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Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders 2/2018

05.09.2017 | Original Article

A meta-analytic review of the association between cortisol reactivity in response to a stressor and attention-deficit hyperactivity disorder

verfasst von: Jaclyn M. Kamradt, Allison M. Momany, Molly A. Nikolas

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 2/2018

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Abstract

A substantial literature suggests that abnormal cortisol reactivity may be a vulnerability for deleterious mental health outcomes, including ADHD. ADHD has been linked with difficulty in emotion regulation and increased risk of experiencing stressors, both of which may be related to psychobiological abnormalities (e.g., abnormal cortisol reactivity). Research has been mixed regarding the association between cortisol reactivity and ADHD. Therefore, the present meta-analytic review (k = 12) sought to quantify this association and review the relevant methodological issues and theoretical implications of this area of research. Overall, no effect was found between cortisol reactivity and ADHD (r = 0), although significant heterogeneity in the analyses suggested that there might be moderators of this association, if one does exist. Results highlight the importance of addressing limitations of the current literature on cortisol reactivity and ADHD and exploring additional indices of emotion regulation that may be associated with ADHD. Implications for future research efforts are discussed.
Literatur
Zurück zum Zitat Abelson JL, Curtis GC (1996) Hypothalamic–pituitary–adrenal axis activity in panic disorder: 24-hour secretion of corticotropin and cortisol. Arch Gen Psychiatry 53(4):323–331CrossRefPubMed Abelson JL, Curtis GC (1996) Hypothalamic–pituitary–adrenal axis activity in panic disorder: 24-hour secretion of corticotropin and cortisol. Arch Gen Psychiatry 53(4):323–331CrossRefPubMed
Zurück zum Zitat Alink LR, van Ijzendoorn MH, Bakermans-Kranenburg MJ, Mesman J, Juffer F, Koot HM (2008) Cortisol and externalizing behavior in children and adolescents: mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Dev Psychobiol 50(5):427–450. doi:10.1002/dev.20300 CrossRefPubMed Alink LR, van Ijzendoorn MH, Bakermans-Kranenburg MJ, Mesman J, Juffer F, Koot HM (2008) Cortisol and externalizing behavior in children and adolescents: mixed meta-analytic evidence for the inverse relation of basal cortisol and cortisol reactivity with externalizing behavior. Dev Psychobiol 50(5):427–450. doi:10.​1002/​dev.​20300 CrossRefPubMed
Zurück zum Zitat American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5®). American Psychiatric Pub
Zurück zum Zitat Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129CrossRef Cochran WG (1954) The combination of estimates from different experiments. Biometrics 10:101–129CrossRef
Zurück zum Zitat Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. L: Erlbaum, Hillsdale Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. L: Erlbaum, Hillsdale
Zurück zum Zitat Combs MA, Canu WH, Broman-Fulks JJ, Rocheleau CA, Nieman DC (2015) Perceived stress and ADHD symptoms in adults. J Atten Disord 19(5):425–434CrossRefPubMed Combs MA, Canu WH, Broman-Fulks JJ, Rocheleau CA, Nieman DC (2015) Perceived stress and ADHD symptoms in adults. J Atten Disord 19(5):425–434CrossRefPubMed
Zurück zum Zitat Corominas-Roso M, Palomar G, Ferrer R, Real A, Nogueira M, Corrales M et al (2015) Cortisol response to stress in adults with attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 18(9):pyv027CrossRefPubMedPubMedCentral Corominas-Roso M, Palomar G, Ferrer R, Real A, Nogueira M, Corrales M et al (2015) Cortisol response to stress in adults with attention deficit hyperactivity disorder. Int J Neuropsychopharmacol 18(9):pyv027CrossRefPubMedPubMedCentral
Zurück zum Zitat de Kloet ER (1991) Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol 12(2):95–164 de Kloet ER (1991) Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol 12(2):95–164
Zurück zum Zitat DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188CrossRefPubMed
Zurück zum Zitat Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455–463CrossRefPubMed Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455–463CrossRefPubMed
Zurück zum Zitat Goldstein L (1984) Lazarus RS, Folkman S. Stress, appraisal, and coping. Springer, New York Goldstein L (1984) Lazarus RS, Folkman S. Stress, appraisal, and coping. Springer, New York
Zurück zum Zitat Greaves-Lord K, Ferdinand RF, Oldehinkel AJ, Sondeijker FE, Ormel J, Verhulst FC (2007) Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatr Scand 116(2):137–144CrossRefPubMed Greaves-Lord K, Ferdinand RF, Oldehinkel AJ, Sondeijker FE, Ormel J, Verhulst FC (2007) Higher cortisol awakening response in young adolescents with persistent anxiety problems. Acta Psychiatr Scand 116(2):137–144CrossRefPubMed
Zurück zum Zitat Gross JJ (1998) The emerging field of emotion regulation: an integrative review. Rev Gen Psychol 2(3):271CrossRef Gross JJ (1998) The emerging field of emotion regulation: an integrative review. Rev Gen Psychol 2(3):271CrossRef
Zurück zum Zitat Hastings PD, Fortier I, Utendale WT, Simard LR, Robaey P (2009) Adrenocortical functioning in boys with attention-deficit/hyperactivity disorder: examining subtypes of ADHD and associated comorbid conditions. J Abnorm Child Psychol 37(4):565–578CrossRefPubMed Hastings PD, Fortier I, Utendale WT, Simard LR, Robaey P (2009) Adrenocortical functioning in boys with attention-deficit/hyperactivity disorder: examining subtypes of ADHD and associated comorbid conditions. J Abnorm Child Psychol 37(4):565–578CrossRefPubMed
Zurück zum Zitat Hirvikoski T, Lindholm T, Nordenström A, Nordström A-L, Lajic S (2009) High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder). Horm Behav 55(3):418–424CrossRefPubMed Hirvikoski T, Lindholm T, Nordenström A, Nordström A-L, Lajic S (2009) High self-perceived stress and many stressors, but normal diurnal cortisol rhythm, in adults with ADHD (attention-deficit/hyperactivity disorder). Horm Behav 55(3):418–424CrossRefPubMed
Zurück zum Zitat Jacob C, Gross-Lesch S, Jans T, Geissler J, Reif A, Dempfle A, Lesch KP (2014) Internalizing and externalizing behavior in adult ADHD. Atten Deficit Hyperact Disord 6(2):101–110. doi:10.1007/s12402-014-0128-z CrossRef Jacob C, Gross-Lesch S, Jans T, Geissler J, Reif A, Dempfle A, Lesch KP (2014) Internalizing and externalizing behavior in adult ADHD. Atten Deficit Hyperact Disord 6(2):101–110. doi:10.​1007/​s12402-014-0128-z CrossRef
Zurück zum Zitat Jimenez EAA, Ballabriga MCJ, Martin AB, Arrufat FJ, Giacobo RS (2013) Executive functioning in children and adolscents with symptoms of sluggish cognitive tempo and ADHD. J Atten Disord 19(6):507–514CrossRef Jimenez EAA, Ballabriga MCJ, Martin AB, Arrufat FJ, Giacobo RS (2013) Executive functioning in children and adolscents with symptoms of sluggish cognitive tempo and ADHD. J Atten Disord 19(6):507–514CrossRef
Zurück zum Zitat Kaneko M, Hoshino Y, Hashimoto S, Okano T, Kumashiro H (1993) Hypothalamic–pituitary–adrenal axis function in children with attention-deficit hyperactivity disorder. J Autism Dev Disord 23(1):59–65CrossRefPubMed Kaneko M, Hoshino Y, Hashimoto S, Okano T, Kumashiro H (1993) Hypothalamic–pituitary–adrenal axis function in children with attention-deficit hyperactivity disorder. J Autism Dev Disord 23(1):59–65CrossRefPubMed
Zurück zum Zitat Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O et al (2006) The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163(4):716–723CrossRefPubMedPubMedCentral Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O et al (2006) The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163(4):716–723CrossRefPubMedPubMedCentral
Zurück zum Zitat Lackschewitz H, Hüther G, Kröner-Herwig B (2008) Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrinology 33(5):612–624CrossRefPubMed Lackschewitz H, Hüther G, Kröner-Herwig B (2008) Physiological and psychological stress responses in adults with attention-deficit/hyperactivity disorder (ADHD). Psychoneuroendocrinology 33(5):612–624CrossRefPubMed
Zurück zum Zitat Lazarus RS, Folkman S (1984) Stress, appraisal, and coping. Springer, New York Lazarus RS, Folkman S (1984) Stress, appraisal, and coping. Springer, New York
Zurück zum Zitat Levine S, Smuts B (1977) Limbic system regulation of ACTH. Acta Physiol Pol 28(15):93PubMed Levine S, Smuts B (1977) Limbic system regulation of ACTH. Acta Physiol Pol 28(15):93PubMed
Zurück zum Zitat Lipsey MW, Wilson D (2001) Practical meta-analysis. Sage Publications Inc, Thousand Oaks Lipsey MW, Wilson D (2001) Practical meta-analysis. Sage Publications Inc, Thousand Oaks
Zurück zum Zitat Maldonado EF, Trianes MV, Cortés A, Moreno E, Escobar M (2009) Salivary cortisol response to a psychosocial stressor on children diagnosed with attention-deficit/hyperactivity disorder: differences between diagnostic subtypes. Span J Psychol 12(02):707–714CrossRefPubMed Maldonado EF, Trianes MV, Cortés A, Moreno E, Escobar M (2009) Salivary cortisol response to a psychosocial stressor on children diagnosed with attention-deficit/hyperactivity disorder: differences between diagnostic subtypes. Span J Psychol 12(02):707–714CrossRefPubMed
Zurück zum Zitat Mason JW (1975) A historical view of the stress field. J Hum Stress 1(2):22–36CrossRef Mason JW (1975) A historical view of the stress field. J Hum Stress 1(2):22–36CrossRef
Zurück zum Zitat Moreno SG, Sutton AJ, Ades AE, Stanley TD, Abrams KR, Peters JL, Cooper NJ (2009) Assessment of regression-based methods to adjust for publication bias through a comprehensive simulation study. BMC Med Res Methodol 9(1):2CrossRefPubMedPubMedCentral Moreno SG, Sutton AJ, Ades AE, Stanley TD, Abrams KR, Peters JL, Cooper NJ (2009) Assessment of regression-based methods to adjust for publication bias through a comprehensive simulation study. BMC Med Res Methodol 9(1):2CrossRefPubMedPubMedCentral
Zurück zum Zitat Morris MC, Rao U, Garber J (2012) Cortisol responses to psychosocial stress predict depression trajectories: social-evaluative threat and prior depressive episodes as moderators. J Affect Disord 143(1):223–230CrossRefPubMedPubMedCentral Morris MC, Rao U, Garber J (2012) Cortisol responses to psychosocial stress predict depression trajectories: social-evaluative threat and prior depressive episodes as moderators. J Affect Disord 143(1):223–230CrossRefPubMedPubMedCentral
Zurück zum Zitat Pesonen A-K, Kajantie E, Jones A, Pyhälä R, Lahti J, Heinonen K et al (2011) Symptoms of attention deficit hyperactivity disorder in children are associated with cortisol responses to psychosocial stress but not with daily cortisol levels. J Psychiatr Res 45(11):1471–1476CrossRefPubMed Pesonen A-K, Kajantie E, Jones A, Pyhälä R, Lahti J, Heinonen K et al (2011) Symptoms of attention deficit hyperactivity disorder in children are associated with cortisol responses to psychosocial stress but not with daily cortisol levels. J Psychiatr Res 45(11):1471–1476CrossRefPubMed
Zurück zum Zitat Raine A (1996) Autonomic nervous system factors underlying disinhibited, antisocial, and violent behavior. Biosocial perspectives and treatment implications. Ann N Y Acad Sci 794:46–59CrossRefPubMed Raine A (1996) Autonomic nervous system factors underlying disinhibited, antisocial, and violent behavior. Biosocial perspectives and treatment implications. Ann N Y Acad Sci 794:46–59CrossRefPubMed
Zurück zum Zitat Rothstein HR, Sutton AJ, Borenstein M (eds) (2006) Publication bias in meta-analysis: Prevention, assessment and adjustments. Wiley, England Rothstein HR, Sutton AJ, Borenstein M (eds) (2006) Publication bias in meta-analysis: Prevention, assessment and adjustments. Wiley, England
Zurück zum Zitat Stansbury K, Gunnar MR (1994) Adrenocortical activity and emotion regulation. Monogr Soc Res Child Dev 59(2–3):108–134CrossRefPubMed Stansbury K, Gunnar MR (1994) Adrenocortical activity and emotion regulation. Monogr Soc Res Child Dev 59(2–3):108–134CrossRefPubMed
Zurück zum Zitat Sterne JA, Egger M (2005) Regression methods to detect publication and other bias in meta-analysis. In: Publication bias in meta-analysis: Prevention, assessment and adjustments. Wiley, New York, pp 99–110 Sterne JA, Egger M (2005) Regression methods to detect publication and other bias in meta-analysis. In: Publication bias in meta-analysis: Prevention, assessment and adjustments. Wiley, New York, pp 99–110
Zurück zum Zitat Stewart JG, Mazurka R, Bond L, Wynne-Edwards KE, Harkness KL (2013) Rumination and impaired cortisol recovery following a social stressor in adolescent depression. J Abnorm Child Psychol 41(7):1015–1026CrossRefPubMed Stewart JG, Mazurka R, Bond L, Wynne-Edwards KE, Harkness KL (2013) Rumination and impaired cortisol recovery following a social stressor in adolescent depression. J Abnorm Child Psychol 41(7):1015–1026CrossRefPubMed
Zurück zum Zitat van West D, Claes S, Deboutte D (2009) Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types. Eur Child Adolesc Psychiatry 18(9):543–553. doi:10.1007/s00787-009-0011-1 CrossRefPubMed van West D, Claes S, Deboutte D (2009) Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types. Eur Child Adolesc Psychiatry 18(9):543–553. doi:10.​1007/​s00787-009-0011-1 CrossRefPubMed
Zurück zum Zitat Viechtbauer W (2010) Conducting meta-analyses in R with the metafor package. J Stat Softw 36(3):1–48CrossRef Viechtbauer W (2010) Conducting meta-analyses in R with the metafor package. J Stat Softw 36(3):1–48CrossRef
Zurück zum Zitat Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher TF, Hellman L (1971) Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 33(1):14–22. doi:10.1210/jcem-33-1-14 CrossRefPubMed Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher TF, Hellman L (1971) Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 33(1):14–22. doi:10.​1210/​jcem-33-1-14 CrossRefPubMed
Zurück zum Zitat Yehuda R (2002) Current status of cortisol findings in post-traumatic stress disorder. Psychiatr Clin N Am 25(2):341–368CrossRef Yehuda R (2002) Current status of cortisol findings in post-traumatic stress disorder. Psychiatr Clin N Am 25(2):341–368CrossRef
Metadaten
Titel
A meta-analytic review of the association between cortisol reactivity in response to a stressor and attention-deficit hyperactivity disorder
verfasst von
Jaclyn M. Kamradt
Allison M. Momany
Molly A. Nikolas
Publikationsdatum
05.09.2017
Verlag
Springer Vienna
Erschienen in
ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 2/2018
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI
https://doi.org/10.1007/s12402-017-0238-5

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