Skip to main content
Erschienen in: Journal of Digital Imaging 6/2018

06.07.2018

A Decision-Support Tool for Renal Mass Classification

verfasst von: Gautam Kunapuli, Bino A. Varghese, Priya Ganapathy, Bhushan Desai, Steven Cen, Manju Aron, Inderbir Gill, Vinay Duddalwar

Erschienen in: Journal of Imaging Informatics in Medicine | Ausgabe 6/2018

Einloggen, um Zugang zu erhalten

Abstract

We investigate the viability of statistical relational machine learning algorithms for the task of identifying malignancy of renal masses using radiomics-based imaging features. Features characterizing the texture, signal intensity, and other relevant metrics of the renal mass were extracted from multiphase contrast-enhanced computed tomography images. The recently developed formalism of relational functional gradient boosting (RFGB) was used to learn human-interpretable models for classification. Experimental results demonstrate that RFGB outperforms many standard machine learning approaches as well as the current diagnostic gold standard of visual qualification by radiologists.
Fußnoten
1
https://www.cs.waikato.ac.nz/ml/weka/
 
2
https://starling.utdallas.edu/software/boostsrl/
 
Literatur
2.
Zurück zum Zitat Rendon RA: Active surveillance as the preferred management option for small renal masses. Can Urol Assoc J 4:136–138, 2010CrossRef Rendon RA: Active surveillance as the preferred management option for small renal masses. Can Urol Assoc J 4:136–138, 2010CrossRef
3.
Zurück zum Zitat Adam C. Mues and Jaime Landman: Small renal masses: current concepts regarding the natural history and reflections on the American Urological Association guidelines. Curr Opin Urol 20, 2010. Adam C. Mues and Jaime Landman: Small renal masses: current concepts regarding the natural history and reflections on the American Urological Association guidelines. Curr Opin Urol 20, 2010.
4.
Zurück zum Zitat Heuer R, Gill IS, Guazzoni G, Kirkali Z, Marberger M, Richie JP, de la Rosette JJMCH: A critical analysis of the actual role of minimally invasive surgery and active surveillance for kidney cancer. Eur Urol 57(2):223–232, 2010CrossRef Heuer R, Gill IS, Guazzoni G, Kirkali Z, Marberger M, Richie JP, de la Rosette JJMCH: A critical analysis of the actual role of minimally invasive surgery and active surveillance for kidney cancer. Eur Urol 57(2):223–232, 2010CrossRef
5.
Zurück zum Zitat Xipell JM: The incidence of benign renal nodules (a clinicopathologic study). J Urol 106(4):503–506, 1971CrossRef Xipell JM: The incidence of benign renal nodules (a clinicopathologic study). J Urol 106(4):503–506, 1971CrossRef
6.
Zurück zum Zitat Gill IS, Aron M, Gervais DA, Jewett MAS: Small renal mass. N Engl J Med 362(7):624–634, 2010CrossRef Gill IS, Aron M, Gervais DA, Jewett MAS: Small renal mass. N Engl J Med 362(7):624–634, 2010CrossRef
7.
Zurück zum Zitat Mindrup Steven R, Pierre Jessica S, Laila D, Konety Badrinath R: The prevalence of renal cell carcinoma diagnosed at autopsy. BJU Int 95(1):31–33, 2005CrossRef Mindrup Steven R, Pierre Jessica S, Laila D, Konety Badrinath R: The prevalence of renal cell carcinoma diagnosed at autopsy. BJU Int 95(1):31–33, 2005CrossRef
8.
Zurück zum Zitat Duddalwar V, Zhang X, Hwang D, Cen S, Yap F, Ugwueze C, Abreu A, Aron M, Desai M, Gill I: PD14-07 Differentiation between clear cell renal cell carcinomas and oncocytomas using texture analysis of CT images. J Urol 195(4):e305, 2016CrossRef Duddalwar V, Zhang X, Hwang D, Cen S, Yap F, Ugwueze C, Abreu A, Aron M, Desai M, Gill I: PD14-07 Differentiation between clear cell renal cell carcinomas and oncocytomas using texture analysis of CT images. J Urol 195(4):e305, 2016CrossRef
9.
Zurück zum Zitat Bino Abel Varghese, Darryl Hwang, Steven Cen, Bhushan Desai, Felix Yap, and Vinay Duddalwar: Spectral Analysis of Renal Tumors: Evaluation of a CT Radiomic Technique. Radiol Soc N Am, 2016. Bino Abel Varghese, Darryl Hwang, Steven Cen, Bhushan Desai, Felix Yap, and Vinay Duddalwar: Spectral Analysis of Renal Tumors: Evaluation of a CT Radiomic Technique. Radiol Soc N Am, 2016.
10.
Zurück zum Zitat C. Reddy and C. Aggarwal: Healthcare Data Analytics. Chapman & Hall/CRC Data Mining and Knowledge Discovery Series. CRC Press, 2016. C. Reddy and C. Aggarwal: Healthcare Data Analytics. Chapman & Hall/CRC Data Mining and Knowledge Discovery Series. CRC Press, 2016.
11.
Zurück zum Zitat Miller RA: Medical diagnostic decision support systems—past, present, and future: a threaded bibliography and brief commentary. J Am Med Inform Assoc 1(1):8–27, 1994CrossRef Miller RA: Medical diagnostic decision support systems—past, present, and future: a threaded bibliography and brief commentary. J Am Med Inform Assoc 1(1):8–27, 1994CrossRef
12.
Zurück zum Zitat Wyatt JC, Altman DG: Commentary: Prognostic models: clinically useful or quickly forgotten? Br Med J 311(7019):1539–1541, 1995CrossRef Wyatt JC, Altman DG: Commentary: Prognostic models: clinically useful or quickly forgotten? Br Med J 311(7019):1539–1541, 1995CrossRef
13.
Zurück zum Zitat Bates DW, Kuperman GJ, Wang S, Gandhi T, Kittler A, Volk L, Spurr C, Khorasani R, Tanasijevic M, Middleton B: Ten commandments for effective clinical decision support: making the practice of evidence-based medicine a reality. J Am Med Inform Assoc 10(6):523–530, 2003CrossRef Bates DW, Kuperman GJ, Wang S, Gandhi T, Kittler A, Volk L, Spurr C, Khorasani R, Tanasijevic M, Middleton B: Ten commandments for effective clinical decision support: making the practice of evidence-based medicine a reality. J Am Med Inform Assoc 10(6):523–530, 2003CrossRef
14.
Zurück zum Zitat Purcell GP: What makes a good clinical decision support system: we have some answers, but implementing good decision support is still hard. Br Med J 330(7494):740–741, 2005CrossRef Purcell GP: What makes a good clinical decision support system: we have some answers, but implementing good decision support is still hard. Br Med J 330(7494):740–741, 2005CrossRef
15.
Zurück zum Zitat Wears RL, Berg M: Computer technology and clinical work: still waiting for Godot. J Am Med Assoc 293(10):1261–1263, 2005CrossRef Wears RL, Berg M: Computer technology and clinical work: still waiting for Godot. J Am Med Assoc 293(10):1261–1263, 2005CrossRef
16.
Zurück zum Zitat C. Hu, R. Ju, Y. Shen, P. Zhou, and Q. Li: Clinical decision support for Alzheimer’s disease based on deep learning and brain network. In 2016 IEEE International Conference on Communications (ICC), pages 1–6, 2016. C. Hu, R. Ju, Y. Shen, P. Zhou, and Q. Li: Clinical decision support for Alzheimer’s disease based on deep learning and brain network. In 2016 IEEE International Conference on Communications (ICC), pages 1–6, 2016.
17.
Zurück zum Zitat L. Getoor and B. Taskar. Introduction to Statistical Relational Learning. MIT Press, 2007. L. Getoor and B. Taskar. Introduction to Statistical Relational Learning. MIT Press, 2007.
18.
Zurück zum Zitat De Raedt L, Kersting K, Natarajan S, Poole D: Statistical Relational Artificial Intelligence: Logic, Probability, and Computation, volume 32 of Synthesis Lectures on Artificial Intelligence and Machine Learning. San Rafael, CA: Morgan & Claypool, 2016 De Raedt L, Kersting K, Natarajan S, Poole D: Statistical Relational Artificial Intelligence: Logic, Probability, and Computation, volume 32 of Synthesis Lectures on Artificial Intelligence and Machine Learning. San Rafael, CA: Morgan & Claypool, 2016
19.
Zurück zum Zitat Sriraam Natarajan, Kristian Kersting, Tushar Khot, and Jude W. Shavlik: Boosted Statistical Relational Learners—From Benchmarks to Data-Driven Medicine. Springer Briefs in Computer Science. Springer, 2014. Sriraam Natarajan, Kristian Kersting, Tushar Khot, and Jude W. Shavlik: Boosted Statistical Relational Learners—From Benchmarks to Data-Driven Medicine. Springer Briefs in Computer Science. Springer, 2014.
20.
Zurück zum Zitat S. Yang, T. Khot, K. Kersting, G. Kunapuli, K. Hauser, and S. Natarajan: Learning from imbalanced data in relational domains: a soft margin approach. In 2014 IEEE International Conference on Data Mining (ICDM), pages 1085–1090, 2014. S. Yang, T. Khot, K. Kersting, G. Kunapuli, K. Hauser, and S. Natarajan: Learning from imbalanced data in relational domains: a soft margin approach. In 2014 IEEE International Conference on Data Mining (ICDM), pages 1085–1090, 2014.
21.
Zurück zum Zitat Weiss JC, Natarajan S, Peissig PL, McCarty CA, Page D: Machine learning for personalized medicine: predicting primary myocardial infarction from electronic health records. AI Mag 33(4):33, 2012CrossRef Weiss JC, Natarajan S, Peissig PL, McCarty CA, Page D: Machine learning for personalized medicine: predicting primary myocardial infarction from electronic health records. AI Mag 33(4):33, 2012CrossRef
22.
Zurück zum Zitat D. Page, S. Natarajan, V. Santos Costa, P. Peissig, A. Barnard, and M. Caldwell: Identifying adverse drug events from multi-relational healthcare data. In Proceedings of AAAI Conference on Artificial Intelligence, pages 790–793, 2012. D. Page, S. Natarajan, V. Santos Costa, P. Peissig, A. Barnard, and M. Caldwell: Identifying adverse drug events from multi-relational healthcare data. In Proceedings of AAAI Conference on Artificial Intelligence, pages 790–793, 2012.
23.
Zurück zum Zitat Haley MacLeod, Shuo Yang, Kim Oakes, Kay Connelly, and Sriraam Natarajan. Identifying rare diseases from behavioural data: a machine learning approach. In Proceedings of the 2016 IEEE First International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE), 2016. Haley MacLeod, Shuo Yang, Kim Oakes, Kay Connelly, and Sriraam Natarajan. Identifying rare diseases from behavioural data: a machine learning approach. In Proceedings of the 2016 IEEE First International Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE), 2016.
24.
Zurück zum Zitat Natarajan S, Saha BN, Joshi S, Edwards A, Khot T, port EMD, Kersting K, Whitlow CT, Maldjian JA: Relational learning helps in three-way classification of Alzheimer patients from structural magnetic resonance images of the brain. Int J Mach Learn Cybern 5:659–669, 2014CrossRef Natarajan S, Saha BN, Joshi S, Edwards A, Khot T, port EMD, Kersting K, Whitlow CT, Maldjian JA: Relational learning helps in three-way classification of Alzheimer patients from structural magnetic resonance images of the brain. Int J Mach Learn Cybern 5:659–669, 2014CrossRef
25.
Zurück zum Zitat Chen F, Huhdanpaa H, Desai B, Hwang D, Cen S, Sherrod A, Bernhard J-C, Desai M, Gill I, Duddalwar V: Whole lesion quantitative CT evaluation of renal cell carcinoma: differentiation of clear cell from papillary renal cell carcinoma. SpringerPlus 4(1):66, 2015CrossRef Chen F, Huhdanpaa H, Desai B, Hwang D, Cen S, Sherrod A, Bernhard J-C, Desai M, Gill I, Duddalwar V: Whole lesion quantitative CT evaluation of renal cell carcinoma: differentiation of clear cell from papillary renal cell carcinoma. SpringerPlus 4(1):66, 2015CrossRef
26.
Zurück zum Zitat Yap F, Hwang D, Cen S, Zhang X, de Castro Abreu AL, Desai M, Aron M, Gill I, Duddalwar V: The shapely renal mass: contour evaluation of renal cell carcinoma. J Urol 195(4):e204, 2016CrossRef Yap F, Hwang D, Cen S, Zhang X, de Castro Abreu AL, Desai M, Aron M, Gill I, Duddalwar V: The shapely renal mass: contour evaluation of renal cell carcinoma. J Urol 195(4):e204, 2016CrossRef
27.
Zurück zum Zitat Bino Abel Varghese, Frank Chen, Darryl Hwang, Steven Cen, Inderbir Gill, and Vinay Duddalwar: Differentiation of predominantly solid, enhancing lipid-poor renal cell masses using contrast-enhanced computed tomography: evaluating the role of texture in tumor sub-typing. Am J Roentgenol, accepted (to appear), 2018. Bino Abel Varghese, Frank Chen, Darryl Hwang, Steven Cen, Inderbir Gill, and Vinay Duddalwar: Differentiation of predominantly solid, enhancing lipid-poor renal cell masses using contrast-enhanced computed tomography: evaluating the role of texture in tumor sub-typing. Am J Roentgenol, accepted (to appear), 2018.
28.
Zurück zum Zitat C. G. Ugwueze, M. Nayyar, Darryl Hwang, Steven Cen, Felix Yap, Bhushan Desai, Inderbir S. Gill, M Desai, and Vinay Duddalwar. Texture analysis as an image-based discriminator between T1 renal cell carcinoma and pT3 renal cell carcinoma. RSNA Annual Meeting, Chicago, 2016. C. G. Ugwueze, M. Nayyar, Darryl Hwang, Steven Cen, Felix Yap, Bhushan Desai, Inderbir S. Gill, M Desai, and Vinay Duddalwar. Texture analysis as an image-based discriminator between T1 renal cell carcinoma and pT3 renal cell carcinoma. RSNA Annual Meeting, Chicago, 2016.
29.
Zurück zum Zitat Chen F, Gulati M, Hwang D, Cen S, Yap F, Ugwueze C, Varghese B, Desai M, Aron M, Gill I, Duddalwar V: Voxel-based whole-lesion enhancement parameters: a study of its clinical value in differentiating clear cell renal cell carcinoma from renal oncocytoma. Abdom Radiol 42(2):552–560, 2017CrossRef Chen F, Gulati M, Hwang D, Cen S, Yap F, Ugwueze C, Varghese B, Desai M, Aron M, Gill I, Duddalwar V: Voxel-based whole-lesion enhancement parameters: a study of its clinical value in differentiating clear cell renal cell carcinoma from renal oncocytoma. Abdom Radiol 42(2):552–560, 2017CrossRef
30.
Zurück zum Zitat Francesco Giuseppe Mazzei, Maria Antonietta Mazzei, Nevada Cioffi Squitieri, et al. CT perfusion in the characterisation of renal lesions: an added value to multiphasic CT. BioMed Res Int, 2014, 2014. Article ID: 135013 Francesco Giuseppe Mazzei, Maria Antonietta Mazzei, Nevada Cioffi Squitieri, et al. CT perfusion in the characterisation of renal lesions: an added value to multiphasic CT. BioMed Res Int, 2014, 2014. Article ID: 135013
31.
Zurück zum Zitat Haralick RM, Shanmugam K, Dinstein I: Textural features for image classification. IEEE Trans Syst Man Cybern SMC-3(6):610–621, 1973CrossRef Haralick RM, Shanmugam K, Dinstein I: Textural features for image classification. IEEE Trans Syst Man Cybern SMC-3(6):610–621, 1973CrossRef
32.
Zurück zum Zitat Bino A. Varghese, Darryl H. Hwang, Steven Y. Cen, Bhushan B. Desai, Felix Yap, Inderbir Gill, Mihir Desai, Manju Aron, Gangning Liang, Michael Chang, Christopher Deng, Mike Kwon, Chidubem Ugweze, Frank Chen, and Vinay A. Duddalwar. Fast Fourier transform-based analysis of renal masses on contrast-enhanced computed tomography images for grading of tumor. In Proceedings Volume 10160, 12th International Symposium on Medical Information Processing and Analysis, 2017. Bino A. Varghese, Darryl H. Hwang, Steven Y. Cen, Bhushan B. Desai, Felix Yap, Inderbir Gill, Mihir Desai, Manju Aron, Gangning Liang, Michael Chang, Christopher Deng, Mike Kwon, Chidubem Ugweze, Frank Chen, and Vinay A. Duddalwar. Fast Fourier transform-based analysis of renal masses on contrast-enhanced computed tomography images for grading of tumor. In Proceedings Volume 10160, 12th International Symposium on Medical Information Processing and Analysis, 2017.
33.
Zurück zum Zitat Guyon I, Weston J, Barnhill S, Vapnik V: Gene selection for cancer classification using support vector machines. Mach Learn 46(1):389–422, 2002CrossRef Guyon I, Weston J, Barnhill S, Vapnik V: Gene selection for cancer classification using support vector machines. Mach Learn 46(1):389–422, 2002CrossRef
34.
Zurück zum Zitat Cortes C, Vapnik V: Support-vector networks. Mach Learn 20(3):273–297, 1995 Cortes C, Vapnik V: Support-vector networks. Mach Learn 20(3):273–297, 1995
35.
Zurück zum Zitat Kevin P. Murphy. Machine Learning: A Probabilistic Perspective. The MIT Press, 2012. Kevin P. Murphy. Machine Learning: A Probabilistic Perspective. The MIT Press, 2012.
36.
Zurück zum Zitat P. McCullagh and John A. Nelder. Generalized Linear Models, 2nd edition. Chapman & Hall/CRC Monographs on Statistics & Applied Probability. Chapman and Hall/CRC, 1989. P. McCullagh and John A. Nelder. Generalized Linear Models, 2nd edition. Chapman & Hall/CRC Monographs on Statistics & Applied Probability. Chapman and Hall/CRC, 1989.
37.
Zurück zum Zitat John Shawe-Taylor and Nello Cristianini. Kernel Methods for Pattern Analysis. Cambridge University Press, 2004. John Shawe-Taylor and Nello Cristianini. Kernel Methods for Pattern Analysis. Cambridge University Press, 2004.
38.
Zurück zum Zitat Leo Breiman, Jerome H. Friedman, R. A. Olshen, and C. J. Stone. Classification and Regression Trees. Wadsworth & Brooks/Cole Advanced Books & Software, 1984. Leo Breiman, Jerome H. Friedman, R. A. Olshen, and C. J. Stone. Classification and Regression Trees. Wadsworth & Brooks/Cole Advanced Books & Software, 1984.
39.
Zurück zum Zitat Robert E. Schapire. A brief introduction to boosting. In Proceedings of the 16th International Joint Conference on Artificial Intelligence—Volume 2, pages 1401–1406, 1999. Robert E. Schapire. A brief introduction to boosting. In Proceedings of the 16th International Joint Conference on Artificial IntelligenceVolume 2, pages 1401–1406, 1999.
40.
Zurück zum Zitat Breiman L: Bagging predictors. Mach Learn 24(2):123–140, 1996 Breiman L: Bagging predictors. Mach Learn 24(2):123–140, 1996
43.
Zurück zum Zitat Druzhkov PN, Kustikova VD: A survey of deep learning methods and software tools for image classification and object detection. Pattern Recognit Image Anal 26(1):9–15, 2016CrossRef Druzhkov PN, Kustikova VD: A survey of deep learning methods and software tools for image classification and object detection. Pattern Recognit Image Anal 26(1):9–15, 2016CrossRef
44.
Zurück zum Zitat Litjens G, Kooi T, Bejnordi BE, Setio AAA, Ciompi F, Ghafoorian M, van der Laak JAWM, van Ginneken B, Snchez CI: A survey on deep learning in medical image analysis. Med Image Anal 42:60–88, 2017CrossRef Litjens G, Kooi T, Bejnordi BE, Setio AAA, Ciompi F, Ghafoorian M, van der Laak JAWM, van Ginneken B, Snchez CI: A survey on deep learning in medical image analysis. Med Image Anal 42:60–88, 2017CrossRef
45.
Zurück zum Zitat Andrearczyk V, Whelan PF: Using filter banks in convolutional neural networks for texture classification. Pattern Recogn Lett 84:63–69, 2016CrossRef Andrearczyk V, Whelan PF: Using filter banks in convolutional neural networks for texture classification. Pattern Recogn Lett 84:63–69, 2016CrossRef
46.
Zurück zum Zitat P. Domingos and D. Lowd. Markov Logic: An Interface Layer for Artificial Intelligence. Morgan & Claypool Publishers, 2009. P. Domingos and D. Lowd. Markov Logic: An Interface Layer for Artificial Intelligence. Morgan & Claypool Publishers, 2009.
47.
Zurück zum Zitat J.H. Friedman: Greedy function approximation: a gradient boosting machine. Ann Stat 29, 2001. J.H. Friedman: Greedy function approximation: a gradient boosting machine. Ann Stat 29, 2001.
48.
Zurück zum Zitat Natarajan S, Khot T, Kersting K, Gutmann B, Shavlik J: Gradient-based boosting for statistical relational learning: the relational dependency network case. Mach Learn 86(1):25–56, 2012CrossRef Natarajan S, Khot T, Kersting K, Gutmann B, Shavlik J: Gradient-based boosting for statistical relational learning: the relational dependency network case. Mach Learn 86(1):25–56, 2012CrossRef
49.
Zurück zum Zitat Blockeel H, De Raedt L: Top-down induction of first-order logical decision trees. Artif Intell 101:285–297, 1998CrossRef Blockeel H, De Raedt L: Top-down induction of first-order logical decision trees. Artif Intell 101:285–297, 1998CrossRef
50.
Zurück zum Zitat Shin T, Duddalwar VA, Ukimura O, Matsugasumi T, Chen F, Ahmadi N, de Castro Abreu AL, Mimata H, Gill IS: Does computed tomography still have limitations to distinguish benign from malignant renal tumors for radiologists? Urol Int 99(2):229–236, 2017CrossRef Shin T, Duddalwar VA, Ukimura O, Matsugasumi T, Chen F, Ahmadi N, de Castro Abreu AL, Mimata H, Gill IS: Does computed tomography still have limitations to distinguish benign from malignant renal tumors for radiologists? Urol Int 99(2):229–236, 2017CrossRef
51.
Zurück zum Zitat Yap FY, Hwang DH, Cen SY, Varghese BA, Desai B, Quinn BD, Gupta MN, Rajarubendra N, Desai MM, Aron M, Liang G, Aron M, Gill IS, Duddalwar VA: Quantitative contour analysis as an image-based discriminator between benign and malignant renal tumors. Urology 114:121–127, 2018CrossRef Yap FY, Hwang DH, Cen SY, Varghese BA, Desai B, Quinn BD, Gupta MN, Rajarubendra N, Desai MM, Aron M, Liang G, Aron M, Gill IS, Duddalwar VA: Quantitative contour analysis as an image-based discriminator between benign and malignant renal tumors. Urology 114:121–127, 2018CrossRef
Metadaten
Titel
A Decision-Support Tool for Renal Mass Classification
verfasst von
Gautam Kunapuli
Bino A. Varghese
Priya Ganapathy
Bhushan Desai
Steven Cen
Manju Aron
Inderbir Gill
Vinay Duddalwar
Publikationsdatum
06.07.2018
Verlag
Springer International Publishing
Erschienen in
Journal of Imaging Informatics in Medicine / Ausgabe 6/2018
Print ISSN: 2948-2925
Elektronische ISSN: 2948-2933
DOI
https://doi.org/10.1007/s10278-018-0100-0

Weitere Artikel der Ausgabe 6/2018

Journal of Digital Imaging 6/2018 Zur Ausgabe

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.