Background
Methods
Patient enrollment
Definition of the post-operative pneumonia
Data collection and study variables
Variables | Pneumonia | No pneumonia | |||
---|---|---|---|---|---|
(n = 51) | (n = 1105) | ||||
Median(IQR) | Range | Range | Median(IQR) | P Value | |
Age at diagnosis, years | 58 (49~66) | 24–81 | 18–85 | 51 (43~61) | 0.002a |
Gender No. (%) | |||||
Female | 34 (67) | 782 (71) | 0.530b | ||
Male | 17 (33) | 323 (29) | |||
Recurrent | |||||
Yes | 8 (16) | 41 (4) | < 0.001b | ||
No | 43 (84) | 1064 (96) | |||
Tumor localizations | |||||
Skull base | 27 (53) | 394 (36) | 0.003b | ||
Non-skull base c | 24 (47) | 711 (64) | |||
Grade | |||||
I | 41 (80) | 906 (82) | 0.772b | ||
II/III | 10 (20) | 199 (18) | |||
Preoperative Steroids | |||||
Yes | 8 (16) | 96 (9) | 0.125b | ||
No | 43 (84) | 1009 (91) | |||
Preoperative Chest X-ray | |||||
Normal | 28 (55) | 767 (69) | 0.029b | ||
Abnormal | 23 (45) | 338 (31) | |||
Smoking | |||||
Yes | 10 (20) | 132 (12) | 0.103b | ||
No | 41 (80) | 973 (88) | |||
DM | |||||
Yes | 4 (8) | 36 (3) | 0.095b | ||
No | 47 (92) | 1069 (97) | |||
CVD | |||||
Yes | 13 (25) | 111 (10) | < 0.001b | ||
No | 38 (75) | 994 (90) | |||
Blood transfusion | |||||
Yes | 10 (20) | 80 (7) | 0.004b | ||
No | 41 (80) | 1025 (93) | |||
Size (cm) | |||||
< 3 cm | 3 (6) | 167 (15) | 0.006b | ||
3 cm–5 cm | 14 (27) | 439 (40) | |||
≥ 5 cm | 34 (67) | 483 (44) | |||
Postoperative hospital stay, days | 21 (17~29) | 7–229 | 2~20 | 7 (6~9) | < 0.001a |
Variables | Pneumonia (n = 51) | Non-pneumonia (n = 1105) | |||
---|---|---|---|---|---|
Value | Value | ||||
HGB | (< 110/110~150/> 150 g/L) | 3/42/6 | 130(IQR 119~140) | 61/901/143 | 133(IQR 123~143) |
HCT | (< 0.36/0.36~0.47/> 0.47 L/L) | 6/43/2 | 0.41(IQR 0.37~0.43) | 86/960/59 | 0.41(IQR 0.38~0.44) |
MCV | (< 80/≥80 fL) | 3/48 | 90.7(IQR 88~94.7) | 69/1036 | 91.3(IQR 88.3~94.2) |
MCH | (< 27/27~32/> 32 pg) | 6/41/4 | 29.6(IQR 28.3~30.6) | 106/906/93 | 29.9(IQR 28.8~30.9) |
MCHC | (< 310/≥310 g/L) | 9/42 | 324(IQR 315~332) | 96/1009 | 326(IQR 319~333) |
RDW-SD | (≤54/> 54 fL) | 46/5 | 46.2(IQR 43.3~49.4) | 1095/10 | 45.1(IQR 42.9~47.25) |
RDW-CV | (≤14.5/> 14.5%) | 37/14 | 14(IQR 13.2~14.9) | 929/176 | 13.6(IQR 13.1~14.2) |
Platelet Counts | (< 100/≥100 × 109/L) | 6/45 | 174(IQR 137~214) | 60/1045 | 174(IQR 139~217.5) |
WBC | (< 4/4~10/ > 10 × 109/L) | 4/38/9 | 6.28(IQR 5.44~8) | 76/953/76 | 6(IQR 5.01~7.295) |
Neutrophils | (< 2.0/2.0~7.5/> 7.5 × 109/L) | 1/42/8 | 4.17(IQR 3.27~6.11) | 35/991/79 | 3.75(IQR 2.97~4.995) |
Lymphocytes | (< 3.5/≥3.5 × 109/L) | 2/49 | 1.59(IQR 1.12~1.79) | 1095/10 | 1.62(IQR 1.25~2) |
Monocytes | (< 0.12/≥0.12 × 109/L) | 7/44 | 0.3(IQR 0.2~0.4) | 59/1046 | 0.29(IQR 0.22~0.37) |
Albumin | (< 35/≥35 g/L) | 4/47 | 41.9(IQR 39.1~43.8) | 28/1077 | 42.9(IQR 40.5~45.2) |
Globulin | (≤34/> 34 g/L) | 7/44 | 27.5(IQR 25.1~31.7) | 1039/66 | 27.1(IQR 24.4~29.8) |
TG | (≤1.83/> 1.83 mmol/L) | 11/40 | 1.18(IQR 0.84~1.78) | 844/261 | 1.24(IQR 0.905~1.78) |
Cholesterol | (≤5.7/> 5.7 mmol/L) | 43/8 | 4.67(IQR 1.08~5.47) | 942/163 | 4.66(IQR 4.07~5.29) |
HDL | (≤0.9/> 0.9 mmol/L) | 2/49 | 1.33(IQR 1.18~1.55) | 64/1041 | 1.4(IQR 1.17~1.67) |
A/G | (< 1.2/≥1.2) | 8/43 | 1.54(IQR 1.3~1.7) | 56/1049 | 1.58(IQR 1.41~1.77) |
NLR | (< 2.5/2.5~5/> 5) | 19/22/10 | 2.73(IQR 2.1~4.72) | 633/343/129 | 2.27(IQR 1.755~3.24) |
Statistical analysis
Results
Demographic data of 1156 patients with meningioma resection
Pre-operative data of hematological biochemical markers
Univariate and multivariate logistic regression analysis for risk factors for the pop
Variables | Univariate Cox Regression | Multivariate Cox Regression | ||
---|---|---|---|---|
Odds Ratio(95%CI) | P Value | Odds Ratio(95%CI) | P Value | |
Age (< 65-years old) | 2.509 (1.105~3.837) | 0.023 | ||
Gender (Female) | 1.211 (0.667~2.198) | 0.53 | ||
Recurrent (No) | 4.828 (2.134~10.925) | < 0.001 | 7.013 (2.772~17.74) | < 0.001 |
Localizations (Non-skull base) | 2.325 (1.308~4.131) | 0.004 | 2.784 (1.482~5.229) | 0.001 |
Grades (I) | ||||
Grade II | 0.988 (0.455~2.142) | 0.975 | ||
Grade III | 2.210 (0.500~9.774) | 0.296 | ||
Preoperative Steroids (No) | 1.955 (0.894~4.279) | 0.093 | ||
Chest-X Ray (Normal) | 1.900 (0.901~4.006) | 0.092 | ||
Smoking (No) | 1.798 (0.88~3.674) | 0.108 | ||
DM (No) | 2.257 (0.864~7.394) | 0.091 | ||
CVD (No) | 3.064 (1.584~5.925) | 0.001 | 3.692 (1.734~7.862) | 0.001 |
Blood Transfusion (No) | 3.125 (1.509~6.470) | 0.002 | 2.659 (1.180~5.992) | 0.018 |
Size (< 5 cm) | 2.878 (0.886~9.347) | 0.079 | ||
HGB (< 110 g/L) | ||||
110~150 g/L | 0.948 (0.286~3.146) | 0.930 | ||
> 150 g/L | 0.853 (0.207~3.522) | 0.826 | ||
HCT (< 0.36 L/L) | ||||
0.36~0.47 L/L | 0.642 (0.266~1.551) | 0.325 | ||
> 0.47 L/L | 0.486 (0.095~2.490) | 0.387 | ||
MCV(< 80 fl) | 1.066 (0.324~3.508) | 0.917 | ||
MCH (< 27 pg) | ||||
27~32 pg | 0.792 (0.328~1.910) | 0.603 | ||
> 32 pg | 0.745 (0.204~2.720) | 0.656 | ||
MCHC (< 310 g/L) | 0.454 (0.215~0.961) | 0.039 | ||
RDW-SD(≤54 fl) | 11.902 (3.91~36.235) | < 0.001 | 5.267 (1.316~21.078) | 0.019 |
RDW-CV(≤14.5%) | 1.997 (1.158~3.772) | 0.033 | ||
Platelet Count(< 100 × 109/L) | 0.431 (0.177~1.049) | 0.064 | ||
WBC (< 4 × 109/L) | ||||
4~10 × 109/L | 0.758 (0.263~2.179) | 0.607 | ||
> 10 × 109/L | 2.250 (0.664~7.621) | 0.193 | ||
Neutrophils (< 2 × 109/L) | ||||
2~7.5 × 109/L | 1.483 (0.198~11.088) | 0.701 | ||
> 7.5 × 109/L | 3.544 (0.427~29.428) | 0.241 | ||
Lymphocytes (< 3.5 × 109/L) | 4.469 (0.953~20.951) | 0.058 | ||
Monocytes (< 0.12 × 109/L) | 0.355 (0.153~0.821) | 0.015 | ||
Albumin (< 35 g/L) | 0.305 (1.103~0.906) | 0.033 | ||
Globulin (≤34 g/L) | 2.504 (1.086~5.775) | 0.031 | ||
TG (≤1.83 mmol/L) | 0.966 (0.498~1.871) | 0.918 | ||
Cholesterol (≤5.7/mmol/L) | 1.083 (0.500~2.346) | 0.840 | ||
HDL (≤0.9 mmol/L) | 1.333 (0.316~5.618) | 0.696 | ||
A/G (< 1.2) | 0.287 (0.129~0.639) | 0.002 | ||
NLR (< 2.5) | ||||
2.5~5 | 2.137 (1.141~4.003) | 0.018 | 2.081 (1.063~4.067) | 0.033 |
> 5 | 2.583 (1.174~5.684) | 0.018 |