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01.12.2012 | Case report | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Laurens Manning, Anna Rosanas-Urgell, Moses Laman, Henry Edoni, Catriona McLean, Ivo Mueller, Peter Siba, Timothy ME Davis
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-107) contains supplementary material, which is available to authorized users.
Laurens Manning, Anna Rosanas-Urgell contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

LM co-ordinated the main study, obtained biopsies and produced the initial draft of the paper. AR-U performed the PCR assays and edited drafts of the paper. ML assisted clinically with the main study, obtained biopsies and edited drafts of the paper. HE assisted with data collection and specimen preparation, and edited drafts of the paper. CM performed the histological examination of brain tissue and edited drafts of the paper. IM was a co-investigator on the main study and edited drafts of the paper. PS was a co-investigator on the main study and edited drafts of the paper. TMED was the principal investigator of the main study, conceived the sub-study and produced the final version of the paper. All authors read and approved the final manuscript.

Abstract

Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. vivax infections are more likely to develop cerebral malaria and die than those with P. falciparum alone, possibly reflecting P. vivax sequestration. Nested PCR was performed on post mortem brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain.
Zusatzmaterial
Authors’ original file for figure 1
12936_2011_2091_MOESM1_ESM.tiff
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