Skip to main content
main-content
Erschienen in: Brain Structure and Function 1/2018

26.07.2017 | Original Article

A large-scale study on the effects of sex on gray matter asymmetry

verfasst von: Christian Núñez, Constantina Theofanopoulou, Carl Senior, Maria Rosa Cambra, Judith Usall, Christian Stephan-Otto, Gildas Brébion

Erschienen in: Brain Structure and Function | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Research on sex-related brain asymmetries has not yielded consistent results. Despite its importance to further understanding of normal brain development and mental disorders, the field remains relatively unexplored. Here we employ a recently developed asymmetry measure, based on the Dice coefficient, to detect sex-related gray matter asymmetries in a sample of 457 healthy participants (266 men and 191 women) obtained from 5 independent databases. Results show that women’s brains are more globally symmetric than men’s (p < 0.001). Although the new measure accounts for asymmetries distributed all over the brain, several specific structures were identified as systematically more symmetric in women, such as the thalamus and the cerebellum, among other structures, some of which are typically involved in language production. These sex-related asymmetry differences may be defined at the neurodevelopmental stage and could be associated with functional and cognitive sex differences, as well as with proneness to develop a mental disorder.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Zurück zum Zitat Gollub RL, Shoemaker JM, King MD, White T, Ehrlich S, Sponheim SR, Clark VP, Turner JA, Mueller BA, Magnotta V, O’Leary D, Ho BC, Brauns S, Manoach DS, Seidman L, Bustillo JR, Lauriello J, Bockholt J, Lim KO, Rosen BR, Schulz SC, Calhoun VD, Andreasen NC (2013) The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics 11:367–388. doi: 10.​1007/​s12021-013-9184-3 CrossRefPubMedPubMedCentral Gollub RL, Shoemaker JM, King MD, White T, Ehrlich S, Sponheim SR, Clark VP, Turner JA, Mueller BA, Magnotta V, O’Leary D, Ho BC, Brauns S, Manoach DS, Seidman L, Bustillo JR, Lauriello J, Bockholt J, Lim KO, Rosen BR, Schulz SC, Calhoun VD, Andreasen NC (2013) The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics 11:367–388. doi: 10.​1007/​s12021-013-9184-3 CrossRefPubMedPubMedCentral
Zurück zum Zitat Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14:685–700. doi: 10.​1006/​nimg.​2001.​0857 CrossRefPubMed Good CD, Johnsrude I, Ashburner J, Henson RN, Friston KJ, Frackowiak RS (2001) Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage 14:685–700. doi: 10.​1006/​nimg.​2001.​0857 CrossRefPubMed
Zurück zum Zitat Gorgolewski KJ, Varoquaux G, Rivera G, Schwarz Y, Ghosh SS, Maumet C, Sochat VV, Nichols TE, Poldrack RA, Poline JB, Yarkoni T, Margulies DS (2015) NeuroVault.org: a web-based repository for collecting and sharing unthresholded statistical maps of the human brain. Front Neuroinform 9:8. doi: 10.​3389/​fninf.​2015.​00008 CrossRefPubMedPubMedCentral Gorgolewski KJ, Varoquaux G, Rivera G, Schwarz Y, Ghosh SS, Maumet C, Sochat VV, Nichols TE, Poldrack RA, Poline JB, Yarkoni T, Margulies DS (2015) NeuroVault.org: a web-based repository for collecting and sharing unthresholded statistical maps of the human brain. Front Neuroinform 9:8. doi: 10.​3389/​fninf.​2015.​00008 CrossRefPubMedPubMedCentral
Zurück zum Zitat Guadalupe T, Zwiers MP, Wittfeld K, Teumer A, Vasquez AA, Hoogman M, Hagoort P, Fernandez G, Buitelaar J, van Bokhoven H, Hegenscheid K, Völzke H, Franke B, Fisher SE, Grabe HJ, Francks C (2015) Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity. Cortex 62:41–55. doi: 10.​1016/​j.​cortex.​2014.​07.​015 CrossRefPubMed Guadalupe T, Zwiers MP, Wittfeld K, Teumer A, Vasquez AA, Hoogman M, Hagoort P, Fernandez G, Buitelaar J, van Bokhoven H, Hegenscheid K, Völzke H, Franke B, Fisher SE, Grabe HJ, Francks C (2015) Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity. Cortex 62:41–55. doi: 10.​1016/​j.​cortex.​2014.​07.​015 CrossRefPubMed
Zurück zum Zitat Guadalupe T, Mathias SR, vanErp TG, Whelan CD, Zwiers MP, Abe Y, Abramovic L, Agartz I, Andreassen OA, Arias-Vásquez A, Aribisala BS, Armstrong NJ, Arolt V, Artiges E, Ayesa-Arriola R, Baboyan VG, Banaschewski T, Barker G et al (2016) Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging Behav. doi: 10.​1007/​s11682-016-9629-z (in press) PubMedCentral Guadalupe T, Mathias SR, vanErp TG, Whelan CD, Zwiers MP, Abe Y, Abramovic L, Agartz I, Andreassen OA, Arias-Vásquez A, Aribisala BS, Armstrong NJ, Arolt V, Artiges E, Ayesa-Arriola R, Baboyan VG, Banaschewski T, Barker G et al (2016) Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex. Brain Imaging Behav. doi: 10.​1007/​s11682-016-9629-z (in press) PubMedCentral
Zurück zum Zitat Muntané G, Santpere G, Verendeev A, Seeley WW, Jacobs B, Hopkins WD, Navarro A, Sherwood CC (2017) Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys. Brain Struct Funct. doi: 10.​1007/​s00429-017-1401-7 (in press) Muntané G, Santpere G, Verendeev A, Seeley WW, Jacobs B, Hopkins WD, Navarro A, Sherwood CC (2017) Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys. Brain Struct Funct. doi: 10.​1007/​s00429-017-1401-7 (in press)
Zurück zum Zitat Núñez C, Paipa N, Senior C, Coromina M, Siddi S, Ochoa S, Brébion G, Stephan-Otto C (2017) Global brain asymmetry is increased in schizophrenia and related to avolition. Acta Psychiatr Scand 135:448–459. doi: 10.​1111/​acps.​12723 CrossRefPubMed Núñez C, Paipa N, Senior C, Coromina M, Siddi S, Ochoa S, Brébion G, Stephan-Otto C (2017) Global brain asymmetry is increased in schizophrenia and related to avolition. Acta Psychiatr Scand 135:448–459. doi: 10.​1111/​acps.​12723 CrossRefPubMed
Zurück zum Zitat Vernooij MW, Smits M, Wielopolski PA, Houston GC, Krestin GP, van der Lugt A (2007) Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study. Neuroimage 35:1064–1076. doi: 10.​1016/​j.​neuroimage.​2006.​12.​041 CrossRefPubMed Vernooij MW, Smits M, Wielopolski PA, Houston GC, Krestin GP, van der Lugt A (2007) Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study. Neuroimage 35:1064–1076. doi: 10.​1016/​j.​neuroimage.​2006.​12.​041 CrossRefPubMed
Zurück zum Zitat Yücel M, Stuart GW, Maruff P, Velakoulis D, Crowe SF, Savage G, Pantelis C (2001) Hemispheric and gender-related differences in the gross morphology of the anterior cingulate/paracingulate cortex in normal volunteers: an MRI morphometric study. Cereb Cortex 11:17–25. doi: 10.​1093/​cercor/​11.​1.​17 CrossRefPubMed Yücel M, Stuart GW, Maruff P, Velakoulis D, Crowe SF, Savage G, Pantelis C (2001) Hemispheric and gender-related differences in the gross morphology of the anterior cingulate/paracingulate cortex in normal volunteers: an MRI morphometric study. Cereb Cortex 11:17–25. doi: 10.​1093/​cercor/​11.​1.​17 CrossRefPubMed
Metadaten
Titel
A large-scale study on the effects of sex on gray matter asymmetry
verfasst von
Christian Núñez
Constantina Theofanopoulou
Carl Senior
Maria Rosa Cambra
Judith Usall
Christian Stephan-Otto
Gildas Brébion
Publikationsdatum
26.07.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 1/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-017-1481-4

Weitere Artikel der Ausgabe 1/2018

Brain Structure and Function 1/2018 Zur Ausgabe

Neu im Fachgebiet Neurologie

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Neurologie und bleiben Sie gut informiert – ganz bequem per eMail.