossRef
Zurück zum Zitat Faramarzi E, Zangeneh MM, Zangeneh A, Moradi R (2017) Effect of Cinnamomum zelanicumon oil on hyponeophagia anxiety test in Balb C male mice. Onl J Vet Res 21(2):77–80 Faramarzi E, Zangeneh MM, Zangeneh A, Moradi R (2017) Effect of Cinnamomum zelanicumon oil on hyponeophagia anxiety test in Balb C male mice. Onl J Vet Res 21(2):77–80
Zurück zum Zitat Foroughi A, Pournaghi P, Najafi F, Zangeneh A, Zangeneh MM, Moradi R (2016) Antibacterial effect and phytochemical screening of essential oil of Pimpinella anisum against Escherichia coli O157:H7 and Staphylococcus aureus. Int J Current Med Pharm Res 7(6):367–371 Foroughi A, Pournaghi P, Najafi F, Zangeneh A, Zangeneh MM, Moradi R (2016) Antibacterial effect and phytochemical screening of essential oil of Pimpinella anisum against Escherichia coli O157:H7 and Staphylococcus aureus. Int J Current Med Pharm Res 7(6):367–371
Zurück zum Zitat Foroughi A, Pournaghi P, Najafi F, Zangeneh A, Zangeneh MM, Moradi R (2017) Medicinal plants: antibacterial effects and chemical composition of essential oil of Foeniculum vulgare. Int J Curr Pharm Rew Res 8(1):13–17 Foroughi A, Pournaghi P, Najafi F, Zangeneh A, Zangeneh MM, Moradi R (2017) Medicinal plants: antibacterial effects and chemical composition of essential oil of Foeniculum vulgare. Int J Curr Pharm Rew Res 8(1):13–17
Zurück zum Zitat Ghashghaii A, Hashemnia M, Nikousefat Z, Zangeneh MM, Zangeneh A (2017) Wound healing potential of methanolic extract of Scrophularia striata in rats. Pharm Sci 23(4):256–263CrossRef Ghashghaii A, Hashemnia M, Nikousefat Z, Zangeneh MM, Zangeneh A (2017) Wound healing potential of methanolic extract of Scrophularia striata in rats. Pharm Sci 23(4):256–263CrossRef
Zurück zum Zitat Goodarzi N, Zangeneh MM, Zangeneh A (2018) The effect of ethanolic extract of Allium Saralicum R.M. Fritsch on diabetic hepatopathy in male mice. Sci Res J Shahed Univ 25(132):21–30 Goodarzi N, Zangeneh MM, Zangeneh A (2018) The effect of ethanolic extract of Allium Saralicum R.M. Fritsch on diabetic hepatopathy in male mice. Sci Res J Shahed Univ 25(132):21–30
Zurück zum Zitat Goodarzi N, Zangeneh MM, Zangeneh A, Najafi F, Tahvilian R (2017) Protective effects of ethanolic extract of Allium Saralicum R.M. Fritsch on CCl4- induced hepatotoxicity in mice. J Rafsanjan Univ Med Sci 16(3):227–238 Goodarzi N, Zangeneh MM, Zangeneh A, Najafi F, Tahvilian R (2017) Protective effects of ethanolic extract of Allium Saralicum R.M. Fritsch on CCl4- induced hepatotoxicity in mice. J Rafsanjan Univ Med Sci 16(3):227–238
Zurück zum Zitat Goorani S, Zangeneh MM, Zangeneh A, Poorshamohammad C, Abiari M, Moradi R, Najafi F, Tahvilian R (2018) Study of wound healing potential of Stevia rebaudiana ethanol extract in male rats. Res J Pharmacogn 5(1):23–30 Goorani S, Zangeneh MM, Zangeneh A, Poorshamohammad C, Abiari M, Moradi R, Najafi F, Tahvilian R (2018) Study of wound healing potential of Stevia rebaudiana ethanol extract in male rats. Res J Pharmacogn 5(1):23–30
Zurück zum Zitat Hagh-Nazari L, Goodarzi N, Zangeneh MM, Zangeneh A, Tahvilian R, Moradi R (2017) Stereological study of kidney in streptozotocin-induced diabetic mice treated with ethanolic extract of Stevia rebaudiana (bitter fraction). Comp Clin Pathol 26(2):455–463CrossRef Hagh-Nazari L, Goodarzi N, Zangeneh MM, Zangeneh A, Tahvilian R, Moradi R (2017) Stereological study of kidney in streptozotocin-induced diabetic mice treated with ethanolic extract of Stevia rebaudiana (bitter fraction). Comp Clin Pathol 26(2):455–463CrossRef
Zurück zum Zitat Halliwell B, Gutteridge J (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219(1):1–14CrossRef Halliwell B, Gutteridge J (1984) Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219(1):1–14CrossRef
Zurück zum Zitat Huff GR, Huff WE, Balog JM, Rath NC, Anthony NB, Nestor KE (2005) Stress response differences and disease susceptibility reflected by Heterophil to lymphocyte ratio in turkeys selected for increased body weight. Poult Sci 84(5):709–717CrossRef Huff GR, Huff WE, Balog JM, Rath NC, Anthony NB, Nestor KE (2005) Stress response differences and disease susceptibility reflected by Heterophil to lymphocyte ratio in turkeys selected for increased body weight. Poult Sci 84(5):709–717CrossRef
Zurück zum Zitat Jaberian H, Piri K, Nazari J (2013) Phytochemical composition and in vitro antimicrobial and antioxidant activities of some medicinal plants. Food Chem 136(1):237–244CrossRef Jaberian H, Piri K, Nazari J (2013) Phytochemical composition and in vitro antimicrobial and antioxidant activities of some medicinal plants. Food Chem 136(1):237–244CrossRef
Zurück zum Zitat Khan AL, Hussain J, Hamayun M, Gilani SA, Ahmad S, Rehman G, Kim YH, Kang SM, Lee IJ (2010) Secondary metabolites from Inula britannica L. and their biological activities. Molecules 15(3):1562–1577CrossRef Khan AL, Hussain J, Hamayun M, Gilani SA, Ahmad S, Rehman G, Kim YH, Kang SM, Lee IJ (2010) Secondary metabolites from Inula britannica L. and their biological activities. Molecules 15(3):1562–1577CrossRef
Zurück zum Zitat Khanahmadi M, Shahrezaei F (2008) Review and identify the chemical constituents of volatile oils of Falcaria vulgaris Bernh. J Med Plants 6(3):52–57 Khanahmadi M, Shahrezaei F (2008) Review and identify the chemical constituents of volatile oils of Falcaria vulgaris Bernh. J Med Plants 6(3):52–57
Zurück zum Zitat Kobayashi T, Song QH, Hong T, Kitamura H, Cyong JC (2002) Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin. Phytother Res 16(4):377–382CrossRef Kobayashi T, Song QH, Hong T, Kitamura H, Cyong JC (2002) Preventative effects of the flowers of Inula britannica on autoimmune diabetes in C57BL/KsJ mice induced by multiple low doses of streptozotocin. Phytother Res 16(4):377–382CrossRef
Zurück zum Zitat Kraynak AR, Storer RD, Jensen RD, Kloss MW, Soper KA, Clair JH, DeLuca JG, Nichols WW, Eydelloth RS (1995) Extent and persistence of streptozotocin-induced DNAdamage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays. Toxicol Appl Pharmacol 135(2):279–286CrossRef Kraynak AR, Storer RD, Jensen RD, Kloss MW, Soper KA, Clair JH, DeLuca JG, Nichols WW, Eydelloth RS (1995) Extent and persistence of streptozotocin-induced DNAdamage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays. Toxicol Appl Pharmacol 135(2):279–286CrossRef
Zurück zum Zitat Larson CT, Gross WB, Davis JW (1985) Social stress and resistance of chicken and swine to Staphylococcus aureus challenge infections. Can J Comp Med 49(2):208–210PubMedPubMedCentral Larson CT, Gross WB, Davis JW (1985) Social stress and resistance of chicken and swine to Staphylococcus aureus challenge infections. Can J Comp Med 49(2):208–210PubMedPubMedCentral
Zurück zum Zitat Le-Devehat C, Khodabandehlou T, Vimeux M (2001) Impaired hemorheological properties in diabetic patients with lower limb arterial ischaemia. Clin Hemorheol Microcirc 25(2):43–48PubMed Le-Devehat C, Khodabandehlou T, Vimeux M (2001) Impaired hemorheological properties in diabetic patients with lower limb arterial ischaemia. Clin Hemorheol Microcirc 25(2):43–48PubMed
Zurück zum Zitat Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51(2):216–226CrossRef Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51(2):216–226CrossRef
Zurück zum Zitat Mandarim-de-Lacerda CA (2003) Stereological tools in biomedical research. An Acad Bras Cienc 5(4):469–486CrossRef Mandarim-de-Lacerda CA (2003) Stereological tools in biomedical research. An Acad Bras Cienc 5(4):469–486CrossRef
Zurück zum Zitat Martin JP Jr, Dailey M, Sugarman E (1987) Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys 255(2):329–336CrossRef Martin JP Jr, Dailey M, Sugarman E (1987) Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch Biochem Biophys 255(2):329–336CrossRef
Zurück zum Zitat Moradi R, Hajialiani M, Zangeneh MM, Zangeneh A, Tahvilian R, Hidaryan H, Rezaeeasl N, Kohneshin A (2017) Antibacterial properties of an Iranian Ethnomedicinal plant. Int J Ayu Pharm Chem 6(3):128–137 Moradi R, Hajialiani M, Zangeneh MM, Zangeneh A, Tahvilian R, Hidaryan H, Rezaeeasl N, Kohneshin A (2017) Antibacterial properties of an Iranian Ethnomedicinal plant. Int J Ayu Pharm Chem 6(3):128–137
Zurück zum Zitat Najafi F, Goodarzi N, Zangeneh MM, Zangeneh A, Hagh-Nazari L (2017) Antidiabtic and hepatoprotective effects of bitter fraction of Stevia rebaudiana alcoholic extract on streptozotocin-induced diabetic male mice. J Rafsanjan Univ Med Sci 16(6):493–504 Najafi F, Goodarzi N, Zangeneh MM, Zangeneh A, Hagh-Nazari L (2017) Antidiabtic and hepatoprotective effects of bitter fraction of Stevia rebaudiana alcoholic extract on streptozotocin-induced diabetic male mice. J Rafsanjan Univ Med Sci 16(6):493–504
Zurück zum Zitat Najafi F, Tahvilian R, Zangeneh MM, Zangeneh A, Moradi R (2016) Screening of essential oil of Allium sativum for antibacterial effects against Bacillus subtilis. Int J Rec Sci Res 7(11):14172–14176 Najafi F, Tahvilian R, Zangeneh MM, Zangeneh A, Moradi R (2016) Screening of essential oil of Allium sativum for antibacterial effects against Bacillus subtilis. Int J Rec Sci Res 7(11):14172–14176
Zurück zum Zitat Nyengaard JR (1999) Stereologic methods and their application in kidney research. J Am Soc Nephrol 10(5):1100–1123PubMed Nyengaard JR (1999) Stereologic methods and their application in kidney research. J Am Soc Nephrol 10(5):1100–1123PubMed
Zurück zum Zitat Palm F, Ortster H, Hansell P, Liss P, Carlsson PO (2004) Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin diabetic rat model. Diabetes Metab Res Rev 20(6):452–459CrossRef Palm F, Ortster H, Hansell P, Liss P, Carlsson PO (2004) Differentiating between effects of streptozotocin per se and subsequent hyperglycemia on renal function and metabolism in the streptozotocin diabetic rat model. Diabetes Metab Res Rev 20(6):452–459CrossRef
Zurück zum Zitat Poorshamohammad C, Souri N, Amini Z, Kosari F, Jamshidpour R, Zangeneh MM, Zangeneh A (2017) Cucurbita moschata: a plant with antibacterial properties. Int J Current Med Pharm Res 3(2):1356–1359 Poorshamohammad C, Souri N, Amini Z, Kosari F, Jamshidpour R, Zangeneh MM, Zangeneh A (2017) Cucurbita moschata: a plant with antibacterial properties. Int J Current Med Pharm Res 3(2):1356–1359
Zurück zum Zitat Pooyanmehr M, Zangeneh MM, Zangeneh A, Almasi M (2017) Effect of Verbascum thapsus aqueous extract on Escherichia coli O157:H7. Onl J Vet Res 21(9):580–583 Pooyanmehr M, Zangeneh MM, Zangeneh A, Almasi M (2017) Effect of Verbascum thapsus aqueous extract on Escherichia coli O157:H7. Onl J Vet Res 21(9):580–583
Zurück zum Zitat Recknagel RO, GlendeJr EA, Britton RS (1991) Free radical damage and lipid peroxidation. In: Meeks RG (ed) Hepatotoxicology. CRC Press, Florida, pp 401–436 Recknagel RO, GlendeJr EA, Britton RS (1991) Free radical damage and lipid peroxidation. In: Meeks RG (ed) Hepatotoxicology. CRC Press, Florida, pp 401–436
Zurück zum Zitat Rerup CC (1970) Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 22(4):485–518PubMed Rerup CC (1970) Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 22(4):485–518PubMed
Zurück zum Zitat Roy A, Bhoumik D, Sahu RK, Dwivedi J (2014) Medicinal plants used in liver protection - a review. UK J Pharm Biosci 2(1):23–33CrossRef Roy A, Bhoumik D, Sahu RK, Dwivedi J (2014) Medicinal plants used in liver protection - a review. UK J Pharm Biosci 2(1):23–33CrossRef
Zurück zum Zitat Saba AB, Oyagbemi AA, Azeez OI (2010) Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats. Nig J Physiol Sci 25(2):139–147 Saba AB, Oyagbemi AA, Azeez OI (2010) Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats. Nig J Physiol Sci 25(2):139–147
Zurück zum Zitat Seca AM, Grigore A, Pinto DC, Silva AM (2014) The genus Inula and their metabolites: from ethnopharmacological to medicinal uses. J Ethnopharmacol 154(2):286–310CrossRef Seca AM, Grigore A, Pinto DC, Silva AM (2014) The genus Inula and their metabolites: from ethnopharmacological to medicinal uses. J Ethnopharmacol 154(2):286–310CrossRef
Zurück zum Zitat Shafaghat A (2011) Volatile oil constituents and antibacterial activity of different parts of Falcaria vulgaris Bernh. Growing wild in two localities from Iran. Nat Prod Res 25(4):368–373CrossRef Shafaghat A (2011) Volatile oil constituents and antibacterial activity of different parts of Falcaria vulgaris Bernh. Growing wild in two localities from Iran. Nat Prod Res 25(4):368–373CrossRef
Zurück zum Zitat Sherkatolabbasieh H, Hagh-Nazari L, Shafiezadeh S, Goodarzi N, Zangeneh MM, Zangeneh A (2017) Ameliorative effect of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced nephrotoxicity in mice: a stereological examination. Arch Biol Sci 69(3):535–543CrossRef Sherkatolabbasieh H, Hagh-Nazari L, Shafiezadeh S, Goodarzi N, Zangeneh MM, Zangeneh A (2017) Ameliorative effect of the ethanolic extract of Allium saralicum R.M. Fritsch on CCl4-induced nephrotoxicity in mice: a stereological examination. Arch Biol Sci 69(3):535–543CrossRef
Zurück zum Zitat Shojaii A, Hashem-Dabaghian F, Goushegir A, Abdollahi-Fard M (2011) Antidiabetic plants of Iran. Acta Medica Iranica 49(10):637–642PubMed Shojaii A, Hashem-Dabaghian F, Goushegir A, Abdollahi-Fard M (2011) Antidiabetic plants of Iran. Acta Medica Iranica 49(10):637–642PubMed
Zurück zum Zitat Swenson MJ (1993) Physiological properties and cellular and chemical constituent of blood. In: Dukes’ Physiology of domestic animals. Comstock Publishing Associates, Ithaca and London, pp 29–32 Swenson MJ (1993) Physiological properties and cellular and chemical constituent of blood. In: Dukes’ Physiology of domestic animals. Comstock Publishing Associates, Ithaca and London, pp 29–32
Zurück zum Zitat Tahvilian R, Moradi R, Hajialian M, Zangeneh MM, Zangeneh A, Yazdani H, Zhale H (2017) Evaluation of antibacterial properties of essential oil of Pistacia khinjuk. Int J Res Pharm Sci 7(1):1–6 Tahvilian R, Moradi R, Hajialian M, Zangeneh MM, Zangeneh A, Yazdani H, Zhale H (2017) Evaluation of antibacterial properties of essential oil of Pistacia khinjuk. Int J Res Pharm Sci 7(1):1–6
Zurück zum Zitat Tay YC, Wang Y, Kairaitis L, Rangan GK, Zhang C, Harris DCH (2005) Can murine diabetic nephropathy be separated from superimposed acute renal failure? Kidney Int 68(1):391–398CrossRef Tay YC, Wang Y, Kairaitis L, Rangan GK, Zhang C, Harris DCH (2005) Can murine diabetic nephropathy be separated from superimposed acute renal failure? Kidney Int 68(1):391–398CrossRef
Zurück zum Zitat Tesch GH, Allen TJ (2007) Rodent models of streptozotocininduced diabetic nephropathy. Nephrology (Carlton) 12(3):261–266CrossRef Tesch GH, Allen TJ (2007) Rodent models of streptozotocininduced diabetic nephropathy. Nephrology (Carlton) 12(3):261–266CrossRef
Zurück zum Zitat Weiss RB (1982) Streptozocin: a review of its pharmacology, efficacy, and toxicity. Cancer Treat Rep 66(3):427–438PubMed Weiss RB (1982) Streptozocin: a review of its pharmacology, efficacy, and toxicity. Cancer Treat Rep 66(3):427–438PubMed
Zurück zum Zitat Zangar RC, Benson JM, Burnett VL, Springer DL (2000) Cytochrome P4502E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem Biol Interact 125(3):233–243CrossRef Zangar RC, Benson JM, Burnett VL, Springer DL (2000) Cytochrome P4502E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes. Chem Biol Interact 125(3):233–243CrossRef
Zurück zum Zitat Zangeneh A, Zangeneh MM, Hajialiani M, Moradi R, Nazari F, Sanjabi Shirazi F, Ansari N, Lotfi-Hamadani M, Ekhtiari A (2017) Peruse a plant product as an antimicrobial agent. Int J Current Med Pharm Res 3(2):1348–1351 Zangeneh A, Zangeneh MM, Hajialiani M, Moradi R, Nazari F, Sanjabi Shirazi F, Ansari N, Lotfi-Hamadani M, Ekhtiari A (2017) Peruse a plant product as an antimicrobial agent. Int J Current Med Pharm Res 3(2):1348–1351
Zurück zum Zitat Zangeneh MM, Goodarzi N, Zangeneh A, Najafi F, Tahvilian (2018) Hypoglycemic and nephroprotective effects of aqueous extract of Stevia rebaudiana (sweet fraction) in streptozotocin-induced diabetic mice. J Ardabil Univ Med Sci 17(4):437–446 Zangeneh MM, Goodarzi N, Zangeneh A, Najafi F, Tahvilian (2018) Hypoglycemic and nephroprotective effects of aqueous extract of Stevia rebaudiana (sweet fraction) in streptozotocin-induced diabetic mice. J Ardabil Univ Med Sci 17(4):437–446
Metadaten
Titel
A comparative study of hepatoprotective effect of Inula britannica L aqueous extract and glibenclamide in streptozotocin-induced diabetic mice
verfasst von
Mohammad Mahdi Zangeneh
Akram Zangeneh
Maryam Almasi
Reza Tahvilian
Fariba Hosseini
Rohallah Moradi
Publikationsdatum
04.07.2018
Verlag
Springer London
Erschienen in
Comparative Clinical Pathology / Ausgabe 6/2018
Print ISSN: 1618-5641
Elektronische ISSN: 1618-565X
DOI
https://doi.org/10.1007/s00580-018-2789-z

Weitere Artikel der Ausgabe 6/2018

Comparative Clinical Pathology 6/2018 Zur Ausgabe

Neu im Fachgebiet Pathologie