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Erschienen in: Journal of Gastrointestinal Cancer 4/2017

22.08.2017 | Review Article

A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer

verfasst von: Atousa Haghi, Haniye Azimi, Roja Rahimi

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 4/2017

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Abstract

Objective

Gastric cancer is one of the most common causes of cancer-related death worldwide. Medicinal plants are one of the main sources for discovery of new pharmacological agents especially for treatment of cancers. The aim of the present study is to review pharmacotherapeutic aspects of three mostly studied phytochemicals including curcumin, quercetin, and allicin for management of gastric cancer.

Methods

Scopus, PubMed, Web of Science, and Google Scholar were searched for the effects of curcumin, quercetin, allicin, and their analogs in gastric cancer. Data were collected up to November 2015. The search terms were “curcumin,” “quercetin,” “allicin,” and “gastric cancer” or “cancer.”

Results

Curcumin demonstrated anti-angiogenic, anti-proliferative, anti-metastatic, pro-apoptotic, and anti-helicobacter activities. Quercetin inhibited cell growth and induced apoptosis, necrosis, and autophagy as well as anti-Helicobacter activity. Allicin showed apoptotic and anti-Helicobacter properties. All three natural compounds had low bioavailability.

Conclusions

Although preclinical studies demonstrated the activity of curcumin, quercetin, and allicin in gastric cancer, clinical trials are needed to confirm their effectiveness. Applying their possible synergistic action and suitable drug delivery system in clinical studies can be also an attractive approach with the purpose of finding new extremely efficient anti-gastric cancer agents.

Mini-Abstract

Curcumin, quercetin, and allicin seem to be good candidates for management of gastric cancer through their pro-apoptotic, anti-proliferative, and anti-helicobacter activities.
Literatur
2.
Zurück zum Zitat McLean MH, El-Omar EM. Genetics of gastric cancer. Nat Rev Gastroenterol Hepatol. 2014; McLean MH, El-Omar EM. Genetics of gastric cancer. Nat Rev Gastroenterol Hepatol. 2014;
3.
Zurück zum Zitat Romano M, Ricci V, Zarrilli R. Mechanisms of disease: Helicobacter pylori-related gastric carcinogenesis—implications for chemoprevention. Nat Clin Pract Gastroenterol Hepatol. 2006;3:622–32.CrossRefPubMed Romano M, Ricci V, Zarrilli R. Mechanisms of disease: Helicobacter pylori-related gastric carcinogenesis—implications for chemoprevention. Nat Clin Pract Gastroenterol Hepatol. 2006;3:622–32.CrossRefPubMed
4.
Zurück zum Zitat Peek RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2:28–37.CrossRefPubMed Peek RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2:28–37.CrossRefPubMed
5.
Zurück zum Zitat Tsai H-F, Hsu P-N. Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology. Cell Mol Immunol. 2010;7:255–9.CrossRefPubMedPubMedCentral Tsai H-F, Hsu P-N. Interplay between Helicobacter pylori and immune cells in immune pathogenesis of gastric inflammation and mucosal pathology. Cell Mol Immunol. 2010;7:255–9.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010;23:713–39.CrossRefPubMedPubMedCentral Wroblewski LE, Peek RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010;23:713–39.CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Crawford HC, Krishna US, Israel DA, et al. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology. 2003;125:1125–36.CrossRefPubMed Crawford HC, Krishna US, Israel DA, et al. Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa. Gastroenterology. 2003;125:1125–36.CrossRefPubMed
8.
Zurück zum Zitat Lee SY, Shin YW, Hahm KB. Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection. J Dig Dis. 2008;9:129–39.CrossRefPubMed Lee SY, Shin YW, Hahm KB. Phytoceuticals: mighty but ignored weapons against Helicobacter pylori infection. J Dig Dis. 2008;9:129–39.CrossRefPubMed
9.
Zurück zum Zitat Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15:195–218.CrossRefPubMed Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15:195–218.CrossRefPubMed
10.
Zurück zum Zitat Boughan PK, Argent RH, Body-Malapel M, et al. Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor critical regulators of β-defensins during Helicobacter pylori infection. J Biol Chem. 2006;281:11637–48.CrossRefPubMed Boughan PK, Argent RH, Body-Malapel M, et al. Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor critical regulators of β-defensins during Helicobacter pylori infection. J Biol Chem. 2006;281:11637–48.CrossRefPubMed
11.
Zurück zum Zitat Yan F, Cao H, Chaturvedi R, et al. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009;136:1297–307. e3.CrossRefPubMedPubMedCentral Yan F, Cao H, Chaturvedi R, et al. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009;136:1297–307. e3.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Wong BC, Zhang L, Ma J-l, et al. Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Gut 2011:gutjnl-2011-300154. Wong BC, Zhang L, Ma J-l, et al. Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Gut 2011:gutjnl-2011-300154.
13.
Zurück zum Zitat Wu C-Y, Wang C-J, Tseng C-C, et al. Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway. World J Gastroenterol. 2005;11:3197.CrossRefPubMedPubMedCentral Wu C-Y, Wang C-J, Tseng C-C, et al. Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway. World J Gastroenterol. 2005;11:3197.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Keates S, Keates AC, Katchar K, et al. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis. 2007;196:95–103.CrossRefPubMed Keates S, Keates AC, Katchar K, et al. Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis. 2007;196:95–103.CrossRefPubMed
15.
Zurück zum Zitat Li J, Shen L, Lu F-r, et al. Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway. Acta Pharmacol Sin. 2012;33:242–9.CrossRefPubMedPubMedCentral Li J, Shen L, Lu F-r, et al. Plumbagin inhibits cell growth and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway. Acta Pharmacol Sin. 2012;33:242–9.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Yu L-L, Wu J-G, Dai N, et al. Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor. Oncol Rep. 2011;26:1197.PubMed Yu L-L, Wu J-G, Dai N, et al. Curcumin reverses chemoresistance of human gastric cancer cells by downregulating the NF-κB transcription factor. Oncol Rep. 2011;26:1197.PubMed
17.
Zurück zum Zitat Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett. 2004;215:129–40.CrossRefPubMed Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett. 2004;215:129–40.CrossRefPubMed
18.
Zurück zum Zitat Karin M, Cao Y, Greten FR, et al. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002;2:301–10.CrossRefPubMed Karin M, Cao Y, Greten FR, et al. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2002;2:301–10.CrossRefPubMed
19.
Zurück zum Zitat Ema A, Yamashita K, Sakuramoto S, et al. Lymph node ratio is a critical prognostic predictor in gastric cancer treated with S-1 chemotherapy. Gastric Cancer. 2014;17:67–75.CrossRefPubMed Ema A, Yamashita K, Sakuramoto S, et al. Lymph node ratio is a critical prognostic predictor in gastric cancer treated with S-1 chemotherapy. Gastric Cancer. 2014;17:67–75.CrossRefPubMed
20.
Zurück zum Zitat Sarkar FH, Li Y, Wang Z, et al. Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs. Curr Pharm Des. 2010;16:1801.CrossRefPubMedPubMedCentral Sarkar FH, Li Y, Wang Z, et al. Lesson learned from nature for the development of novel anti-cancer agents: implication of isoflavone, curcumin, and their synthetic analogs. Curr Pharm Des. 2010;16:1801.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Aqil F, Munagala R, Jeyabalan J, et al. Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett. 2013;334:133–41.CrossRefPubMedPubMedCentral Aqil F, Munagala R, Jeyabalan J, et al. Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Lett. 2013;334:133–41.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Koosirirat C, Linpisarn S, Changsom D, et al. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10:815–8.CrossRefPubMed Koosirirat C, Linpisarn S, Changsom D, et al. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10:815–8.CrossRefPubMed
23.
Zurück zum Zitat Peng Y-m, Zheng J-b, Zhou Y-b, et al. Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms. Acta Pharmacol Sin. 2013;34:939–50.CrossRefPubMedPubMedCentral Peng Y-m, Zheng J-b, Zhou Y-b, et al. Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms. Acta Pharmacol Sin. 2013;34:939–50.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm. 2010;343:489–99.CrossRef Shehzad A, Wahid F, Lee YS. Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials. Arch Pharm. 2010;343:489–99.CrossRef
25.
Zurück zum Zitat Duvoix A, Blasius R, Delhalle S, et al. Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 2005;223:181–90.CrossRefPubMed Duvoix A, Blasius R, Delhalle S, et al. Chemopreventive and therapeutic effects of curcumin. Cancer Lett. 2005;223:181–90.CrossRefPubMed
26.
Zurück zum Zitat Kunnumakkara AB, Guha S, Krishnan S, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-κB–regulated gene products. Cancer Res. 2007;67:3853–61.CrossRefPubMed Kunnumakkara AB, Guha S, Krishnan S, et al. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-κB–regulated gene products. Cancer Res. 2007;67:3853–61.CrossRefPubMed
27.
Zurück zum Zitat Foryst-Ludwig A, Neumann M, Schneider-Brachert W, et al. Curcumin blocks NF-κB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun. 2004;316:1065–72.CrossRefPubMed Foryst-Ludwig A, Neumann M, Schneider-Brachert W, et al. Curcumin blocks NF-κB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun. 2004;316:1065–72.CrossRefPubMed
28.
Zurück zum Zitat Woo J-H, Kim Y-H, Choi Y-J, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. 2003;24:1199–208.CrossRefPubMed Woo J-H, Kim Y-H, Choi Y-J, et al. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis. 2003;24:1199–208.CrossRefPubMed
29.
Zurück zum Zitat Shehzad A, Khan S, Shehzad O, et al. Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs of Today. 2010;46:523.CrossRefPubMed Shehzad A, Khan S, Shehzad O, et al. Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs of Today. 2010;46:523.CrossRefPubMed
30.
Zurück zum Zitat Kuttan G, Kumar KBH, Guruvayoorappan C, et al. Antitumor, anti-invasion, and antimetastatic effects of curcumin. The molecular targets and therapeutic uses of curcumin in health and disease. Springer; 2007. p. 173–84. Kuttan G, Kumar KBH, Guruvayoorappan C, et al. Antitumor, anti-invasion, and antimetastatic effects of curcumin. The molecular targets and therapeutic uses of curcumin in health and disease. Springer; 2007. p. 173–84.
31.
Zurück zum Zitat Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006;136:716S–25S.PubMed Amagase H. Clarifying the real bioactive constituents of garlic. J Nutr. 2006;136:716S–25S.PubMed
32.
Zurück zum Zitat Xue X, Yu J-L, Sun D-Q, et al. Curcumin induces apoptosis in SGC-7901 gastric adenocarcinoma cells via regulation of mitochondrial signaling pathways. Asian Pac J Cancer Prev. 2014;15:3987–92.CrossRefPubMed Xue X, Yu J-L, Sun D-Q, et al. Curcumin induces apoptosis in SGC-7901 gastric adenocarcinoma cells via regulation of mitochondrial signaling pathways. Asian Pac J Cancer Prev. 2014;15:3987–92.CrossRefPubMed
33.
Zurück zum Zitat Cai X-Z, Wang J, Xiao-Dong L, et al. Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression. Cancer Biol Ther. 2009;8:1360–8.CrossRefPubMed Cai X-Z, Wang J, Xiao-Dong L, et al. Curcumin suppresses proliferation and invasion in human gastric cancer cells by down-regulation of PAK1 activity and cyclin D1 expression. Cancer Biol Ther. 2009;8:1360–8.CrossRefPubMed
34.
Zurück zum Zitat Cao A-L, Tang Q-F, Zhou W-C, et al. Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells. J Asian Nat Prod Res 2014:1–8. Cao A-L, Tang Q-F, Zhou W-C, et al. Ras/ERK signaling pathway is involved in curcumin-induced cell cycle arrest and apoptosis in human gastric carcinoma AGS cells. J Asian Nat Prod Res 2014:1–8.
35.
36.
Zurück zum Zitat Singletary K, Milner J. Diet, autophagy, and cancer: a review. Cancer Epidemiol Biomark Prev. 2008;17:1596–610.CrossRef Singletary K, Milner J. Diet, autophagy, and cancer: a review. Cancer Epidemiol Biomark Prev. 2008;17:1596–610.CrossRef
37.
38.
Zurück zum Zitat Zhang S-F, Wang X-L, Yang X-Q, et al. Autophagy-associated targeting pathways of natural products during cancer treatment. Asian Pac J Cancer Prev: APJCP. 2014;15:10557.CrossRefPubMed Zhang S-F, Wang X-L, Yang X-Q, et al. Autophagy-associated targeting pathways of natural products during cancer treatment. Asian Pac J Cancer Prev: APJCP. 2014;15:10557.CrossRefPubMed
39.
Zurück zum Zitat Sintara K, Thong-Ngam D, Patumraj S, et al. Curcumin suppresses gastric NF-κB activation and macromolecular leakage in Helicobacter pylori-infected rats. World J Gastroenterol: WJG. 2010;16:4039.CrossRefPubMedPubMedCentral Sintara K, Thong-Ngam D, Patumraj S, et al. Curcumin suppresses gastric NF-κB activation and macromolecular leakage in Helicobacter pylori-infected rats. World J Gastroenterol: WJG. 2010;16:4039.CrossRefPubMedPubMedCentral
40.
Zurück zum Zitat Shaikh J, Ankola D, Beniwal V, et al. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci. 2009;37:223–30.CrossRefPubMed Shaikh J, Ankola D, Beniwal V, et al. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci. 2009;37:223–30.CrossRefPubMed
41.
Zurück zum Zitat Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–18.CrossRefPubMed Anand P, Kunnumakkara AB, Newman RA, et al. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4:807–18.CrossRefPubMed
42.
Zurück zum Zitat Zhang L, Kong Y, Wu D, et al. Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci. 2008;17:1971–8.CrossRefPubMedPubMedCentral Zhang L, Kong Y, Wu D, et al. Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci. 2008;17:1971–8.CrossRefPubMedPubMedCentral
43.
Zurück zum Zitat Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol. 2012;143:383–96.CrossRefPubMed Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol. 2012;143:383–96.CrossRefPubMed
44.
Zurück zum Zitat Chen C, Zhou J, Ji C. Quercetin: a potential drug to reverse multidrug resistance. Life Sci. 2010;87:333–8.CrossRefPubMed Chen C, Zhou J, Ji C. Quercetin: a potential drug to reverse multidrug resistance. Life Sci. 2010;87:333–8.CrossRefPubMed
45.
Zurück zum Zitat Dutta KR, Banerjee S, Mitra A. Medicinal plants of West Midnapore, India: emphasis on phytochemical containment having role on oral cancer. Int J Phytopharmacol. 2012;3:198–208. Dutta KR, Banerjee S, Mitra A. Medicinal plants of West Midnapore, India: emphasis on phytochemical containment having role on oral cancer. Int J Phytopharmacol. 2012;3:198–208.
46.
Zurück zum Zitat Bi Y, Shen C, Li C, et al. Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells. Tumor Biol. 2015:1–12. Bi Y, Shen C, Li C, et al. Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells. Tumor Biol. 2015:1–12.
47.
Zurück zum Zitat Jeong JH, An JY, Kwon YT, et al. Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem. 2009;106:73–82.CrossRefPubMedPubMedCentral Jeong JH, An JY, Kwon YT, et al. Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. J Cell Biochem. 2009;106:73–82.CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Hu X-T, Ding C, Zhou N, et al. Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo. Eur J Pharmacol. 2015; Hu X-T, Ding C, Zhou N, et al. Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo. Eur J Pharmacol. 2015;
49.
Zurück zum Zitat Bishayee K, Ghosh S, Mukherjee A, et al. Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction. Cell Prolif. 2013;46:153–63.CrossRefPubMed Bishayee K, Ghosh S, Mukherjee A, et al. Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction. Cell Prolif. 2013;46:153–63.CrossRefPubMed
50.
Zurück zum Zitat Borska S, Chmielewska M, Wysocka T, et al. In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR. Food Chem Toxicol. 2012;50:3375–83.CrossRefPubMed Borska S, Chmielewska M, Wysocka T, et al. In vitro effect of quercetin on human gastric carcinoma: targeting cancer cells death and MDR. Food Chem Toxicol. 2012;50:3375–83.CrossRefPubMed
51.
Zurück zum Zitat Gibellini L, Pinti M, Nasi M, et al. Quercetin and cancer chemoprevention. Evidence-based complementary and alternative medicine 2011;2011. Gibellini L, Pinti M, Nasi M, et al. Quercetin and cancer chemoprevention. Evidence-based complementary and alternative medicine 2011;2011.
52.
Zurück zum Zitat Ekström A, Serafini M, Nyren O, et al. Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden. Ann Oncol. 2011;22:438–43.CrossRefPubMed Ekström A, Serafini M, Nyren O, et al. Dietary quercetin intake and risk of gastric cancer: results from a population-based study in Sweden. Ann Oncol. 2011;22:438–43.CrossRefPubMed
53.
Zurück zum Zitat Nguyen T, Tran E, Nguyen T, et al. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis. 2004;25:647–59.CrossRefPubMed Nguyen T, Tran E, Nguyen T, et al. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis. 2004;25:647–59.CrossRefPubMed
54.
Zurück zum Zitat Rivera AR, Castillo-Pichardo L, Gerena Y, et al. Anti-breast cancer potential of quercetin via the Akt/AMPK/mammalian target of rapamycin (mTOR) signaling cascade. PLoS One. 2016;11:e0157251.CrossRef Rivera AR, Castillo-Pichardo L, Gerena Y, et al. Anti-breast cancer potential of quercetin via the Akt/AMPK/mammalian target of rapamycin (mTOR) signaling cascade. PLoS One. 2016;11:e0157251.CrossRef
55.
Zurück zum Zitat Ranelletti FO, Ricci R, Larocca LM, et al. Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors. Int J Cancer. 1992;50:486–92.CrossRefPubMed Ranelletti FO, Ricci R, Larocca LM, et al. Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors. Int J Cancer. 1992;50:486–92.CrossRefPubMed
56.
Zurück zum Zitat Shen X, Si Y, Wang Z, et al. Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling. Int J Mol Med. 2016; Shen X, Si Y, Wang Z, et al. Quercetin inhibits the growth of human gastric cancer stem cells by inducing mitochondrial-dependent apoptosis through the inhibition of PI3K/Akt signaling. Int J Mol Med. 2016;
57.
Zurück zum Zitat Wang P, Zhang K, Zhang Q, et al. Effects of quercetin on the apoptosis of the human gastric carcinoma cells. Toxicol in Vitro. 2012;26:221–8.CrossRefPubMed Wang P, Zhang K, Zhang Q, et al. Effects of quercetin on the apoptosis of the human gastric carcinoma cells. Toxicol in Vitro. 2012;26:221–8.CrossRefPubMed
58.
Zurück zum Zitat González-Segovia R, Quintanar JL, Salinas E, et al. Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig. J Gastroenterol. 2008;43:441–7.CrossRefPubMed González-Segovia R, Quintanar JL, Salinas E, et al. Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig. J Gastroenterol. 2008;43:441–7.CrossRefPubMed
59.
Zurück zum Zitat Psahoulia FH, Moumtzi S, Roberts ML, et al. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis. 2007;28:1021–31.CrossRefPubMed Psahoulia FH, Moumtzi S, Roberts ML, et al. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis. 2007;28:1021–31.CrossRefPubMed
60.
Zurück zum Zitat Wang K, Liu R, Li J, et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR-and hypoxia-induced factor 1α-mediated signaling. Autophagy. 2011;7:966–78.CrossRefPubMed Wang K, Liu R, Li J, et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR-and hypoxia-induced factor 1α-mediated signaling. Autophagy. 2011;7:966–78.CrossRefPubMed
61.
Zurück zum Zitat Wiczkowski W, Romaszko J, Bucinski A, et al. Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides. J Nutr. 2008;138:885–8.PubMed Wiczkowski W, Romaszko J, Bucinski A, et al. Quercetin from shallots (Allium cepa L. var. aggregatum) is more bioavailable than its glucosides. J Nutr. 2008;138:885–8.PubMed
62.
Zurück zum Zitat Chakraborty S, Stalin S, Das N, et al. The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. Biomaterials. 2012;33:2991–3001.CrossRefPubMed Chakraborty S, Stalin S, Das N, et al. The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. Biomaterials. 2012;33:2991–3001.CrossRefPubMed
63.
Zurück zum Zitat Bat-Chen W, Golan T, Peri I, et al. Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. Nutr Cancer. 2010;62:947–57.CrossRefPubMed Bat-Chen W, Golan T, Peri I, et al. Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2. Nutr Cancer. 2010;62:947–57.CrossRefPubMed
64.
Zurück zum Zitat Borlinghaus J, Albrecht F, Gruhlke MC, et al. Allicin: chemistry and biological properties. Molecules. 2014;19:12591–618.CrossRefPubMed Borlinghaus J, Albrecht F, Gruhlke MC, et al. Allicin: chemistry and biological properties. Molecules. 2014;19:12591–618.CrossRefPubMed
65.
Zurück zum Zitat Zhang Z-m, Zhong N, Gao H-q, et al. Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice. Chin Med J-Beijing-Engl Ed. 2006;119:422. Zhang Z-m, Zhong N, Gao H-q, et al. Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice. Chin Med J-Beijing-Engl Ed. 2006;119:422.
66.
Zurück zum Zitat Cha JH, Choi YJ, Cha SH, et al. Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol Rep. 2012;28:41–8.PubMed Cha JH, Choi YJ, Cha SH, et al. Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway. Oncol Rep. 2012;28:41–8.PubMed
67.
Zurück zum Zitat Park B, Kim K, Rhee D-K, et al. The apoptotic effect of allicin in MCF-7 human breast cancer cells: role for ATF3. The FASEB J. 2012;2012 Park B, Kim K, Rhee D-K, et al. The apoptotic effect of allicin in MCF-7 human breast cancer cells: role for ATF3. The FASEB J. 2012;2012
68.
Zurück zum Zitat Park S-Y, Cho S-J, H-c K, et al. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett. 2005;224:123–32.CrossRefPubMed Park S-Y, Cho S-J, H-c K, et al. Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett. 2005;224:123–32.CrossRefPubMed
69.
Zurück zum Zitat Tao M, Gao L, Pan J, et al. Study on the inhibitory effect of allicin on human gastric cancer cell line sgc-7901 and its mechanism. Afr J Tradit Complement Altern Med. 2013;11:176–9.PubMedPubMedCentral Tao M, Gao L, Pan J, et al. Study on the inhibitory effect of allicin on human gastric cancer cell line sgc-7901 and its mechanism. Afr J Tradit Complement Altern Med. 2013;11:176–9.PubMedPubMedCentral
70.
Zurück zum Zitat Yang JY, Della-Fera MA, Nelson-Dooley C, et al. Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes. Obesity. 2006;14:388–97.CrossRefPubMed Yang JY, Della-Fera MA, Nelson-Dooley C, et al. Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes. Obesity. 2006;14:388–97.CrossRefPubMed
71.
Zurück zum Zitat Chu Y-L, Ho C-T, Chung J-G, et al. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. J Agric Food Chem. 2012;60:8363–71.CrossRefPubMed Chu Y-L, Ho C-T, Chung J-G, et al. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. J Agric Food Chem. 2012;60:8363–71.CrossRefPubMed
72.
Zurück zum Zitat Sun L, Wang X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J Gastroenterol. 2003;9:1930–4.CrossRefPubMedPubMedCentral Sun L, Wang X. Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J Gastroenterol. 2003;9:1930–4.CrossRefPubMedPubMedCentral
73.
Zurück zum Zitat Sivam GP. Protection against Helicobacter pylori and other bacterial infections by garlic. J Nutr. 2001;131:1106S–8S.PubMed Sivam GP. Protection against Helicobacter pylori and other bacterial infections by garlic. J Nutr. 2001;131:1106S–8S.PubMed
74.
Zurück zum Zitat O'Gara EA, Hill DJ, Maslin DJ. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Appl Environ Microbiol. 2000;66:2269–73.CrossRefPubMedPubMedCentral O'Gara EA, Hill DJ, Maslin DJ. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Appl Environ Microbiol. 2000;66:2269–73.CrossRefPubMedPubMedCentral
75.
Zurück zum Zitat Takeuchi H, Trang VT, Morimoto N, et al. Natural products and food components with anti-Helicobacter pylori activities. World J Gastroenterol: WJG. 2014;20:8971.PubMedPubMedCentral Takeuchi H, Trang VT, Morimoto N, et al. Natural products and food components with anti-Helicobacter pylori activities. World J Gastroenterol: WJG. 2014;20:8971.PubMedPubMedCentral
76.
Zurück zum Zitat Nicastro HL, Ross SA, Milner JA. Garlic and onions: their cancer prevention properties. Cancer Prev Res 2015:canprevres. 0172.2014. Nicastro HL, Ross SA, Milner JA. Garlic and onions: their cancer prevention properties. Cancer Prev Res 2015:canprevres. 0172.2014.
77.
Zurück zum Zitat Vazquez-Prieto MA, Miatello RM. Organosulfur compounds and cardiovascular disease. Mol Asp Med. 2010;31:540–5.CrossRef Vazquez-Prieto MA, Miatello RM. Organosulfur compounds and cardiovascular disease. Mol Asp Med. 2010;31:540–5.CrossRef
78.
Zurück zum Zitat Alpers DH. Garlic and its potential for prevention of colorectal cancer and other conditions. Curr Opin Gastroenterol. 2009;25:116–21.CrossRefPubMed Alpers DH. Garlic and its potential for prevention of colorectal cancer and other conditions. Curr Opin Gastroenterol. 2009;25:116–21.CrossRefPubMed
79.
Zurück zum Zitat Iciek M, Kwiecień I, Włodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ Mol Mutagen. 2009;50:247–65.CrossRefPubMed Iciek M, Kwiecień I, Włodek L. Biological properties of garlic and garlic-derived organosulfur compounds. Environ Mol Mutagen. 2009;50:247–65.CrossRefPubMed
80.
Zurück zum Zitat Lu Q, Lu P-M, Piao J-H, et al. Preparation and physicochemical characteristics of an allicin nanoliposome and its release behavior. LWT-Food Sci Technol. 2014;57:686–95.CrossRef Lu Q, Lu P-M, Piao J-H, et al. Preparation and physicochemical characteristics of an allicin nanoliposome and its release behavior. LWT-Food Sci Technol. 2014;57:686–95.CrossRef
81.
82.
Zurück zum Zitat Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008;269:199–225.CrossRefPubMed Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008;269:199–225.CrossRefPubMed
83.
Zurück zum Zitat Dolcet X, Llobet D, Pallares J, et al. NF-kB in development and progression of human cancer. Virchows Arch. 2005;446:475–82.CrossRefPubMed Dolcet X, Llobet D, Pallares J, et al. NF-kB in development and progression of human cancer. Virchows Arch. 2005;446:475–82.CrossRefPubMed
84.
Zurück zum Zitat Moon J-H, Eo SK, Lee JH, et al. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375–81.CrossRefPubMed Moon J-H, Eo SK, Lee JH, et al. Quercetin-induced autophagy flux enhances TRAIL-mediated tumor cell death. Oncol Rep. 2015;34:375–81.CrossRefPubMed
85.
Zurück zum Zitat Lawson LD, Wang ZJ. Low allicin release from garlic supplements: a major problem due to the sensitivities of alliinase activity. J Agric Food Chem. 2001;49:2592–9.CrossRefPubMed Lawson LD, Wang ZJ. Low allicin release from garlic supplements: a major problem due to the sensitivities of alliinase activity. J Agric Food Chem. 2001;49:2592–9.CrossRefPubMed
Metadaten
Titel
A Comprehensive Review on Pharmacotherapeutics of Three Phytochemicals, Curcumin, Quercetin, and Allicin, in the Treatment of Gastric Cancer
verfasst von
Atousa Haghi
Haniye Azimi
Roja Rahimi
Publikationsdatum
22.08.2017
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Cancer / Ausgabe 4/2017
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI
https://doi.org/10.1007/s12029-017-9997-7

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