Erschienen in:
15.02.2019 | Original Article—Alimentary Tract
A Helicobacter pylori screening and treatment program to eliminate gastric cancer among junior high school students in Saga Prefecture: a preliminary report
verfasst von:
Toshihiko Kakiuchi, Muneaki Matsuo, Hiroyoshi Endo, Aiko Nakayama, Keiko Sato, Ayako Takamori, Kazumi Sasaki, Mitsuhiro Takasaki, Megumi Hara, Yasuhisa Sakata, Masumi Okuda, Shogo Kikuchi, Yuichiro Eguchi, Hirokazu Takahashi, Keizo Anzai, Kazuma Fujimoto
Erschienen in:
Journal of Gastroenterology
|
Ausgabe 8/2019
Einloggen, um Zugang zu erhalten
Abstract
Background
To present the strategies and preliminary findings of the first 3 years after implementing a Helicobacter pylori screening and eradication program to prevent gastric cancer in Saga Prefecture.
Methods
A screening and treatment program to eradicate H. pylori from third-grade junior high students was started in Saga Prefecture in 2016, using local governmental grants. Screening was with urinary anti-H. pylori antibody tests, followed by H. pylori stool antigen tests for students who were antibody positive. Those positive on both tests underwent H. pylori eradication by triple therapy based on a potassium-competitive acid blocker.
Results
From 2016 to 2018, the participation rate was 83.1% and the H. pylori infection rate was 3.1% (660/21,042). The participation rates were higher in 2017 (85.4%) and 2018 (85.9%) compared with 2016 (78.5%) (P < 0.0001), and the infection rate also decreased in a time-dependent manner (2016: 3.6%, 2017: 3.3%, 2018: 2.5%, P = 0.0001). In total, 501 students positive for H. pylori received eradication therapy (85.1% success) and adverse events occurred in 20 of these (4.0%). However, no serious complications occurred.
Conclusions
The H. pylori screening and eradication project for school students in Saga Prefecture has started successfully and we have seen both a steady increase in the participation rate and a steady decrease in the infection rate, without major safety concerns.