nach oben

Quality of Life Research

Erschienen in:

01.12.2011

A meta-analysis of health state valuations for people with diabetes: explaining the variation across methods and implications for economic evaluation

verfasst von: Tom W. C. Lung, Alison J. Hayes, Andrew Hayen, Andrew Farmer, Philip M. Clarke

Erschienen in: Quality of Life Research | Ausgabe 10/2011

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To review published studies on the effect of diabetes and its complications on utility scores to establish whether there is systematic variation across studies and to examine the implications for the estimation of quality-adjusted life years (QALYs).

Methods

A systematic review was performed using studies reporting QALY measures elicited from people with diabetes including those with a history of complications. Meta-analysis was used to obtain the average utility, and meta-regression was employed to examine the impact of study characteristics and elicitation methods on these values. The effect of different utility scores on QALYs was examined using diabetes simulation models.

Results

In the meta-analysis based on 45 studies reporting 66 values, the average utility score was 0.76 (95% CI 0.75–0.77). A meta-regression showed significant variation due to age, method of elicitation and the proportion of males. The average utility score for individual complications ranged from 0.48 (95% CI 0.25, 0.71) for chronic renal disease to 0.75 (95% CI 0.73, 0.78) for myocardial infarction, and these differences produced meaningful changes in simulated QALYs. There was significant heterogeneity between studies.

Conclusions

We provide summary utility scores for diabetes and its major complications that could help inform economic evaluation and policy analysis.

Nur mit Berechtigung zugänglich

Clarke, P. M., Gray, A. M., Briggs, A., et al. (2004). A model to estimate the lifetime health outcomes of patients with Type 2 diabetes: the United Kingdom prospective diabetes study (UKPDS 68) Outcomes Model. Diabetologia, 47, 1747–1759.PubMedCrossRef

Palmer, A. J., Roze, S., Valentine, W. J., et al. (2004). The CORE diabetes model: Projecting long-term clinical outcomes, costs and cost-effectiveness of interventions in diabetes mellitus (Type 1 and 2) to support clinical and reimbursement decision-making. Current Medical Research and Opinion, 20(Suppl), S5–S26.PubMedCrossRef

Herman, W. H., Hoerger, T. J., Brandle, M., Hicks, K., Sorensen, S., Zhang, P., et al. (2005). Diabetes Prevention Program Research Group. The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance. Annals of Internal Medicine, 142(5), 323–332.PubMed

EuroQol Group. (1990). EuroQol–a new facility for the measurement of health-related quality of life. Health Policy, 16(3), 199–208.CrossRef

Horsman, J., Furlong, W., Feeny, D., & Torrance, G. (2003). The Health Utilities Index (HUI®): concepts, measurement properties and applications. Health and Quality of Life Outcomes, 1, 54.PubMedCrossRef

Walters, S. J., & Brazier, J. E. (2003). What is the relationship between the minimally important difference and health state utility values? The case of the SF-6D. Health and Quality of Life Outcomes, 1, 4.PubMedCrossRef

Torrance, G. W. (1986). Measurement of health state utilities for economic appraisal: A review. Journal of Health Economics, 5(1), 1–30.PubMedCrossRef

Bharmal, M., & Thomas, J. (2006). Comparing the EQ-5D and the SF-6D Descriptive Systems to assess their ceiling effects in the US general population. Value in Health, 9(4), 262–271.PubMedCrossRef

Barnett, T. E., Chumbler, N. R., Vogel, B. W., Beyth, R. J., Ryan, P., & Figueroa, S. (2007). The cost-utility of a car coordination/home telehealth programme for veterans with diabetes. Journal of Telemedicine and Telecare, 13(6), 318–321.PubMedCrossRef

10.

Douzdjian, V. (1998). Treatment strategies for insulin-dependent diabetics with ESRD: a cost-effectiveness. American Journal of Kidney Diseases, 31(5), 794–802.PubMedCrossRef

11.

Barofsky, I., Erickson, P., & Eberhardt, M. (2004). Comparison of a single global item and an index of a multi-item health status measure among persons with and without Diabetes in the US. Quality of Life Research, 13(10), 1671–1681.PubMedCrossRef

12.

Chancellor, J., Aballea, S., Lawrence, A., Sheldon, R., Cure, S., Plun-Favreau, J., et al. (2008). Preferences of patients with diabetes mellitus for inhaled versus injectable insulin regimens. Pharmacoeconomics, 26(3), 217–234.PubMedCrossRef

13.

Maddigan, S. L., Feeny, D. G., & Johnson, J. A. (2005). Health-related quality of life deficits associated with diabetes and comorbidities in a Canadian national population health survey. Quality of Life Research, 14(5), 1311–1320.PubMedCrossRef

14.

Sterne, J. A. C., Bradburn M. J., & Egger M. (2001) Meta-analysis in Stata. (Chapter 18) Resource document. Blackwell Publishing.

15.

Hedges, L. V., Tipton, E., & Johnson, M. C. (2010). Robust variance estimation in meta-regression with dependent effect size estimates. Research Synthesis Methods, 1(1), 39–65.CrossRef

16.

Tengs, T. O., & Lin, T. H. (2003). A Meta-analysis of quality-of-life estimates for stroke. Pharmacoeconomics, 21(3), 191–200.PubMedCrossRef

17.

Maddigan, S. L., Feeny, D. H., Johnson, J. A., & Investigators., D. O. V. E. (2004). Construct validity of the RAND-12 and Health Utilities Index Mark 2 and 3 in type 2 diabetes. Quality of Life Research, 13(2), 435–448.PubMedCrossRef

18.

Maddigan, S. L., Majumdar, S. R., Guirguis, L. M., Lewanczuk, R. Z., Lee, T. K., Toth, E. L., et al. (2004). Improvements in patient-reported outcomes associated with an intervention to enhance quality of care for rural patients with type 2 diabetes. Diabetes Care, 27(6), 1306–1312.PubMedCrossRef

19.

Boye, K. S., Matza, L. S., Oglyesby, A., Malley, K., Kim, S., Hayes, R. P. & Brodows, R. (2006). Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes. Health and Quality of Life Outcomes, October 4, 80.

20.

Currie, C. J., Morgan, C. L., Poole, C. D., Sharplin, P., Lammert, M., & McEwan, P. (2006). Multivariate models of health-related utility and the fear of hypoglycaemia in people with diabetes. Current Medical Research and Opinion, 22(8), 1523–1534.PubMedCrossRef

21.

Huang, E. S., Shook, M., Jin, L., Chin, M. H., & Meltzer, D. O. (2006). The impact of patient preferences on the cost-effectiveness of intensive glucose control in older patients with new-onset diabetes. Diabetes Care, 29(2), 259–264.PubMedCrossRef

22.

Ose, D., Wensing, M., Szecsenyi, J., Joos, S., Hermann, K., & Miksch, A. (2009). Impact of primary care-based disease management on the health-related quality of life in patients with type 2 diabetes and comorbidity. Diabetes Care, 32(9), 1594–1596.PubMedCrossRef

23.

Farmer, A. J., Wade, A. N., French, D. P., Simon, J., Yudkin, P., Gray, A., et al. (2009). Blood glucose self-monitoring in type 2 diabetes: a randomised controlled trial. Health Technology Assessment, 13(15), 1–50.

24.

Hammerschmidt, T., Zeitler, H. P., Gulich, M., & Leidl, R. (2004). A comparison of different strategies to collect standard gamble utilities. Medical Decision Making, 24(5), 493–503.PubMedCrossRef

25.

Shah, V. A., Gupta, S. K., Shah, K. V., Vinjamaram, S., & Chalam, K. V. (2004). TTO utility scores measure quality of life in patients with visual morbidity due to diabetic retinopathy or ARMD. Ophthalmic Epidemiology, 11(1), 43–51.PubMedCrossRef

26.

Lundkvist, J., Berne, C., Bolinder, B., & Jönsson, L. (2005). The economic and quality of life impact of hypoglycaemia. European Journal of Health Economics, 6(3), 197–202.PubMedCrossRef

27.

Wee, H. L., Li, S. C., Cheung, Y. B., Fong, K. Y., & Thumboo, J. (2006). The influence of ethnicity on health-related quality of life in diabetes mellitus: a population-based, multiethnic study. Journal of Diabetes and Its Complications, 20(3), 170–178.PubMedCrossRef

28.

Brown, S. E. S., Meltzer, D. O., Chin, M. H., & Huang, E. S. (2008). Perceptions of quality-of-life effects of treatments for diabetes mellitus in vulnerable and nonvulnerable older patients. Journal of the American Geriatrics Society, 56(7), 1183–1190.PubMedCrossRef

29.

Lloyd, A., Nafees, B., Gavriel, S., Rousculp, M. D., Boye, K. S., & Ahmad, A. (2008). Health utility values associated with diabetic retinopathy. Diabetic Medicine, 25(5), 618–624.PubMedCrossRef

30.

Sakthong, P., Charoenvisuthiwongs, R., & Shabunthom, R. (2008). A comparison of EQ-5D index scores using the UK, US and Japan preference weights in a Thai sample with type 2 diabetes. Health and quality of life outcomes, 23(6), 71.CrossRef

31.

McEwen, L. N., Kim, C., Haan, M. N., Ghosh, D., Lantz, P. M., Thompson, T. J., et al. (2009). Are health-related quality-of-life and self-rated health associated with mortality? Insights from translating research into action for diabetes (TRIAD). Primary Care Diabetes, 3(1), 37–42.PubMedCrossRef

32.

ADVANCE Collaborative Group. (2007). Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet, 370, 829–840.CrossRef

33.

Wexler, D. J., Grant, R. W., Wittenburg, E., Bosch, J. L., Cagliero, E., Delahanty, L., et al. (2006). Correlates of health-related quality of life in Type 2 diabetes. Diabetologia, 49, 1489–1497.PubMedCrossRef

34.

Levy, A. R., Christensen, T. L., & Johnson, J. A. (2008). Utility values for symptomatic non-severe hypoglycaemia elicited from persons with and without diabetes in Canada and the United Kingdom. Health and Quality of Life Outcomes, 29(6), 73.CrossRef

35.

Brown, M. M., Brown, G. C., Sharma, S., & Shah, G. (1999). Utility Values and Diabetic Retinopathy. American Journal of Ophthalmology, 128(3), 324–330.PubMedCrossRef

36.

Brown, G. C., Brown, M. M., Sharma, S., Brown, H., Gozum, M., & Denton, P. (2000). Quality of life associated with diabetes mellitus in an adult population. Journal of Diabetes and Its Complications, 14(1), 18–24.PubMedCrossRef

37.

Brown, M. M., Brown, G. C., Sharma, S., Landy, J., & Bakal, J. (2002). Quality of life with visual acuity loss from diabetic retinopathy and age-related macular degeneration. Archives of Ophthalmology, 120(4), 481–484.PubMed

38.

Redekop, W. K., Koopmanschap, M. A., Stolk, R. P., Rutten, G. E., Wolffenbuttel, B. H., & Niessen, L. W. (2002). Health-related quality of life and treatment satisfaction in Dutch patients with type 2 diabetes. Diabetes Care, 25(3), 458–463.PubMedCrossRef

39.

Sullivan, S. D., Lew, D. P., Devine, B. E., Hakim, Z., Reiber, G. E., & Veenstra, D. L. (2002). Health state preference assessment in diabetic peripheral neuropathy. Pharmacoeconomics, 20(15), 1079–1089.PubMedCrossRef

40.

Clarke, P., Gray, A., & Holman, R. (2002). Estimating utility values for health states of type 2 diabetic patients using the EQ-5D (UKPDS 62). Medical Decision Making, 22(4), 340–349.PubMed

41.

Hart, H. E., Bilo, H. J. G., Redekop, W. K., Stolk, R. P., Assink, J. H., & Meyboom-de Jong, B. (2003). Quality of life of patients with type 1 diabetes mellitus. Quality of Life Research, 12(8), 1089–1097.PubMedCrossRef

42.

Sharma, S., Oliver-Fernandez, A., Bakal, J., Hollands, H., Brown, G. C., & Brown, M. M. (2003). Utilities associated with diabetic retinopathy: results from a Canadian sample. The British Journal of Ophthalmology, 87(3), 259–261.PubMedCrossRef

43.

Bagust, A., & Beale, S. (2005). Modelling EuroQol health-related utility values for diabetic complications from CODE-2 data. Health Economics, 14(3), 217–230.PubMedCrossRef

44.

Wee, H. L., Cheung, Y. B., Li, S. C., Fong, K. Y., & Thumboo, J. (2005). The impact of diabetes mellitus and other chronic medical conditions on health-related quality of life: Is the whole greater than the sum of its parts? Health and Quality of Life Outcomes January, 3, 2.CrossRef

45.

Clarke, P. M., Simon, J., Cull, C. A., & Holman, R. R. (2006). Assessing the impact of visual acuity on quality of life in individuals with type 2 diabetes using the short form-36. Diabetes Care, 29(7), 1506–1511.PubMedCrossRef

46.

Morgan, C. L., McEwan, P., Morrissey, M., Peters, J. R., Poole, C., & Currie, C. J. (2006). Characterization and comparison of health-related utility in people with diabetes with various single and multiple vascular complications. Diabetic Medicine, 23(10), 1100–1105.PubMedCrossRef

47.

Sakamaki, H., Ikeda, S., Ikegami, N., Uchigata, Y., Iwamoto, Y., Origasa, H., et al. (2006). Measurement of HRQL using EQ-5D in patients with type 2 diabetes mellitus in Japan. Value in Health, 9(1), 47–53.PubMedCrossRef

48.

Supina, A. L., Feeny, D. H., Carroll, L. J., & Johnson, J. A. (2006). Misinterpretation with norm-based scoring of health status in adults with type 1 diabetes. Health and Quality of Life Outcomes, 16(4), 15.CrossRef

49.

Boye, K. S., Yurgin, N., Dilla, T., Cordero, L. A., Badia, X., Suriñach, N. L., et al. (2007). Health-related quality of life of patients with type 2 diabetes mellitus in primary care in Spain: self-reported and proxy assessment using the EQ-5D. Journal of Medical Economics, 10(1), 41–58.CrossRef

50.

Huang, E. S., Brown, S. E., Ewigman, B. G., Foley, E. C., & Meltzer, D. O. (2007). Patient perceptions of quality of life with diabetes-related complications and treatments. Diabetes Care, 30(10), 2478–2483.PubMedCrossRef

51.

Glasziou, P., Alexander, J., Beller, E., Clarke, P. M., & The ADVANCE Collaborative Group. (2007). Which health-related quality of life score? A comparison of alternative utility measures in patients with type 2 diabetes in the ADVANCE trial. Health and Quality of Life Outcomes, 27(5), 21.CrossRef

52.

Matza, L. S., Boye, K. S., Yurgin, N., Brewster-Jordan, J., Mannix, S., Shorr, J. M., et al. (2007). Utilities and disutilities for type 2 diabetes treatment-related attributes. Quality of Life Research, 16(7), 1251–1265.PubMedCrossRef

53.

Sullivan, P. W., Ghushchyan, V. H., & Ben-Joseph, R. (2008). The impact of obesity on diabetes, hyperlipidemia and hypertension in the United States. Quality of Life Research, 17(8), 1063–1071.PubMedCrossRef

54.

Vexiau, P., Mavros, P., Krishnarajah, G., Lyu, R., & Yin, D. (2008). Hypoglycaemia in patients with type 2 diabetes treated with a combination of metformin and sulphonylurea therapy in France. Diabetes, obesity and metabolism, 10(Suppl, 1), 16–24.PubMedCrossRef

55.

Arne, M., Janson, C., Janson, S., Boman, G., Lindqvist, U., Berne, C., et al. (2009). Physical activity and quality of life in subjects with chronic disease: Chronic obstructive pulmonary disease compared with rheumatoid arthritis and diabetes mellitus. Scandinavian Journal of Primary Health Care, 27(3), 141–147.PubMedCrossRef

56.

Clarke, P. M., Hayes, A. J., Glasziou, P. G., Scott, R., Simes, J., & Keech, A. C. (2009). Using the EQ-5D index score as a predictor of outcomes in patients with type 2 diabetes. Medical Care, 47(1), 61–68.PubMedCrossRef

57.

Marrett, E., Stargardt, T., Mavros, P., & Alexander, C. M. (2009). Patient-reported outcomes in a survey of patients treated with oral antihyperglycaemic medications: associations with hypoglycaemia and weight gain. Diabetes, obesity and metabolism, 11(12), 1138–1144.PubMedCrossRef

58.

Zhang, X. H., Wee, H. L., Tan, K., Thumboo, J., & Li, S. C. (2009). Is diabetes knowledge associated with health-related quality of life among subjects with diabetes? A preliminary cross-sectional convenience-sampling survey study among English-speaking diabetic subjects in Singapore. Journal of Chinese Clinical medicine, 4(3), 144–150.

59.

Mills, T., Law, S. K., Walt, J., Buchholz, P., & Hansen, J. (2009). Quality of Life in Glaucoma and Three Other Chronic Diseases. Drugs and Aging, 26(11), 933–950.PubMedCrossRef

60.

Imayama, I. (2009). Determinants of quality of life in adults with diabetes. Centre of Health Promotion Studies, School of Public Health. US: DPhil University of Alberta.

61.

Cochran, J., & Conn, V. S. (2008). Meta-analysis of quality of life outcomes following diabetes self-management training. The Diabetes Educator, 34(5), 815–823.PubMedCrossRef

62.

Kind, P., Hardman, G. & Macran Susan. (1999) UK population norms for EQ-5D: Discussion Paper 172 The University of York, Centre for Health Economics.

63.

Fryback, D. G., Dunham, N. C., Palta, M., Hammer, J., Buechner, J., Cherepanov, D., et al. (2007). US Norms for six generic health-related quality of life indexes from the national health measurement study. Medical Care, 45(12), 1162–1170.PubMedCrossRef

64.

Ariza-Ariza, R., Hernandez-Cruz, B., Carmona, L., Ruiz-Montesinos, M. D., Ballina, J., Navarro-Sarabia, F., et al. (2006). Assessing utility values in rheumatoid arthritis: A comparison between time trade off and the EuroQol. Arthritis Care & Research, 55(5), 751–756.CrossRef

65.

Ramon Luengo-Fernandez. (2009). Resource costs, health outcomes and cost effectiveness in stroke care: Evidence from the Oxford Vascular Study. DPhil, Oxford University, UK.

66.

Liem, Y. S., Bosch, J. L., & Hunink, M. G. (2008). Preference-Based quality of life of patients on renal replacement therapy: A systematic review and meta-analysis. Value in Health, 11(4), 733–741.PubMedCrossRef

67.

National Institute for Clinical Excellence (NICE) (2004), Guide to the methods of technology appraisal, NICE, London.

68.

Commonwealth of Australia. (1995). Guidelines for the pharmaceutical industry on preparation of submissions to the Pharmaceutical Benefits Advisory Committee: including economic analysis. Canberra: Department of Health and Community Services.

Titel: A meta-analysis of health state valuations for people with diabetes: explaining the variation across methods and implications for economic evaluation
verfasst von: Tom W. C. Lung
Alison J. Hayes
Andrew Hayen
Andrew Farmer
Philip M. Clarke
Publikationsdatum: 01.12.2011
Verlag: Springer Netherlands
Erschienen in: Quality of Life Research / Ausgabe 10/2011
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-011-9902-y

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

A meta-analysis of health state valuations for people with diabetes: explaining the variation across methods and implications for economic evaluation

Abstract

Purpose

Methods

Results

Conclusions

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 10/2011

Application of the Oral Health Impact Profile (OHIP) among Taiwanese elderly

Quality of life and emotional burden of primary caregivers: a case–control study of multiple sclerosis patients in Greece

Impact of nocturia on disease-specific quality of life for men with localized prostate cancer

Quality of life and physical limitations in primary brain tumor patients

Importance of patient satisfaction with care in predicting osteoarthritis-specific health-related quality of life one year after total joint arthroplasty

In prospective study using Specific Quality of Life & Outcomes Response-Venous (SQOR-V) questionnaire the recall bias had the same magnitude as the minimally important difference