Fig. 1a True pemetrexed clearance versus predicted pemetrexed clearance for dataset 1, LSS 0.5–2–4–8 h. b True pemetrexed clearance versus predicted pemetrexed clearance for dataset 2, LSS 0.5–2–4–8 h. c True pemetrexed clearance versus predicted pemetrexed clearance for dataset 1, LSS 24rs. d True pemetrexed clearance versus predicted pemetrexed clearance for dataset 2, LSS 24 h. e Creatinine clearance versus relative prediction error for dataset 1, LSS 0.5–2–4–8 h. f Creatinine clearance versus relative prediction error for dataset 2, LSS 0.5–2–4–8 h. g Creatinine clearance versus relative prediction error for dataset 1, LSS 24 h. h Creatinine clearance versus relative prediction error for dataset 2, LSS 24 h