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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.06.2018 | Retinal Disorders

RETRACTED ARTICLE: A comparison of risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese patients

verfasst von: Xiao-Li Chen, Qin-Rui Hu, Yu-Jing Bai, Yu Deng, Hai-Wei Wang, Shan Liu, Yin-Lin Wang, Yan-Kun Yue

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 8/2018

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Abstract

Purpose

Neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) are important vision-threatening diseases worldwide. For effective treatment, the risk factors for the diseases merit investigation. This study aimed to compare the risk factors for nAMD vs. PCV in Chinese patients.

Methods

A total of 946 participants were recruited in this case-control study, including 281 patients with nAMD, 306 patients with PCV, and 359 controls. All participants underwent comprehensive ophthalmic examinations. Information on risk factors were collected by questionnaire. Multivariate logistic regression analyses were performed to investigate the difference in risk factors between nAMD and PCV. In a subgroup of subjects, serum lipid data were obtained and analyzed.

Results

Risk factors for nAMD included older age (OR 1.03, P = 0.001), male gender (OR 1.55, P = 0.020), asthma (OR 2.50, P = 0.028), smoking (OR 1.92, P = 0.001), and family history (OR 6.82, P = 0.001), while smoking (OR 1.67, P = 0.013) was the only risk factor for PCV. Compared to patients with PCV, patients with nAMD were more likely to be older and suffer from hyperlipidemia, coronary artery disease, rheumatism, and tumor. Interestingly, higher levels of high-density lipoprotein were positively associated with PCV in the subgroup analysis (OR 7.74, P = 0.011). Besides, results were quite different between the combination of patients with nAMD and PCV and patients with nAMD or PCV alone.

Conclusions

The risk factors for nAMD and PCV is varying with the exception of smoking. Our findings suggest that different strategies might be applied in the clinical management and scientific research on nAMD and PCV.

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Titel: RETRACTED ARTICLE: A comparison of risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese patients
verfasst von: Xiao-Li Chen
Qin-Rui Hu
Yu-Jing Bai
Yu Deng
Hai-Wei Wang
Shan Liu
Yin-Lin Wang
Yan-Kun Yue
Publikationsdatum: 01.06.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 8/2018
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-018-4020-y

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RETRACTED ARTICLE: A comparison of risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese patients