Skip to main content
Erschienen in: Surgical Endoscopy 1/2018

29.06.2017 | New Technology

A modified endoscopic method for resection of gastric submucosal tumor

verfasst von: Qiang Zhang, Yue Li, Zhou-yang Lian, Zhen Wang, Li-hui Wang, Yang Bai, Si-de Liu

Erschienen in: Surgical Endoscopy | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Background and objective

Endoscopic mucosa-sparing lateral dissection (EMSLD) was developed by our group, and is used to remove gastric submucosal tumor (SMT). This study aims to evaluate the feasibility and safety of this method.

Methods

This retrospective study included 25 patients who underwent EMSLDs at an endoscopy center as a national key unit in china from October 2015 to July 2016. The main data collected were the size of the gastric SMT, its location and origin, en bloc resection rate, operating time, intraoperative and postoperative complications, hospitalization expense, hospital days, and follow-up after hospital discharge.

Results

The mean (SD) size of the gastric SMTs was 18.3 (5.9) mm; 96% (24/25) of the tumors originated in the muscularis propria; and 64% (16/25) and 28% (7/25) were located in the gastric fundus and gastric body, respectively. The rate of en bloc resection was 96% (24/25), and the rate of intraoperative perforations due to endoscopic full-thickness resection was 48% (12/25). All wounds and perforations were effectively closed using endoscopic clips combined with the retained mucosa. The mean operative time was 74.2 (38.0) min. Delayed bleeding and perforation were not observed.

Conclusion

Endoscopic mucosa-sparing lateral dissection is safe and feasible for the removal of gastric SMTs. The wound can be effectively closed using the retained mucosa and endoscopic clips, even if perforation has occurred. EMSLD provides an alternative to the resection of gastric SMTs, especially for tumors with a risk of intraoperative perforation.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Joo MK, Park JJ, Kim H, Koh JS, Lee BJ, Chun HJ, Lee SW, Jang YJ, Mok YJ, Bak YT (2016) Endoscopic versus surgical resection of GI stromal tumors in the upper GI tract. Gastrointest Endosc 83:318–326CrossRefPubMed Joo MK, Park JJ, Kim H, Koh JS, Lee BJ, Chun HJ, Lee SW, Jang YJ, Mok YJ, Bak YT (2016) Endoscopic versus surgical resection of GI stromal tumors in the upper GI tract. Gastrointest Endosc 83:318–326CrossRefPubMed
2.
Zurück zum Zitat Ye LP, Zhang Y, Luo DH, Mao XL, Zheng HH, Zhou XB, Zhu LH (2016) Safety of endoscopic resection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer: an analysis of 733 tumors. Am J Gastroenterol 111:788–796CrossRefPubMed Ye LP, Zhang Y, Luo DH, Mao XL, Zheng HH, Zhou XB, Zhu LH (2016) Safety of endoscopic resection for upper gastrointestinal subepithelial tumors originating from the muscularis propria layer: an analysis of 733 tumors. Am J Gastroenterol 111:788–796CrossRefPubMed
3.
Zurück zum Zitat Rogalski P, Daniluk J, Baniukiewicz A, Wroblewski E, Dabrowski A (2015) Endoscopic management of gastrointestinal perforations, leaks and fistulas. World J Gastroenterol 21:10542–10552CrossRefPubMedPubMedCentral Rogalski P, Daniluk J, Baniukiewicz A, Wroblewski E, Dabrowski A (2015) Endoscopic management of gastrointestinal perforations, leaks and fistulas. World J Gastroenterol 21:10542–10552CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Li QL, Chen WF, Zhang C, Hu JW, Zhou PH, Zhang YQ, Zhong YS, Yao LQ, Xu MD (2015) Clinical impact of submucosal tunneling endoscopic resection for the treatment of gastric submucosal tumors originating from the muscularis propria layer (with video). Surg Endosc 29:3640–3646CrossRefPubMed Li QL, Chen WF, Zhang C, Hu JW, Zhou PH, Zhang YQ, Zhong YS, Yao LQ, Xu MD (2015) Clinical impact of submucosal tunneling endoscopic resection for the treatment of gastric submucosal tumors originating from the muscularis propria layer (with video). Surg Endosc 29:3640–3646CrossRefPubMed
5.
Zurück zum Zitat Zhang Q, Li Y, Meng Y, Bai Y, Cai JQ, Han ZL, Wang Z, Zhi FC, Liu SD (2016) Should the integrity of mucosa be considered in endoscopic resection of gastric submucosal tumors ? Gastroenterology 150(822–4):e9 Zhang Q, Li Y, Meng Y, Bai Y, Cai JQ, Han ZL, Wang Z, Zhi FC, Liu SD (2016) Should the integrity of mucosa be considered in endoscopic resection of gastric submucosal tumors ? Gastroenterology 150(822–4):e9
6.
Zurück zum Zitat Otake Y, Saito Y, Sakamoto T, Aoki T, Nakajima T, Toyoshima N, Matsuda T, Ono H (2012) New closure technique for large mucosal defects after endoscopic submucosal dissection of colorectal tumors (with video). Gastrointest Endosc 75:663–667CrossRefPubMed Otake Y, Saito Y, Sakamoto T, Aoki T, Nakajima T, Toyoshima N, Matsuda T, Ono H (2012) New closure technique for large mucosal defects after endoscopic submucosal dissection of colorectal tumors (with video). Gastrointest Endosc 75:663–667CrossRefPubMed
7.
Zurück zum Zitat Nishida T, Blay JY, Hirota S, Kitagawa Y, Kang YK (2016) The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines. Gastric Cancer 19:3–14CrossRefPubMed Nishida T, Blay JY, Hirota S, Kitagawa Y, Kang YK (2016) The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines. Gastric Cancer 19:3–14CrossRefPubMed
8.
Zurück zum Zitat Hwang JH, Rulyak SD, Kimmey MB, American Gastroenterological Association Institute (2006) American Gastroenterological Association Institute technical review on the management of gastric subepithelial masses. Gastroenterology 130:2217–2228CrossRefPubMed Hwang JH, Rulyak SD, Kimmey MB, American Gastroenterological Association Institute (2006) American Gastroenterological Association Institute technical review on the management of gastric subepithelial masses. Gastroenterology 130:2217–2228CrossRefPubMed
9.
Zurück zum Zitat Kushnir VM, Keswani RN, Hollander TG, Kohlmeier C, Mullady DK, Azar RR, Murad FM, Komanduri S, Edmundowicz SA, Early DS (2015) Compliance with surveillance recommendations for foregut subepithelial tumors is poor: results of a prospective multicenter study. Gastrointest Endosc 81:1378–1384CrossRefPubMed Kushnir VM, Keswani RN, Hollander TG, Kohlmeier C, Mullady DK, Azar RR, Murad FM, Komanduri S, Edmundowicz SA, Early DS (2015) Compliance with surveillance recommendations for foregut subepithelial tumors is poor: results of a prospective multicenter study. Gastrointest Endosc 81:1378–1384CrossRefPubMed
10.
Zurück zum Zitat Catalano F, Rodella L, Lombardo F, Silano M, Tomezzoli A, Fuini A, Di Cosmo MA, de Manzoni G, Trecca A (2013) Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study. Gastric Cancer 16:563–570CrossRefPubMed Catalano F, Rodella L, Lombardo F, Silano M, Tomezzoli A, Fuini A, Di Cosmo MA, de Manzoni G, Trecca A (2013) Endoscopic submucosal dissection in the treatment of gastric submucosal tumors: results from a retrospective cohort study. Gastric Cancer 16:563–570CrossRefPubMed
11.
Zurück zum Zitat Białek A, Wiechowska-Kozłowska A, Pertkiewicz J, Polkowski M, Milkiewicz P, Karpińska K, Ławniczak M, Starzyńska T (2012) Endoscopic submucosal dissection for treatment of gastric subepithelial tumors (with video). Gastrointest Endosc 75:276–286CrossRefPubMed Białek A, Wiechowska-Kozłowska A, Pertkiewicz J, Polkowski M, Milkiewicz P, Karpińska K, Ławniczak M, Starzyńska T (2012) Endoscopic submucosal dissection for treatment of gastric subepithelial tumors (with video). Gastrointest Endosc 75:276–286CrossRefPubMed
12.
Zurück zum Zitat Chu YY, Lien JM, Tsai MH, Chiu CT, Chen TC, Yang KC, Ng SC (2012) Modified endoscopic submucosal dissection with enucleation for treatment of gastric subepithelial tumors originating from the muscularis propria layer. BMC Gastroenterol 12:124CrossRefPubMedPubMedCentral Chu YY, Lien JM, Tsai MH, Chiu CT, Chen TC, Yang KC, Ng SC (2012) Modified endoscopic submucosal dissection with enucleation for treatment of gastric subepithelial tumors originating from the muscularis propria layer. BMC Gastroenterol 12:124CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Huang LY, Cui J, Liu YX, Wu CR, Yi DL (2012) Endoscopic therapy for gastric stromal tumors originating from the muscularis propria. World J Gastroenterol 18:3465–3471CrossRefPubMedPubMedCentral Huang LY, Cui J, Liu YX, Wu CR, Yi DL (2012) Endoscopic therapy for gastric stromal tumors originating from the muscularis propria. World J Gastroenterol 18:3465–3471CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Jeong IH, Kim JH, Lee SR, Kim JH, Hwang JC, Shin SJ, Lee KM, Hur H, Han SU (2012) Minimally invasive treatment of gastric gastrointestinal stromal tumors: laparoscopic and endoscopic approach. Surg Laparosc Endosc Percutan Tech 22:244–250CrossRefPubMed Jeong IH, Kim JH, Lee SR, Kim JH, Hwang JC, Shin SJ, Lee KM, Hur H, Han SU (2012) Minimally invasive treatment of gastric gastrointestinal stromal tumors: laparoscopic and endoscopic approach. Surg Laparosc Endosc Percutan Tech 22:244–250CrossRefPubMed
15.
Zurück zum Zitat Zhang S, Chao GQ, Li M, Ni GB, Lv B (2013) Endoscopic submucosal dissection for treatment of gastric submucosal tumors originating from the muscularis propria layer. Dig Dis Sci 58:1710–1716CrossRefPubMed Zhang S, Chao GQ, Li M, Ni GB, Lv B (2013) Endoscopic submucosal dissection for treatment of gastric submucosal tumors originating from the muscularis propria layer. Dig Dis Sci 58:1710–1716CrossRefPubMed
16.
Zurück zum Zitat He Z, Sun C, Wang J, Zheng Z, Yu Q, Wang T, Chen X, Liu W, Wang B (2013) Efficacy and safety of endoscopic submucosal dissection in treating gastric subepithelial tumors originating in the muscularis propria layer: a single-center study of 144 cases. Scand J Gastroenterol 48:1466–1473CrossRefPubMed He Z, Sun C, Wang J, Zheng Z, Yu Q, Wang T, Chen X, Liu W, Wang B (2013) Efficacy and safety of endoscopic submucosal dissection in treating gastric subepithelial tumors originating in the muscularis propria layer: a single-center study of 144 cases. Scand J Gastroenterol 48:1466–1473CrossRefPubMed
17.
Zurück zum Zitat Li L, Wang F, Wu B, Wang Q, Wang C, Liu J (2013) Endoscopic submucosal dissection of gastric fundus subepithelial tumors originating from the muscularis propria. Exp Ther Med 6:391–395CrossRefPubMedPubMedCentral Li L, Wang F, Wu B, Wang Q, Wang C, Liu J (2013) Endoscopic submucosal dissection of gastric fundus subepithelial tumors originating from the muscularis propria. Exp Ther Med 6:391–395CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Zhou PH, Yao LQ, Qin XY, Cai MY, Xu MD, Zhong YS, Chen WF, Zhang YQ, Qin WZ, Hu JW, Liu JZ (2011) Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors originated from the muscularis propria. Surg Endosc 25:2926–2931CrossRefPubMed Zhou PH, Yao LQ, Qin XY, Cai MY, Xu MD, Zhong YS, Chen WF, Zhang YQ, Qin WZ, Hu JW, Liu JZ (2011) Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors originated from the muscularis propria. Surg Endosc 25:2926–2931CrossRefPubMed
19.
Zurück zum Zitat Yang F, Wang S, Sun S, Liu X, Ge N, Wang G, Guo J, Liu W, Feng L, Ma W (2015) Factors associated with endoscopic full-thickness resection of gastric submucosal tumors. Surg Endosc 29:3588–3593CrossRefPubMedPubMedCentral Yang F, Wang S, Sun S, Liu X, Ge N, Wang G, Guo J, Liu W, Feng L, Ma W (2015) Factors associated with endoscopic full-thickness resection of gastric submucosal tumors. Surg Endosc 29:3588–3593CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Feng Y, Yu L, Yang S, Li X, Ding J, Chen L, Xu Y, Shi R (2014) Endolumenal endoscopic full-thickness resection of muscularis propria-originating gastric submucosal tumors. J Laparoendosc Adv Surg Tech A 24:171–176CrossRefPubMed Feng Y, Yu L, Yang S, Li X, Ding J, Chen L, Xu Y, Shi R (2014) Endolumenal endoscopic full-thickness resection of muscularis propria-originating gastric submucosal tumors. J Laparoendosc Adv Surg Tech A 24:171–176CrossRefPubMed
21.
Zurück zum Zitat Mori H, Kobara H, Fujihara S, Nishiyama N, Ayagi M, Matsunaga T, Yachida T, Masaki T (2015) Establishment of the hybrid endoscopic full-thickness resection of gastric gastrointestinal stromal tumors. Mol Clin Oncol 3:18–22CrossRefPubMed Mori H, Kobara H, Fujihara S, Nishiyama N, Ayagi M, Matsunaga T, Yachida T, Masaki T (2015) Establishment of the hybrid endoscopic full-thickness resection of gastric gastrointestinal stromal tumors. Mol Clin Oncol 3:18–22CrossRefPubMed
22.
Zurück zum Zitat Lu J, Zheng M, Jiao T, Wang Y, Lu X (2014) Transcardiac tunneling technique for endoscopic submucosal dissection of gastric fundus tumors arising from the muscularis propria. Endoscopy 46:888–892CrossRefPubMed Lu J, Zheng M, Jiao T, Wang Y, Lu X (2014) Transcardiac tunneling technique for endoscopic submucosal dissection of gastric fundus tumors arising from the muscularis propria. Endoscopy 46:888–892CrossRefPubMed
23.
Zurück zum Zitat Verlaan T, Voermans RP, van Berge Henegouwen MI, Bemelman WA, Fockens P (2015) Endoscopic closure of acute perforations of the GI tract: a systematic review of the literature. Gastrointest Endosc 82(618–28):e5 Verlaan T, Voermans RP, van Berge Henegouwen MI, Bemelman WA, Fockens P (2015) Endoscopic closure of acute perforations of the GI tract: a systematic review of the literature. Gastrointest Endosc 82(618–28):e5
Metadaten
Titel
A modified endoscopic method for resection of gastric submucosal tumor
verfasst von
Qiang Zhang
Yue Li
Zhou-yang Lian
Zhen Wang
Li-hui Wang
Yang Bai
Si-de Liu
Publikationsdatum
29.06.2017
Verlag
Springer US
Erschienen in
Surgical Endoscopy / Ausgabe 1/2018
Print ISSN: 0930-2794
Elektronische ISSN: 1432-2218
DOI
https://doi.org/10.1007/s00464-017-5704-9

Weitere Artikel der Ausgabe 1/2018

Surgical Endoscopy 1/2018 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.