nach oben

Indian Journal of Otolaryngology and Head & Neck Surgery

Erschienen in:

27.07.2018 | Original Article

A Comprehensive Study of Oxidative Stress in Tinnitus Patients

verfasst von: Mustafa Celik, İsmail Koyuncu

Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery | Ausgabe 4/2018

Einloggen, um Zugang zu erhalten

Abstract

Oxidative stress is considered to be one of the molecular changes that are the underlying causes of tinnitus. The aim of this study was to investigate the dynamic thiol/disulphide homeostasis as a new oxidative stress parameter in tinnitus patients as well as to investigate the lipid hydroperoxide (LOOH), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) parameters and compare the results with the results of the healthy control group. A prospective controlled trial was performed on tinnitus patients in Harran University hospital. A total of 70 subjects, including 35 tinnitus patients and 35 healthy individuals participated in this study. Their total thiol, native thiol levels and LOOH, TAS, TOS levels were measured in plasma of all tinnitus patients and healthy volunteers participants. TOS and OSI levels were significantly increased, and TAS levels were significantly lower in the patient groups compared with the control group (p < 0.01). Native thiol levels and Native thiol/total thiol ratios were significantly lower in the tinnitus group compared to the control group (p < 0.01). Disulphide level and disulphide/native thiol and disulphide/total thiol ratios were significantly higher in the patients (p < 0.01). Also, LOOH ratios were significantly higher in the tinnitus group (p < 0.01). The results of this study reveal that in tinnitus cases, the oxidative stress and antioxidant enzyme imbalance were more significant than in healthy control group. The nature of the relationship between oxidative stress and tinnitus should be clarified with larger studies.

Bauer CA (2015) Tinnitus and hyperacusis. In: Flint FW, Haughey BH, Lund VJ, Niparko JK, Richardson MA (eds) Cummings otolaryngology head & neck surgery, 6th edn. Saunders Elsevier, Philadelphia, pp 2336–2344

Zöger S, Svedlund J, Holgers KM (2001) Psychiatric disorders in tinnitus patients without severe hearing impairment: 24 month follow-up of patients at an audiological clinic. Audiology 40:133–140CrossRef

Nemholt S et al (2015) Prevalence of tinnitus and/or hyperacusis in children and adolescents: study protocol for a systematic review. BMJ Open 5:e006649. https://doi.org/10.1136/bmjopen-2014-006649 CrossRefPubMedPubMedCentral

Brackmann DE, Shelton C, Arriaga MA (1994) Otologic surgery, 1st edn. WB Saunders Comp, Philadelphia, pp 153–162

Kraft JR (1995) Hyperinsulinemia: the common denominator of subjective idiopathic tinnitus and other idiopathic central and peripheral neurootologic disorders. Int Tinnitus J 1:46–53PubMed

Bartels H, Middel BL, van der Laan BF, Staal MJ, Albers FW (2008) The additive effect of co-occurring anxiety and depression on health status, quality of life and coping strategies in help-seeking tinnitus sufferers. Ear Hear 29:947–956. https://doi.org/10.1097/AUD.0b013e3181888f83 CrossRefPubMed

Dobie RA (2003) Depression and tinnitus. Otolaryngol Clin North Am 36:383–388. https://doi.org/10.1016/S0030-6665(02)00168-8 CrossRefPubMed

Calabrese V, Cornelius C, Maiolino L, Luca M, Chiaramonte R, Toscano MA et al (2010) Oxidative stress, redox homeostasis and cellular stress response in Ménière’s disease: role of vitagenes. Neurochem Res 35:2208–2217. https://doi.org/10.1007/s11064-010-0304-2 CrossRefPubMed

Terao K, Cureoglu S, Schachern PA, Morita N, Nomiya S, Deroee AF et al (2011) Cochlear changes in presbycusis with tinnitus. Am J Otolaryngol 32:215–220. https://doi.org/10.1016/j.amjoto.2010.02.001 CrossRefPubMed

10.

Goswami B, Tayal D, Gupta N, Mallika V (2009) Paraoxonase: a multifaceted biomolecule. Clin Chim Acta 410:1–12. https://doi.org/10.1016/j.cca.2009.09.025 CrossRefPubMed

11.

Seidman MD, Ahmad N, Joshi D, Seidman J, Thawani S, Quirk WS (2004) Age-related hearing loss and its association with reactive oxygen species and mitochondrial DNA damage. Acta Otolaryngol Suppl 552:16–24CrossRef

12.

Baysal E, Taysi S, Aksoy N, Uyar M, Çelenk F, Karatas ZA et al (2012) Serum paraoxonase, arylesterase activity and oxidative status in patients with obstructive sleep apnea syndrome (OSAS). Eur Rev Med Pharmacol 16(6):770–774

13.

Koç Sema, Akyüz Servet, Somuk Battal Tahsin, Soyalic Harun, Yılmaz Beyhan, Taskin Abdullah, Bilinc Hasan, Aksoy Nurten (2016) Paraoxonase activity and oxidative status in patients with tinnitus. J Audiol Otol 20(1):17–21. https://doi.org/10.7874/jao.2016.20.1.17 CrossRefPubMedPubMedCentral

14.

Erel O, Neselioglu S (2014) A novel and automated assay for thiol/disulphide homeostasis. Clin Biochem 47(18):326–332. https://doi.org/10.1016/j.clinbiochem.2014.09.026 CrossRefPubMed

15.

Erel O (2004) A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 37:112–119. https://doi.org/10.1016/j.clinbiochem.2003.10.014 CrossRefPubMed

16.

Nourooz-Zadeh J (1999) Ferrous ion oxidation in presence of xylenol orange for detection of lipid hydroperoxides in plasma. Methods Enzymol 300:58–62. https://doi.org/10.1016/S0076-6879(99)00113-5 CrossRefPubMed

17.

Erel O (1998) Automated measurement of serum ferroxidase activity. Clin Chem 44(11):2313–2319PubMed

18.

Choi CH (2012) Mechanisms and treatment of blast induced hearing loss. Korean J Audiol 16:103–107. https://doi.org/10.7874/kja.2012.16.3.103 CrossRefPubMedPubMedCentral

19.

Doğruer ZN, Unal M, Eskandari G, Pata YS, Akbaş Y, Cevik T et al (2004) Malondialdehyde and antioxidant enzymes in children with obstructive adenotonsillar hypertrophy. Clin Biochem 37:718–721. https://doi.org/10.1016/j.clinbiochem.2004.01.004 CrossRefPubMed

20.

Gilles A, Ihtijarevic B, Wouters K, Van de Heyning P (2014) Using prophylactic antioxidants to prevent noise-induced hearing damage in young adults: a protocol for a double-blind, randomized controlled trial. Trials 5:15–110. https://doi.org/10.1186/1745-6215-15-110-15:110 CrossRef

21.

Takumida M, Anniko M, Popa R, Zhang DM (2001) Pharmacological models for inner ear therapy with emphasis on nitric oxide. Acta Otolaryngol 121:16–20CrossRef

22.

Sataloff RT, Bittermann T, Marks L, Lurie D, Hawkshaw M (2010) The effects of glutathione enhancement on sensorineural hearing loss. Ear Nose Throat J 89:422–433PubMed

23.

Sugiyama A, Sun J (2014) Immunochemical detection of lipid hydroperoxide- and aldehyde-modified proteins in diseases. In: Kato Y (ed) Lipid hydroperoxide-derived modification of biomolecules. Subcellular biochemistry, vol 77. Springer, Dordrecht, pp 115–125. https://doi.org/10.1007/978-94-007-7920-4_10 CrossRef

24.

Cross CE, Halliwell B, Borish ET et al (1987) Oxygen radicals and human disease. Ann Int Med 107:526–545CrossRef

25.

Porter NA, Mills KA, Caldwell SE (1995) Mechanisms of free radical oxidation of unsaturated lipids. Lipids 30:277–290CrossRef

26.

Halliwell B (1996) Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Rad Res 25:57–74CrossRef

27.

An YH, Jin SY, Yoon SW, Shim HJ (2014) The effects of unilateral tinnitus on auditory temporal resolution: gaps-in-noise performance. Korean J Audiol 18:119–125. https://doi.org/10.7874/kja.2014.18.3.119 CrossRefPubMedPubMedCentral

28.

Park SY, Back SA, Kim HL, Kim DK, Yeo SW, Park SN (2014) Renexin as a rescue regimen for noise-induced hearing loss. Noise Health 16:257–264. https://doi.org/10.4103/1463-1741.140497 CrossRefPubMed

29.

Neri S, Signorelli S, Pulvirenti D, Mauceri B, Cilio D, Bordonaro F et al (2006) Oxidative stress, nitric oxide, endothelial dysfunction and tinnitus. Free Radic Res 40:615–618. https://doi.org/10.1080/10715760600623825 CrossRefPubMed

30.

Nondahl DM, Cruickshanks KJ, Huang GH, Klein BE, Klein R, Nieto FJ et al (2011) Tinnitus and its risk factors in the Beaver Dam offspring study. Int J Audiol 50:313–320. https://doi.org/10.3109/14992027.2010.551220 CrossRefPubMedPubMedCentral

31.

Levine RA (2013) Tinnitus: diagnostic approach leading to treatment. Semin Neurol 33:256–269. https://doi.org/10.1055/s-0033-1354603 CrossRefPubMed

32.

Savastano M, Brescia G, Marioni G (2007) Antioxidant therapy in idiopathic tinnitus: preliminary outcomes. Arch Med Res 38:456–459. https://doi.org/10.1016/j.arcmed.2006.12.004 CrossRefPubMed

33.

Gopal KV, Thomas BP, Mao D, Lu H (2015) Efficacy of carnitine in treatment of tinnitus: evidence from audiological and MRI measures-a case study. J Am Acad Audiol 26:311–324. https://doi.org/10.3766/jaaa.26.3.10 CrossRefPubMed

34.

Polanski JF, Soares AD, de Mendonça Cruz OL (2016) Antioxidant therapy in the elderly with tinnitus. Braz J Otorhinolaryngol 82(3):269–274. https://doi.org/10.1016/j.bjorl.2015.04.016 CrossRefPubMed

Titel: A Comprehensive Study of Oxidative Stress in Tinnitus Patients
verfasst von: Mustafa Celik
İsmail Koyuncu
Publikationsdatum: 27.07.2018
Verlag: Springer India
Erschienen in: Indian Journal of Otolaryngology and Head & Neck Surgery / Ausgabe 4/2018
Print ISSN: 2231-3796
Elektronische ISSN: 0973-7707
DOI: https://doi.org/10.1007/s12070-018-1464-7

Neu im Fachgebiet HNO

15.04.2024 | Hörsturz | Nachrichten

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Springer Medizin

A Comprehensive Study of Oxidative Stress in Tinnitus Patients

Abstract

Neu im Fachgebiet HNO

Bilateraler Hörsturz hat eine schlechte Prognose

RRP: Adjuvante HPV-Impfung in jedem Alter empfehlenswert

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Hundehalter mit Luftnot: War es die Katzenminze?

Update HNO

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2018

A Revisit to High Jugular Bulb: A Newer Clinical Grading

New Cartilage Slicer for Slicing Techniques in Tympanoplasty: Design and Applications

Post Temporal Bone Fracture Facial Paralysis: Strategies in Decision Making and Analysis of Efficacy of Surgical Treatment

Long Term Oncological Results of Transoral Laser Microsurgery for Early and Moderately Advanced Glottic Carcinoma in Primary and Salvage Settings

The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa

Mini Inferior Turbinoplasty-Tunneling Technique

Neu im Fachgebiet HNO

Bilateraler Hörsturz hat eine schlechte Prognose

RRP: Adjuvante HPV-Impfung in jedem Alter empfehlenswert

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Hundehalter mit Luftnot: War es die Katzenminze?

Update HNO