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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Public Health 1/2015

A dengue outbreak on a floating village at Cat Ba Island in Vietnam

Zeitschrift:
BMC Public Health > Ausgabe 1/2015
Autoren:
Thanh Le Viet, Marc Choisy, Juliet E. Bryant, Duoc Vu Trong, Thai Pham Quang, Peter Horby, Hien Nguyen Tran, Huong Tran Thi Kieu, Trung Nguyen Vu, Kinh Nguyen Van, Mai Le Quynh, Heiman FL Wertheim
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12889-015-2235-y) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

TLV collected GPS data, conducted analyses, outlined and wrote the manuscript. HW, MC participated in writing and revising the manuscript. TPQ, DVT, MLQ, JEB, HNT, PH, TNV, KNV supported collecting data and contributed to revising. HTTK performed sequencing DENV samples. All authors participated in discussion of results, read and approved the final manuscript.

Abstract

Background

A dengue outbreak in an ecotourism destination spot in Vietnam, from September to November 2013, impacted a floating village of fishermen on the coastal island of Cat Ba. The outbreak raises questions about how tourism may impact disease spread in rural areas.

Methods

Epidemiological data were obtained from the Hai Phong Preventive Medical Center (PMC), including case histories and residential location from all notified dengue cases from this outbreak. All household addresses were geo-located. Knox test, a spatio-temporal analysis that enables inference dengue clustering constrained by space and time, was performed on the geocoded locations. From the plasma available from two patients, positive for Dengue serotype 3 virus (DENV3), the Envelope (E) gene was sequenced, and their genetic relationships compared to other E sequences in the region.

Results

Of 192 dengue cases, the odds ratio of contracting dengue infections for people living in the floating villages compared to those living on the island was 4.9 (95 % CI: 3.6-6.7). The space-time analyses on 111 geocoded dengue residences found the risk of dengue infection to be the highest within 4 days and a radius of 20 m of a given case. Of the total of ten detected clusters with an excess risk greater than 2, the cluster with the highest number of cases was in the floating village area (24 patients for a total duration of 31 days). Phylogenetic analysis revealed a high homology of the two DENV3 strains (genotype III) from Cat Ba with DENV3 viruses circulating in Hanoi in the same year (99.1 %).

Conclusions

Our study showed that dengue transmission is unlikely to be sustained on Cat Ba Island and that the 2013 epidemic likely originated through introduction of viruses from the mainland, potentially Hanoi. These findings suggest that prevention efforts should be focused on mainland rather than on the island.
Zusatzmaterial
Additional file 1: Animation of occurrence of dengue cases on Cat Ba Island. The animation movie (file: dengue.avi) shows the occurrence of dengue cases by date during 60 days of the outbreak. (AVI 659 kb)
12889_2015_2235_MOESM1_ESM.avi
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