Background
Methods
Participants
Health utility measures
EQ-5D-3L
EQ-5D visual analogue scale
SF-6D
SF-12 New algorithm instrument
Depression measure
Statistical analysis
Agreement
Sensitivity
Responsiveness to change
Acceptability
Results
Characteristic | EQ-5D-3L | EQ-5D VAS | SF-6D | SF-12 new algorithm |
---|---|---|---|---|
(n=395) | (n=394) | (n=393) | (n=393) | |
Age
| ||||
mean (SD)
| 50.0 (11.6) | 50.0 (11.6) | 49.9 (11.6) | 49.9 (11.6) |
Gender
| ||||
Female n (%)
| 293 (74.2%) | 293 (74.4%) | 291 (74.1%) | 291 (74.1%) |
Male n (%)
| 102 (25.8%) | 101 (25.6%) | 102 (25.9%) | 102 (25.9%) |
Suffered from depression in the past
| ||||
Yes | 353 (89.4%) | 352 (89.3%) | 351 (89.3%) | 351 (89.3%) |
No | 42 (10.6%) | 42 (10.7%) | 42 (10.7%) | 42 (10.7%) |
Duration of current episode of depression
| ||||
<2 years | 95 (24.1%) | 95 (24.1%) | 94 (23.9%) | 94 (23.9%) |
1-2 years | 70 (17.7%) | 70 (17.8%) | 70 (17.8%) | 70 (17.8%) |
>2 years | 230 (58.2%) | 229 (58.1%) | 229 (58.3%) | 229 (58.3%) |
BDI score at baseline
| ||||
mean (SD)
| 31.3 (10.4) | 31.3 (10.4) | 31.2 (10.4) | 31.2 (10.4) |
BDI score at 12 months
| ||||
mean (SD)
| 19.3 (13.6) | 19.3 (13.7) | 19.2 (13.5) | 19.2 (13.5) |
Health utility score at baseline*
| ||||
mean (SD)
| 0.55 (0.31) | 0.51 (0.20) | 0.56 (0.11) | 0.57 (0.08) |
Health utility score at 12 months
| ||||
mean (SD)
| 0.60 (0.35) | 0.59 (0.25) | 0.62 (0.16) | 0.62 (0.14) |
Agreement
Sensitivity
Depression severity groups | Utility score means by depression severity group mean (SD)
| Mean difference in health utility score | Tukey-Kramer test statistic (critical value = 3.649)^ | |
---|---|---|---|---|
EQ-5D-3L:
| ||||
Not depressed vs Mild depression | 0.797 (0.226) | 0.670 (0.243) | 0.128 | 4.242* |
Mild depression vs Moderate depression | 0.670 (0.243) | 0.557 (0.295) | 0.112 | 3.272 |
Moderate depression vs Severe depression | 0.557 (0.295) | 0.268 (0.352) | 0.289 | 9.641* |
EQ-5D VAS:
| ||||
Not depressed vs Mild depression | 0.713 (0.239) | 0.586 (0.229) | 0.127 | 5.247* |
Mild depression vs Moderate depression | 0.586 (0.229) | 0.561 (0.209) | 0.025 | 0.901 |
Moderate depression vs Severe depression | 0.561 (0.209) | 0.422 (0.211) | 0.139 | 5.693* |
SF-6D:
| ||||
Not depressed vs Mild depression | 0.725 (0.137) | 0.624 (0.119) | 0.102 | 7.843* |
Mild depression vs Moderate depression | 0.624 (0.119) | 0.554 (0.096) | 0.070 | 4.733* |
Moderate depression vs Severe depression | 0.554 (0.096) | 0.482 (0.107) | 0.072 | 5.505* |
SF-12 new algorithm:
| ||||
Not depressed vs Mild depression | 0.732 (0.139) | 0.617 (0.096) | 0.116 | 9.796* |
Mild depression vs Moderate depression | 0.617 (0.096) | 0.564 (0.073) | 0.053 | 3.927* |
Moderate depression vs Severe depression | 0.564 (0.073) | 0.505 (0.083) | 0.059 | 4.947* |
Responsiveness to change
Utility instrument | Area under the ROC curve | 95% confidence interval |
---|---|---|
EQ-5D-3L | 0.71 | 0.66 – 0.76 |
EQ-5D VAS | 0.68 | 0.63 – 0.74 |
SF-6D | 0.81 | 0.76 – 0.85 |
SF-12 new algorithm | 0.80 | 0.76 – 0.85 |