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Erschienen in: Forensic Toxicology 1/2020

19.08.2019 | Short Communication

A low-voltage paper spray ionization QTOF-MS method for the qualitative analysis of NPS in street drug blotter samples

verfasst von: Letícia Birk, Sarah Eller Franco de Oliveira, Gabriela Mafra, Rafael Brognoli, Marcos Jose Souza Carpes, Daniel Scolmeister, Eduardo Carasek, Josias de Oliveira Merib, Tiago Franco de Oliveira

Erschienen in: Forensic Toxicology | Ausgabe 1/2020

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Abstract

Purpose

Analysis of new psychoactive substances (NPS) requires high selective analytical methodologies, including high-resolution mass spectrometry. In addition, the development/application of a suitable sample preparation step can provide methods in which low amounts of solvents and samples are used, as well as minimal sample manipulation is required.

Methods

Herein, the use of ambient ionization techniques such as paper spray emerges as a powerful tool to enhance the performance of methodologies, particularly in forensic sciences. In this study, low-voltage paper spray ionization coupled with quadrupole time-of-flight-mass spectrometry (QTOF-MS) method was developed and employed for the qualitative analysis of NPS in street drug blotter samples.

Results

Analysis revealed the presence of LSD (m/z 324.2058); 25C-NBOH (m/z 322.1212); 25E-NBOH (m/z 316.1917); 25I-NBOMe (m/z 428.0699); DOB (m/z 274.0432); and 4′-fluoro-α-pyrrolidinohexanophenone (m/z 264.1768) in the samples analyzed.

Conclusions

This technique was successfully applied for the analysis of NPS and allowed for fast and accurate analytical method that can be highly exploited in forensic screening purposes.
Literatur
8.
Zurück zum Zitat Frison G, Odoardi S, Frasson S, Sciarrone R, Ortar G, Romolo FS, Rossi SS (2015) Characterization of the designer drug bk-2C-B (2-amino-1-(bromo-dimethoxyphenyl)ethan-1-one) by gas chromatography/mass spectrometry without and with derivatization with 2,2,2-trichloroethyl chloroformate, liquid chromatography/high-resolution mass spectrometry, and nuclear magnetic resonance. Rapid Commun Mass Spectrom 29:1196–1204. https://​doi.​org/​10.​1002/​rcm.​721 CrossRefPubMed Frison G, Odoardi S, Frasson S, Sciarrone R, Ortar G, Romolo FS, Rossi SS (2015) Characterization of the designer drug bk-2C-B (2-amino-1-(bromo-dimethoxyphenyl)ethan-1-one) by gas chromatography/mass spectrometry without and with derivatization with 2,2,2-trichloroethyl chloroformate, liquid chromatography/high-resolution mass spectrometry, and nuclear magnetic resonance. Rapid Commun Mass Spectrom 29:1196–1204. https://​doi.​org/​10.​1002/​rcm.​721 CrossRefPubMed
Metadaten
Titel
A low-voltage paper spray ionization QTOF-MS method for the qualitative analysis of NPS in street drug blotter samples
verfasst von
Letícia Birk
Sarah Eller Franco de Oliveira
Gabriela Mafra
Rafael Brognoli
Marcos Jose Souza Carpes
Daniel Scolmeister
Eduardo Carasek
Josias de Oliveira Merib
Tiago Franco de Oliveira
Publikationsdatum
19.08.2019
Verlag
Springer Singapore
Erschienen in
Forensic Toxicology / Ausgabe 1/2020
Print ISSN: 1860-8965
Elektronische ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-019-00496-9

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