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24.02.2017 | Original Article | Ausgabe 3/2017

Comparative Clinical Pathology 3/2017

A glutamine and glutamate mixture and its effects on the hematological and biochemical biomarkers in dogs

Zeitschrift:
Comparative Clinical Pathology > Ausgabe 3/2017
Autoren:
Simone Gutman Vaz, Telga Lucena Alves Craveiro de Almeida, Eduardo Terra Nogueira, Mariane Kutschenko, Hélio Cordeiro Manso Filho, Helena Emília Cavalcanti da Costa Cordeiro Manso

Abstract

Glutamine has been considered an important agent in the treatment of diseases that lead to hypermetabolic states. Its administration can improve immune response and maintain the integrity of the intestinal mucosa and nitrogen balance, minimizing catabolic effects of diseases. To evaluate the absorption curve of mixture of glutamine and glutamate and its effects on different blood biomarkers in canines, ten clinically healthy dogs of large breeds were evaluated. Blood samples were collected seven times: pretest (fasted for 12 h) and then 0.5, 1, 2, 3, 4, and 5 h after supplementation for dosage of Gln, Glu, and hematological and biochemical biomarkers. Results showed increase in Gln during postprandial period with the peak at 5 h after supplementation (P < 0.05) and Glu 1 h after supplementation (P < 0.05), returning to the initial values after 3 h (P > 0.05). Reductions in urate (P < 0.05) were also observed. Variations were not observed in urea, creatinine, total plasma protein (TPP), albumin, globulin, glucose, AST, and ALT (P > 0.05) after supplementation. The concentrations of erythrocytes, hemoglobin, and hematocrit decrease 1 and 2 h after supplementation, while the MCV, MCHC, RDW-SD, and RDW-CV showed no difference (P > 0.05). The platelet count, leukocytes, other cells, lymphocytes, and eosinophils did not change (P > 0.05) throughout the postprandial period. In conclusion, supplementation with a mixture of glutamine and glutamate was able to raise the concentration of these amino acids in the blood of healthy dogs, without changes in blood protein biomarkers and any adverse reaction.

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