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06.12.2019 | Case Report

A fatal case report of acute yohimbine intoxication

verfasst von: Guillaume Drevin, Maeva Palayer, Patricia Compagnon, Donca Zabet, Nathalie Jousset, Marie Briet, Chadi Abbara

Erschienen in: Forensic Toxicology

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Abstract

Purpose

Yohimbine is an indole alkaloid extracted from the bark of the Pausinystalia yohimbe tree, which has found a clinical application through the treatment of erectile dysfunction. Yohimbine is also widely used by the bodybuilding community for its sympathomimetic effects and its presumed lipolytic effects. This substance is, however, associated with adverse effects, including cardiac and neurologic side-effects, but only few fatal cases have been described to date. In this context, this manuscript aims at documenting a fatal case of a 27-year-old male.

Methods

Ethanol concentration determination and toxicological screening were performed using gas chromatography with flame ionization detection, liquid chromatography with diode array detection and gas chromatography with mass spectrometry detection. Liquid chromatography with diode array detection allowed the quantification of yohimbine.

Results

Toxicological analysis of subclavian blood, vitreous humor, and urine samples highlighted the presence of yohimbine and tramadol. Yohimbine was quantified at the concentration of 8000 µg/L in the peripheral blood and 2600 µg/L in the vitreous humor. Tramadol blood concentration was below the toxic threshold.

Conclusion

Only a very few number of yohimbine fatalities has been reported so far. In the current case, yohimbine acute intoxication appeared to be the most likely cause of death. In fact, the blood concentration highlighted here is the highest ever reported to date.
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Metadaten
Titel
A fatal case report of acute yohimbine intoxication
verfasst von
Guillaume Drevin
Maeva Palayer
Patricia Compagnon
Donca Zabet
Nathalie Jousset
Marie Briet
Chadi Abbara
Publikationsdatum
06.12.2019
Verlag
Springer Singapore
Erschienen in
Forensic Toxicology
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-019-00512-y

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