Background
Methods
Study cohort
Outcomes and variables
Inclusion and exclusion criteria
Statistical analyses
Results
Patient characteristics
Without Metastasis | Metastasis |
P
| |
---|---|---|---|
N = 1679 | N = 987 | ||
Age (years) | 0.221b | ||
≤ 60 | 793 (47.2%) | 442 (44.8%) | |
> 60 | 886 (52.8%) | 545 (55.2%) | |
Sex | 0.338a | ||
Male | 924 (55.0%) | 562 (56.9%) | |
Female | 755 (45.0%) | 425 (43.1%) | |
Race | 0.011a | ||
White | 1314 (78.3%) | 787 (79.7%) | |
Black | 191 (11.4%) | 130 (13.2%) | |
Other | 174 (10.3%) | 70 (7.1%) | |
Size (cm) | < 0.001b | ||
≤ 2 | 670 (39.9%) | 68 (6.9%) | |
> 2 | 934 (55.6%) | 699 (70.8%) | |
Unclear | 75 (4.5%) | 220 (22.3%) | |
Primary Site | < 0.001b | ||
Head | 502 (29.9%) | 258 (26.2%) | |
Body | 295 (17.6%) | 106 (10.7%) | |
Tail | 542 (32.3%) | 314 (31.8%) | |
Other | 340 (20.2%) | 309 (31.3%) | |
Differentiation | < 0.001b | ||
Well | 1043 (62.1%) | 189 (19.1%) | |
Moderately | 221 (13.2%) | 86 (8.7%) | |
Poorly | 64 (3.8%) | 95 (9.6%) | |
Undifferentiated | 17 (1.0%) | 28 (2.8%) | |
Unclear | 334 (19.9%) | 589 (59.7%) | |
T-sage | < 0.001b | ||
T1 | 602 (35.9%) | 37 (3.7%) | |
T2 | 538 (32.0%) | 276 (28.0%) | |
T3 | 389 (23.2%) | 271 (27.5%) | |
T4 | 67 (4.0%) | 102 (10.3%) | |
Tx | 83 (4.9%) | 301 (30.5%) | |
N-stage | < 0.001b | ||
N0 | 1247 (74.3%) | 463 (46.9%) | |
N1 | 401 (23.9%) | 338 (34.3%) | |
Nx | 31 (1.8%) | 186 (18.8%) | |
Surgery | < 0.001b | ||
Yes | 1313 (78.2%) | 164 (16.6%) | |
No | 339 (20.2%) | 813 (82.4%) | |
Unclear | 27 (1.6%) | 10 (1.0%) | |
Radiation | < 0.001b | ||
Yes | 52 (3.1%) | 74 (7.5%) | |
No | 1609 (95.8%) | 905 (91.7%) | |
Unclear | 18 (1.1%) | 8 (0.8%) |
Metastatic patterns and survival
Modified M-stage classification and discriminatory capability
AJCC and ENTES M-stage classifications | Modified M-stage classifications |
---|---|
M0-stage, no distant metastasis M1-stage, distant metastasis | mM0-stage, no distant metastasis mM1-stage, only liver metastasis mM2-stage, other single distant organ or two organs metastases mM3-stage, three or more organs metastases |
Univariate | Multivariate | |||
---|---|---|---|---|
HR and 95% CI | P-value | HR and 95% CI | P-value | |
Age (years) | ||||
≤ 60 | Reference | Reference | ||
> 60 | 1.875 (1.595–2.204) | < 0.001 | 1.744 (1.479–2.055) | < 0.001 |
Sex | ||||
Male | Reference | Reference | ||
Female | 0.808 (0.691–0.945) | 0.008 | 0.850 (0.726–0.996) | 0.044 |
Race | ||||
White | Reference | Reference | ||
Black | 1.345 (1.082–1.670) | 0.007 | 1.247 (0.998–1.558) | 0.052 |
Other | 0.715 (0.527–0.970) | 0.031 | 0.767 (0.565–1.043) | 0.090 |
Size (cm) | ||||
≤ 2 | Reference | Reference | ||
> 2 | 2.889 (2.241–3.724) | < 0.001 | 1.322 (1.009–1.731) | 0.043 |
Unclear | 6.799(5.110–9.047) | < 0.001 | 1.547(1.129–2.119) | 0.007 |
Primary Site | a | |||
Head | Reference | |||
Body | 0.684(0.530–0.884) | 0.004 | ||
Tail | 0.682(0.556–0.836) | < 0.001 | ||
Other | 1.128(0.929–1.368) | 0.223 | ||
Differentiation | ||||
Well | Reference | Reference | ||
Moderately | 1.557 (1.095–2.215) | 0.014 | 1.049 (0.735–1.498) | 0.791 |
Poorly | 7.414 (5.608–9.803) | < 0.001 | 3.349 (2.498–4.489) | < 0.001 |
Undifferentiated | 9.494 (6.113–14.743) | < 0.001 | 3.166 (2.000–5.011) | < 0.001 |
Unclear | 5.136 (4.179–6.311) | < 0.001 | 1.626 (1.290–2.048) | < 0.001 |
T-stage | a | |||
T1 | Reference | |||
T2 | 3.434(2.474–4.766) | < 0.001 | ||
T3 | 3.353(2.399–4.688) | < 0.001 | ||
T4 | 7.082(4.867–10.306) | < 0.001 | ||
Tx | 9.288(6.696–12.882) | < 0.001 | ||
N-stage | ||||
N0 | Reference | Reference | ||
N1 | 1.679 (1.415–1.993) | < 0.001 | 1.304 (1.092–1.557) | 0.003 |
Nx | 3.732 (3.019–4.613) | < 0.001 | 1.452 (1.152–1.829) | 0.002 |
Surgery | ||||
Yes | Reference | Reference | ||
No | 8.556 (6.941–10.548) | < 0.001 | 3.901 (3.013–5.050) | < 0.001 |
Unclear | 1.991 (0.812–4.883) | 0.133 | 1.487 (0.601–3.680) | 0.391 |
Radiation | a | |||
Yes | Reference | |||
No | 1.984(1.511–2.603) | < 0.001 | ||
Unclear | 0.939(0.420–2.098) | 0.878 | ||
mM-stage | ||||
mM0-stage | Reference | Reference | ||
mM1-stage | 4.520 (3.789–5.393) | < 0.001 | 1.643 (1.339–2.016) | < 0.001 |
mM2-stage | 8.199(6.380–10.537) | < 0.001 | 2.249(1.704–2.968) | < 0.001 |
mM3-stage | 16.356 (10.266–26.059) | < 0.001 | 5.034 (3.110–8.150) | < 0.001 |