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Erschienen in: Cancer Immunology, Immunotherapy 7/2007

01.07.2007 | Original Article

A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma

verfasst von: Ying-hua Lan, Yong-guo Li, Zeng-wei Liang, Min Chen, Ming-li Peng, Li Tang, Huai-dong Hu, Hong Ren

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 7/2007

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Abstract

Alpha-Fetoprotein (AFP) is produced principally in fetal liver, gastrointestinal tract and the yolk sac which is temporarily present during embryonic development. AFP is overexpressed in the majority of Hepatocellular Carcinoma (HCC) and thus offers an attractive target for immunotherapy against this neoplasm. Here, we report that anti-HCC effects were achieved in a therapeutic setting with a DNA vaccine encoding mouse AFP and co-expressing Heat Shock Protein 70 (HSP70) gene. We also demonstrated that this vaccine elicited a marked and highly effective AFP specific CTL response against AFP-positive target cells. This vaccine also induced the prolongation of life span in mice bearing the tumor and the eradication of HCC. It is anticipated that vaccine strategies such as this may contribute to the effective future treatment of Hepatocellular Carcinoma.
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Metadaten
Titel
A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma
verfasst von
Ying-hua Lan
Yong-guo Li
Zeng-wei Liang
Min Chen
Ming-li Peng
Li Tang
Huai-dong Hu
Hong Ren
Publikationsdatum
01.07.2007
Verlag
Springer-Verlag
Erschienen in
Cancer Immunology, Immunotherapy / Ausgabe 7/2007
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-006-0254-3

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