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16.10.2018 | Review Article | Ausgabe 4/2018

Oral and Maxillofacial Surgery 4/2018

A literature review of perioperative antibiotic administration in surgery for medication-related osteonecrosis of the jaw

Zeitschrift:
Oral and Maxillofacial Surgery > Ausgabe 4/2018
Autoren:
Masaya Akashi, Junya Kusumoto, Daisuke Takeda, Takashi Shigeta, Takumi Hasegawa, Takahide Komori

Abstract

Purpose

Few studies exist that focus on the details of perioperative antibiotic administration for surgery to treat medication-related osteonecrosis of the jaw (MRONJ). The regime and duration of perioperative antibiotics applied in published studies were reviewed to clarify appropriate perioperative antibiotic use in MRONJ surgery.

Methods

A literature search was conducted using the MEDLINE database via PubMed.

Results

The search resulted in 453 hits on PubMed. After reading the downloaded full-text articles, 17 articles met the inclusion and exclusion criteria. The most common perioperative antibiotic used for MRONJ surgery was a combination of penicillin-based antibiotics and β-lactamase inhibitor (52.9%), and the second most common regime was penicillin-based antibiotics with metronidazole (17.6%). The duration of administration was 2 weeks postoperatively in nine studies, whereas four studies applied long-term administration (2–6 weeks postoperatively).

Conclusions

Oral and maxillofacial surgeons mostly prefer penicillin-based antibiotics plus β-lactamase inhibitor or metronidazole for MRONJ surgery. The duration of administration of these medications may be based on empirical experience.

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