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European Journal of Applied Physiology

Erschienen in:

06.03.2020 | Invited Review

A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise

verfasst von: Stephen M. Cornish, Eric M. Bugera, Todd A. Duhamel, Jason D. Peeler, Judy E. Anderson

Erschienen in: European Journal of Applied Physiology | Ausgabe 5/2020

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Abstract

Purpose

Resistance exercise induces muscle growth and is an important treatment for age-related losses in muscle mass and strength. Myokines are hypothesized as a signal conveying physiological information to skeletal muscle, possibly to “fine-tune” other regulatory pathways. While myokines are released from skeletal muscle following contraction, their role in increasing muscle mass and strength in response to resistance exercise or training is not established. Recent research identified both local and systemic release of myokines after an acute bout of resistance exercise. However, it is not known whether myokines with putative anabolic function are mechanistically involved in producing muscle hypertrophy after resistance exercise. Further, nitric oxide (NO), an important mediator of muscle stem cell activation, upregulates the expression of certain myokine genes in skeletal muscle.

Method

In the systemic context of complex hypertrophic signaling, this review: (1) summarizes literature on several well-recognized, representative myokines with anabolic potential; (2) explores the potential mechanistic role of myokines in skeletal muscle hypertrophy; and (3) identifies future research required to advance our understanding of myokine anabolism specifically in skeletal muscle.

Result

This review establishes a link between myokines and NO production, and emphasizes the importance of considering systemic release of potential anabolic myokines during resistance exercise as complementary to other signals that promote hypertrophy.

Conclusion

Investigating adaptations to resistance exercise in aging opens a novel avenue of interdisciplinary research into myokines and NO metabolites during resistance exercise, with the longer-term goal to improve muscle health in daily living, aging, and rehabilitation.

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Titel: A focused review of myokines as a potential contributor to muscle hypertrophy from resistance-based exercise
verfasst von: Stephen M. Cornish
Eric M. Bugera
Todd A. Duhamel
Jason D. Peeler
Judy E. Anderson
Publikationsdatum: 06.03.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 5/2020
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-020-04337-1

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