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Erschienen in: International Ophthalmology 3/2018

25.05.2017 | Original Paper

A cross-sectional comparative study on chronic ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series

verfasst von: Loraine L. W. Chow, Alex L. K. Ng, Sharon S. W. Chow, Bonnie N. K. Choy, Kendrick C. Shih, Ian Y. H. Wong, Johnny C. Y. Chan, Jimmy S. M. Lai

Erschienen in: International Ophthalmology | Ausgabe 3/2018

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Abstract

Purpose

To compare the chronic ocular manifestations in Stevens–Johnson syndrome and toxic epidermal necrolysis patients from a 15-year cohort.

Methods

All SJS and TEN patients admitted to our burn intensive care unit between 1999 and 2014 were invited for assessment. Slit-lamp examination was performed, and ocular condition was graded according to the Sotozono scoring System, which depended on the extent of cornea, conjunctiva and lid involvement. Tear osmolarity was also measured.

Results

A total of 18 SJS and 4 TEN cases with an average of 92 and 135 months from disease onset were included. The average age of onset was 46.4 ± 16.6 in SJS and 43.5 ± 19.3 in TEN patients. The LogMAR visual acuity was 0.209 ± 0.591 in SJS and 0.489 ± 0.688 in TEN patients (p = 0.048). The average total Sotozono score was 3.75 ± 7.32 in SJS and 6.88 ± 9.49 in TEN (p = 0.358). Neither the age of onset (p = 0.787), length of follow-up (p = 0.256) nor disease type (SJS vs TEN, p = 0.188) predicted the Sotozono score. There was a statistically significant correlation between Sotozono score and LogMAR VA (r s = 0.437, p = 0.003).

Conclusion

The average total Sotozono score was higher in the TEN group than in the SJS group, but the difference was not statistically significant. Nevertheless, the score correlated with the visual acuity which was statistically worse in the TEN group.
Literatur
1.
Zurück zum Zitat Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J (2016) Stevens–Johnson syndrome/toxic epidermal necrolysis—a comprehensive review and guide to therapy. I. Systemic disease. Ocul Surf 14:2–19CrossRefPubMed Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J (2016) Stevens–Johnson syndrome/toxic epidermal necrolysis—a comprehensive review and guide to therapy. I. Systemic disease. Ocul Surf 14:2–19CrossRefPubMed
2.
Zurück zum Zitat Roujeau JC (1994) The spectrum of Stevens–Johnson syndrome and toxic epidermal necrolysis: a clinical classification. J Invest Dermatol 102:28s–30sCrossRefPubMed Roujeau JC (1994) The spectrum of Stevens–Johnson syndrome and toxic epidermal necrolysis: a clinical classification. J Invest Dermatol 102:28s–30sCrossRefPubMed
3.
Zurück zum Zitat Khalili B, Bahna SL (2006) Pathogenesis and recent therapeutic trends in Stevens–Johnson syndrome and toxic epidermal necrolysis. Ann Allergy Asthma Immunol 97:272–280; quiz 281–273, 320 Khalili B, Bahna SL (2006) Pathogenesis and recent therapeutic trends in Stevens–Johnson syndrome and toxic epidermal necrolysis. Ann Allergy Asthma Immunol 97:272–280; quiz 281–273, 320
4.
Zurück zum Zitat Diphoorn J, Cazzaniga S, Gamba C, Schroeder J, Citterio A, Rivolta AL, Vighi GD, Naldi L (2016) Incidence, causative factors and mortality rates of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in northern Italy: data from the REACT registry. Pharmacoepidemiol Drug Saf 25:196–203CrossRefPubMed Diphoorn J, Cazzaniga S, Gamba C, Schroeder J, Citterio A, Rivolta AL, Vighi GD, Naldi L (2016) Incidence, causative factors and mortality rates of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in northern Italy: data from the REACT registry. Pharmacoepidemiol Drug Saf 25:196–203CrossRefPubMed
5.
Zurück zum Zitat Hsu DY, Brieva J, Silverberg NB, Silverberg JI (2016) Morbidity and mortality of Stevens–Johnson syndrome and toxic epidermal necrolysis in United States adults. J Invest Dermatol 136:1387–1397CrossRefPubMed Hsu DY, Brieva J, Silverberg NB, Silverberg JI (2016) Morbidity and mortality of Stevens–Johnson syndrome and toxic epidermal necrolysis in United States adults. J Invest Dermatol 136:1387–1397CrossRefPubMed
6.
Zurück zum Zitat Lopez-Garcia JS, Rivas Jara L, Garcia-Lozano CI, Conesa E, de Juan IE (2011) Murube del Castillo J: ocular features and histopathologic changes during follow-up of toxic epidermal necrolysis. Ophthalmology 118:265–271CrossRefPubMed Lopez-Garcia JS, Rivas Jara L, Garcia-Lozano CI, Conesa E, de Juan IE (2011) Murube del Castillo J: ocular features and histopathologic changes during follow-up of toxic epidermal necrolysis. Ophthalmology 118:265–271CrossRefPubMed
7.
Zurück zum Zitat Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM (2007) Erythema multiforme, Stevens–Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management. Cornea 26:123–129CrossRefPubMed Chang YS, Huang FC, Tseng SH, Hsu CK, Ho CL, Sheu HM (2007) Erythema multiforme, Stevens–Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management. Cornea 26:123–129CrossRefPubMed
8.
Zurück zum Zitat Correia O, Chosidow O, Saiag P, Bastuji-Garin S, Revuz J, Roujeau JC (1993) Evolving pattern of drug-induced toxic epidermal necrolysis. Dermatology (Basel, Switzerland) 186:32–37 Correia O, Chosidow O, Saiag P, Bastuji-Garin S, Revuz J, Roujeau JC (1993) Evolving pattern of drug-induced toxic epidermal necrolysis. Dermatology (Basel, Switzerland) 186:32–37
9.
Zurück zum Zitat Oplatek A, Brown K, Sen S, Halerz M, Supple K, Gamelli RL (2006) Long-term follow-up of patients treated for toxic epidermal necrolysis. J Burn Care Res 27:26–33CrossRefPubMed Oplatek A, Brown K, Sen S, Halerz M, Supple K, Gamelli RL (2006) Long-term follow-up of patients treated for toxic epidermal necrolysis. J Burn Care Res 27:26–33CrossRefPubMed
10.
Zurück zum Zitat Power WJ, Ghoraishi M, Merayo-Lloves J, Neves RA, Foster CS (1995) Analysis of the acute ophthalmic manifestations of the erythema multiforme/Stevens–Johnson syndrome/toxic epidermal necrolysis disease spectrum. Ophthalmology 102:1669–1676CrossRefPubMed Power WJ, Ghoraishi M, Merayo-Lloves J, Neves RA, Foster CS (1995) Analysis of the acute ophthalmic manifestations of the erythema multiforme/Stevens–Johnson syndrome/toxic epidermal necrolysis disease spectrum. Ophthalmology 102:1669–1676CrossRefPubMed
11.
Zurück zum Zitat Revuz J, Penso D, Roujeau JC, Guillaume JC, Payne CR, Wechsler J, Touraine R (1987) Toxic epidermal necrolysis. Clinical findings and prognosis factors in 87 patients. Arch Dermatol 123:1160–1165CrossRefPubMed Revuz J, Penso D, Roujeau JC, Guillaume JC, Payne CR, Wechsler J, Touraine R (1987) Toxic epidermal necrolysis. Clinical findings and prognosis factors in 87 patients. Arch Dermatol 123:1160–1165CrossRefPubMed
12.
Zurück zum Zitat Sotozono C, Ang LP, Koizumi N, Higashihara H, Ueta M, Inatomi T, Yokoi N, Kaido M, Dogru M, Shimazaki J, Tsubota K, Yamada M, Kinoshita S (2007) New grading system for the evaluation of chronic ocular manifestations in patients with Stevens–Johnson syndrome. Ophthalmology 114:1294–1302CrossRefPubMed Sotozono C, Ang LP, Koizumi N, Higashihara H, Ueta M, Inatomi T, Yokoi N, Kaido M, Dogru M, Shimazaki J, Tsubota K, Yamada M, Kinoshita S (2007) New grading system for the evaluation of chronic ocular manifestations in patients with Stevens–Johnson syndrome. Ophthalmology 114:1294–1302CrossRefPubMed
13.
Zurück zum Zitat Van Zyl L, Carrara H, Lecuona K (2014) Prevalence of chronic ocular complications in Stevens–Johnson syndrome and toxic epidermal necrolysis. Middle East Afr J Ophthalmol 21:332–335CrossRefPubMedPubMedCentral Van Zyl L, Carrara H, Lecuona K (2014) Prevalence of chronic ocular complications in Stevens–Johnson syndrome and toxic epidermal necrolysis. Middle East Afr J Ophthalmol 21:332–335CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat De Rojas MV, Dart JK, Saw VP (2007) The natural history of Stevens Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy. Br J Ophthalmol 91:1048–1053CrossRefPubMedPubMedCentral De Rojas MV, Dart JK, Saw VP (2007) The natural history of Stevens Johnson syndrome: patterns of chronic ocular disease and the role of systemic immunosuppressive therapy. Br J Ophthalmol 91:1048–1053CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Williams GP, Tomlins PJ, Denniston AK, Southworth HS, Sreekantham S, Curnow SJ, Rauz S (2013) Elevation of conjunctival epithelial CD45INTCD11b(+)CD16(+)CD14(-) neutrophils in ocular Stevens–Johnson syndrome and toxic epidermal necrolysis. Invest Ophthalmol Vis Sci 54:4578–4585CrossRefPubMedPubMedCentral Williams GP, Tomlins PJ, Denniston AK, Southworth HS, Sreekantham S, Curnow SJ, Rauz S (2013) Elevation of conjunctival epithelial CD45INTCD11b(+)CD16(+)CD14(-) neutrophils in ocular Stevens–Johnson syndrome and toxic epidermal necrolysis. Invest Ophthalmol Vis Sci 54:4578–4585CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Yip LW, Thong BY, Lim J, Tan AW, Wong HB, Handa S, Heng WJ (2007) Ocular manifestations and complications of Stevens–Johnson syndrome and toxic epidermal necrolysis: an Asian series. Allergy 62:527–531CrossRefPubMed Yip LW, Thong BY, Lim J, Tan AW, Wong HB, Handa S, Heng WJ (2007) Ocular manifestations and complications of Stevens–Johnson syndrome and toxic epidermal necrolysis: an Asian series. Allergy 62:527–531CrossRefPubMed
17.
Zurück zum Zitat Chang VS, Chodosh J, Papaliodis GN (2016) Chronic ocular complications of Stevens–Johnson syndrome and toxic epidermal necrolysis: the role of systemic immunomodulatory therapy. Semin Ophthalmol 31:178–187CrossRefPubMed Chang VS, Chodosh J, Papaliodis GN (2016) Chronic ocular complications of Stevens–Johnson syndrome and toxic epidermal necrolysis: the role of systemic immunomodulatory therapy. Semin Ophthalmol 31:178–187CrossRefPubMed
18.
Zurück zum Zitat Morales ME, Purdue GF, Verity SM, Arnoldo BD, Blomquist PH (2010) Ophthalmic manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis and relation to SCORTEN. Am J Ophthalmol 150(505–510):e501 Morales ME, Purdue GF, Verity SM, Arnoldo BD, Blomquist PH (2010) Ophthalmic manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis and relation to SCORTEN. Am J Ophthalmol 150(505–510):e501
19.
Zurück zum Zitat Potvin R, Makari S, Rapuano CJ (2015) Tear film osmolarity and dry eye disease: a review of the literature. Clin ophthalmol (Auckland, NZ) 9:2039–2047 Potvin R, Makari S, Rapuano CJ (2015) Tear film osmolarity and dry eye disease: a review of the literature. Clin ophthalmol (Auckland, NZ) 9:2039–2047
20.
Zurück zum Zitat Lemp MA, Bron AJ, Baudouin C, Benitez Del Castillo JM, Geffen D, Tauber J, Foulks GN, Pepose JS, Sullivan BD (2011) Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 151(792–798):e791 Lemp MA, Bron AJ, Baudouin C, Benitez Del Castillo JM, Geffen D, Tauber J, Foulks GN, Pepose JS, Sullivan BD (2011) Tear osmolarity in the diagnosis and management of dry eye disease. Am J Ophthalmol 151(792–798):e791
21.
Zurück zum Zitat Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Del Castillo JM, O’Brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, van Setten G, Wilson SE, Yiu SC (2006) Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea 25:900–907CrossRefPubMed Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Del Castillo JM, O’Brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, van Setten G, Wilson SE, Yiu SC (2006) Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea 25:900–907CrossRefPubMed
22.
Zurück zum Zitat Gueudry J, Roujeau JC, Binaghi M, Soubrane G, Muraine M (2009) Risk factors for the development of ocular complications of Stevens–Johnson syndrome and toxic epidermal necrolysis. Arch Dermatol 145:157–162PubMed Gueudry J, Roujeau JC, Binaghi M, Soubrane G, Muraine M (2009) Risk factors for the development of ocular complications of Stevens–Johnson syndrome and toxic epidermal necrolysis. Arch Dermatol 145:157–162PubMed
23.
Zurück zum Zitat Biber JM, Skeens HM, Neff KD, Holland EJ (2011) The cincinnati procedure: technique and outcomes of combined living-related conjunctival limbal allografts and keratolimbal allografts in severe ocular surface failure. Cornea 30:765–771CrossRefPubMed Biber JM, Skeens HM, Neff KD, Holland EJ (2011) The cincinnati procedure: technique and outcomes of combined living-related conjunctival limbal allografts and keratolimbal allografts in severe ocular surface failure. Cornea 30:765–771CrossRefPubMed
24.
Zurück zum Zitat Alexander JK, Basak SK, Padilla MD, Yu F, Aldave AJ (2015) International outcomes of the Boston Type I keratoprosthesis in Stevens–Johnson syndrome. Cornea 34:1387–1394CrossRefPubMed Alexander JK, Basak SK, Padilla MD, Yu F, Aldave AJ (2015) International outcomes of the Boston Type I keratoprosthesis in Stevens–Johnson syndrome. Cornea 34:1387–1394CrossRefPubMed
Metadaten
Titel
A cross-sectional comparative study on chronic ocular manifestations of Stevens–Johnson syndrome and toxic epidermal necrolysis in Chinese eyes: a 15-year case series
verfasst von
Loraine L. W. Chow
Alex L. K. Ng
Sharon S. W. Chow
Bonnie N. K. Choy
Kendrick C. Shih
Ian Y. H. Wong
Johnny C. Y. Chan
Jimmy S. M. Lai
Publikationsdatum
25.05.2017
Verlag
Springer Netherlands
Erschienen in
International Ophthalmology / Ausgabe 3/2018
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-017-0576-5

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