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Erschienen in: Surgery Today 2/2017

09.06.2016 | Original Article

A comparative study on the complications of conventional and end-to-side inserting pancreatojejunostomy after pancreaticoduodenectomy

verfasst von: Daisuke Hashimoto, Akira Chikamoto, Norifumi Harimoto, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Hideo Baba, Yoshihiko Maehara

Erschienen in: Surgery Today | Ausgabe 2/2017

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Abstract

Purpose

Pancreatico-digestive anastomosis is important in ensuring the safety of pancreaticoduodenectomy. This study compared the postoperative complications of a newly developed method of inserting end-to-side pancreaticojejunostomy with the conventional pancreaticojejunostomy after pancreaticoduodenectomy.

Methods

From April 2012 to December 2015, 108 consecutive patients underwent pancreaticoduodenectomy at Kumamoto University Hospital. A modified child’s reconstruction was performed with the inserting or conventional pancreaticojejunostomy. The clinical course and the incidence of postoperative complications were retrospectively evaluated.

Results

Five patients were excluded, four who underwent hepato-pancreatoduodenectomy and one who did not require pancreaticojejunostomy because of an atrophic pancreatic remnant. Of the 103 patients that were included in the analysis, 41 and 62 underwent surgery with the inserting and conventional methods, respectively. The incidence of postoperative Clavien–Dindo grade > II complications was similar in the two groups [36.6 % (15/41) vs 27.4 % (17/62)]. However, the rates of grade C postoperative pancreatic fistula [7.3 % (3/41) vs 0 % (0/62) P = 0.030] and re-operation for postoperative complications [14.6 % (6/41) vs 3.2 % (2/62), P = 0.034] were significantly higher in the inserting group than in the conventional group. There were no in-hospital deaths in either group.

Conclusions

The conventional pancreaticojejunostomy is safer than the end-to-side inserting pancreaticojejunostomy, as the latter is associated with a risk of severe complications. Improvements in pancreatico-digestive anastomosis techniques are required.
Literatur
1.
Zurück zum Zitat Hashimoto D, Chikamoto A, Ohmuraya M, Hirota M, Baba H. Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy. Surg Today. 2014;44:1207–13.CrossRefPubMed Hashimoto D, Chikamoto A, Ohmuraya M, Hirota M, Baba H. Pancreaticodigestive anastomosis and the postoperative management strategies to prevent postoperative pancreatic fistula formation after pancreaticoduodenectomy. Surg Today. 2014;44:1207–13.CrossRefPubMed
2.
Zurück zum Zitat Miyata H, Gotoh M, Hirai I, Kenjo A, Kitagawa Y, Shimada M, et al. A pancreaticoduodenectomy risk model derived from 8575 cases from a national single-race population (Japanese) using a web-based data entry system: the 30-day and in-hospital mortality rates for pancreaticoduodenectomy. Ann Surg. 2014;259:773–80.CrossRefPubMed Miyata H, Gotoh M, Hirai I, Kenjo A, Kitagawa Y, Shimada M, et al. A pancreaticoduodenectomy risk model derived from 8575 cases from a national single-race population (Japanese) using a web-based data entry system: the 30-day and in-hospital mortality rates for pancreaticoduodenectomy. Ann Surg. 2014;259:773–80.CrossRefPubMed
3.
Zurück zum Zitat Sugiura T, Mizuno T, Okamura Y, Ito T, Yamamoto Y, Kawamura I, et al. Impact of bacterial contamination of the abdominal cavity during pancreaticoduodenectomy on surgical-site infection. Br J Surg. 2015;102:1561–6.CrossRefPubMed Sugiura T, Mizuno T, Okamura Y, Ito T, Yamamoto Y, Kawamura I, et al. Impact of bacterial contamination of the abdominal cavity during pancreaticoduodenectomy on surgical-site infection. Br J Surg. 2015;102:1561–6.CrossRefPubMed
4.
Zurück zum Zitat Arima K, Hashimoto D, Okabe H, Inoue R, Kaida T, Higashi T, et al. Intraoperative blood loss is not a predictor of prognosis for pancreatic cancer. Surg Today. 2016;46(7):792–7.CrossRefPubMed Arima K, Hashimoto D, Okabe H, Inoue R, Kaida T, Higashi T, et al. Intraoperative blood loss is not a predictor of prognosis for pancreatic cancer. Surg Today. 2016;46(7):792–7.CrossRefPubMed
5.
Zurück zum Zitat Asari S, Matsumoto I, Toyama H, Shinzeki M, Goto T, Ishida J, et al. Preoperative independent prognostic factors in patients with borderline resectable pancreatic ductal adenocarcinoma following curative resection: the neutrophil-lymphocyte and platelet-lymphocyte ratios. Surg Today. 2016;46:583–92.CrossRefPubMed Asari S, Matsumoto I, Toyama H, Shinzeki M, Goto T, Ishida J, et al. Preoperative independent prognostic factors in patients with borderline resectable pancreatic ductal adenocarcinoma following curative resection: the neutrophil-lymphocyte and platelet-lymphocyte ratios. Surg Today. 2016;46:583–92.CrossRefPubMed
6.
Zurück zum Zitat Fernández-Cruz L, Belli A, Acosta M, Chavarria EJ, Adelsdorfer W, López-Boado MA, et al. Which is the best technique for pancreaticoenteric reconstruction after pancreaticoduodenectomy? A critical analysis. Surg Today. 2011;41:761–6.CrossRefPubMed Fernández-Cruz L, Belli A, Acosta M, Chavarria EJ, Adelsdorfer W, López-Boado MA, et al. Which is the best technique for pancreaticoenteric reconstruction after pancreaticoduodenectomy? A critical analysis. Surg Today. 2011;41:761–6.CrossRefPubMed
7.
Zurück zum Zitat Kawai M, Yamaue H. Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today. 2010;40:1011–7.CrossRefPubMed Kawai M, Yamaue H. Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today. 2010;40:1011–7.CrossRefPubMed
8.
Zurück zum Zitat Motoi F, Egawa S, Rikiyama T, Katayose Y, Unno M. Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg. 2012;99:524–31.CrossRefPubMed Motoi F, Egawa S, Rikiyama T, Katayose Y, Unno M. Randomized clinical trial of external stent drainage of the pancreatic duct to reduce postoperative pancreatic fistula after pancreaticojejunostomy. Br J Surg. 2012;99:524–31.CrossRefPubMed
9.
Zurück zum Zitat Hirota M. Percutaneous transfistulous interventions for intractable pancreatic fistula. Radiol Res Pract. 2011;2011:109259.PubMedPubMedCentral Hirota M. Percutaneous transfistulous interventions for intractable pancreatic fistula. Radiol Res Pract. 2011;2011:109259.PubMedPubMedCentral
10.
Zurück zum Zitat Hirota M, Kanemitsu K, Takamori H, Chikamoto A, Hayashi N, Horino K, et al. Percutaneous transfistulous pancreatic duct drainage and interventional pancreatojejunostomy as a treatment option for intractable pancreatic fistula. Am J Surg. 2008;196:280–4.CrossRefPubMed Hirota M, Kanemitsu K, Takamori H, Chikamoto A, Hayashi N, Horino K, et al. Percutaneous transfistulous pancreatic duct drainage and interventional pancreatojejunostomy as a treatment option for intractable pancreatic fistula. Am J Surg. 2008;196:280–4.CrossRefPubMed
11.
Zurück zum Zitat Hashimoto D, Takamori H, Sakamoto Y, Ikuta Y, Nakahara O, Furuhashi S, et al. Is an estimation of physiologic ability and surgical stress able to predict operative morbidity after pancreaticoduodenectomy? J Hepatobiliary Pancreat Sci. 2010;17:132–8.CrossRefPubMed Hashimoto D, Takamori H, Sakamoto Y, Ikuta Y, Nakahara O, Furuhashi S, et al. Is an estimation of physiologic ability and surgical stress able to predict operative morbidity after pancreaticoduodenectomy? J Hepatobiliary Pancreat Sci. 2010;17:132–8.CrossRefPubMed
12.
Zurück zum Zitat Lämsä T, Jin HT, Nordback PH, Sand J, Luukkaala T, Nordback I. Pancreatic injury response is different depending on the method of resecting the parenchyma. J Surg Res. 2009;154:203–11.CrossRefPubMed Lämsä T, Jin HT, Nordback PH, Sand J, Luukkaala T, Nordback I. Pancreatic injury response is different depending on the method of resecting the parenchyma. J Surg Res. 2009;154:203–11.CrossRefPubMed
13.
Zurück zum Zitat Peng SY, Wang JW, Li JT, Mou YP, Liu YB, Cai XJ. Binding pancreaticojejunostomy—a safe and reliable anastomosis procedure. HPB (Oxford). 2004;6:154–60.CrossRefPubMedPubMedCentral Peng SY, Wang JW, Li JT, Mou YP, Liu YB, Cai XJ. Binding pancreaticojejunostomy—a safe and reliable anastomosis procedure. HPB (Oxford). 2004;6:154–60.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Nordback I, Lämsä T, Laukkarinen J, Leppiniemi J, Kellomäki M, Sand J. Pancreatico-jejunostomy with a biodegradable pancreatic stent and without stitches through the pancreas. Hepatogastroenterology. 2008;55:319–22.PubMed Nordback I, Lämsä T, Laukkarinen J, Leppiniemi J, Kellomäki M, Sand J. Pancreatico-jejunostomy with a biodegradable pancreatic stent and without stitches through the pancreas. Hepatogastroenterology. 2008;55:319–22.PubMed
15.
Zurück zum Zitat Peng SY, Wang JW, Lau WY, Cai XJ, Mou YP, Liu YB, et al. Conventional versus binding pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. Ann Surg. 2007;245:692–8.CrossRefPubMedPubMedCentral Peng SY, Wang JW, Lau WY, Cai XJ, Mou YP, Liu YB, et al. Conventional versus binding pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. Ann Surg. 2007;245:692–8.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Hashimoto D, Hirota M, Yagi Y, Baba H. End-to-side pancreaticojejunostomy without stitches in the pancreatic stump. Surg Today. 2013;43:821–4.CrossRefPubMed Hashimoto D, Hirota M, Yagi Y, Baba H. End-to-side pancreaticojejunostomy without stitches in the pancreatic stump. Surg Today. 2013;43:821–4.CrossRefPubMed
17.
Zurück zum Zitat DeOliveira ML, Winter JM, Schafer M, Cunningham SC, Cameron JL, Yeo CJ, et al. Assessment of complications after pancreatic surgery: a novel grading system applied to 633 patients undergoing pancreaticoduodenectomy. Ann Surg. 2006;244:931–7 (discussion 9).CrossRefPubMedPubMedCentral DeOliveira ML, Winter JM, Schafer M, Cunningham SC, Cameron JL, Yeo CJ, et al. Assessment of complications after pancreatic surgery: a novel grading system applied to 633 patients undergoing pancreaticoduodenectomy. Ann Surg. 2006;244:931–7 (discussion 9).CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138:8–13.CrossRefPubMed Bassi C, Dervenis C, Butturini G, Fingerhut A, Yeo C, Izbicki J, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138:8–13.CrossRefPubMed
19.
Zurück zum Zitat Japan Pancreas Society. General rules for the study of pancreatic cancer. 6th ed. Tokyo: Kanehara; 2009. Japan Pancreas Society. General rules for the study of pancreatic cancer. 6th ed. Tokyo: Kanehara; 2009.
20.
Zurück zum Zitat Japanese society of biliary surgery. Society General rules for surgical and pathological studies on cancer of the biliary tract. 5th ed. Kanehara: Tokyo; 2003. Japanese society of biliary surgery. Society General rules for surgical and pathological studies on cancer of the biliary tract. 5th ed. Kanehara: Tokyo; 2003.
21.
Zurück zum Zitat Wente MN, Veit JA, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, et al. Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery. 2007;142:20–5.CrossRefPubMed Wente MN, Veit JA, Bassi C, Dervenis C, Fingerhut A, Gouma DJ, et al. Postpancreatectomy hemorrhage (PPH): an International Study Group of Pancreatic Surgery (ISGPS) definition. Surgery. 2007;142:20–5.CrossRefPubMed
22.
Zurück zum Zitat Menahem B, Guittet L, Mulliri A, Alves A, Lubrano J. Pancreaticogastrostomy is superior to pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: an updated meta-analysis of randomized controlled trials. Ann Surg. 2015;261:882–7.CrossRefPubMed Menahem B, Guittet L, Mulliri A, Alves A, Lubrano J. Pancreaticogastrostomy is superior to pancreaticojejunostomy for prevention of pancreatic fistula after pancreaticoduodenectomy: an updated meta-analysis of randomized controlled trials. Ann Surg. 2015;261:882–7.CrossRefPubMed
23.
Zurück zum Zitat Peng SY, Wang JW, de Hong F, Liu YB, Wang YF. Binding pancreaticoenteric anastomosis: from binding pancreaticojejunostomy to binding pancreaticogastrostomy. Updates Surg. 2011;63:69–74.CrossRefPubMed Peng SY, Wang JW, de Hong F, Liu YB, Wang YF. Binding pancreaticoenteric anastomosis: from binding pancreaticojejunostomy to binding pancreaticogastrostomy. Updates Surg. 2011;63:69–74.CrossRefPubMed
24.
Zurück zum Zitat Suzuki O, Hirano S, Yano T, Okamura K, Hazama K, Shichinohe T, et al. Laparoscopic pancreaticoduodenectomy is effective in a porcine model. Surg Endosc. 2008;22:2509–13.CrossRefPubMed Suzuki O, Hirano S, Yano T, Okamura K, Hazama K, Shichinohe T, et al. Laparoscopic pancreaticoduodenectomy is effective in a porcine model. Surg Endosc. 2008;22:2509–13.CrossRefPubMed
25.
Zurück zum Zitat Cui X, Lei P, Liu S, Liu X, Wu Z, Lv Y. A sutureless method for digestive tract reconstruction during pancreaticoduodenectomy in a dog model. Int J Clin Exp Med. 2015;8:289–96.PubMedPubMedCentral Cui X, Lei P, Liu S, Liu X, Wu Z, Lv Y. A sutureless method for digestive tract reconstruction during pancreaticoduodenectomy in a dog model. Int J Clin Exp Med. 2015;8:289–96.PubMedPubMedCentral
Metadaten
Titel
A comparative study on the complications of conventional and end-to-side inserting pancreatojejunostomy after pancreaticoduodenectomy
verfasst von
Daisuke Hashimoto
Akira Chikamoto
Norifumi Harimoto
Toru Ikegami
Hideaki Uchiyama
Tomoharu Yoshizumi
Hideo Baba
Yoshihiko Maehara
Publikationsdatum
09.06.2016
Verlag
Springer Japan
Erschienen in
Surgery Today / Ausgabe 2/2017
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-016-1364-y

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