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06.01.2018 | Functional Neuroradiology

A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation

verfasst von: Erik H. Middlebrooks, Vanessa M. Holanda, Ibrahim S. Tuna, Hrishikesh D. Deshpande, Markus Bredel, Leonardo Almeida, Harrison C. Walker, Barton L. Guthrie, Kelly D. Foote, Michael S. Okun

Erschienen in: Neuroradiology | Ausgabe 3/2018

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Abstract

Purpose

Deep brain stimulation is a common treatment for medication-refractory essential tremor. Current coordinate-based targeting methods result in variable outcomes due to variation in thalamic structure and the optimal patient-specific functional location. The purpose of this study was to compare the coordinate-based pre-operative targets to patient-specific thalamic segmentation utilizing a probabilistic tractography methodology.

Methods

Using available diffusion MRI of 32 subjects from the Human Connectome Project database, probabilistic tractography was performed. Each thalamic voxel was coded based on one of six predefined cortical targets. The segmentation results were analyzed and compared to a 2-mm spherical target centered at the coordinate-based location of the ventral intermediate thalamic nucleus.

Results

The traditional coordinate-based target had maximal overlap with the junction of the region most connected to primary motor cortex (M1) (36.6 ± 25.7% of voxels on left; 58.1 ± 28.5% on right) and the area connected to the supplementary motor area/premotor cortex (SMA/PMC) (44.9 ± 21.7% of voxels on left; 28.9 ± 22.2% on right). There was a within-subject coefficient of variation from right-to-left of 69.4 and 63.1% in the volume of overlap with the SMA/PMC and M1 regions, respectively.

Conclusion

Thalamic segmentation based on structural connectivity measures is a promising technique that may enhance traditional targeting methods by generating reproducible, patient-specific pre-operative functional targets. Our results highlight the problematic intra- and inter-subject variability of indirect, coordinate-based targets. Future prospective clinical studies will be needed to validate this targeting methodology in essential tremor patients.

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Titel: A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation
verfasst von: Erik H. Middlebrooks
Vanessa M. Holanda
Ibrahim S. Tuna
Hrishikesh D. Deshpande
Markus Bredel
Leonardo Almeida
Harrison C. Walker
Barton L. Guthrie
Kelly D. Foote
Michael S. Okun
Publikationsdatum: 06.01.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Neuroradiology / Ausgabe 3/2018
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-017-1972-2

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A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

Purpose

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