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01.12.2012 | Research | Ausgabe 1/2012 Open Access

Cardiovascular Ultrasound 1/2012

A modified regimen of extracorporeal cardiac shock wave therapy for treatment of coronary artery disease

Zeitschrift:
Cardiovascular Ultrasound > Ausgabe 1/2012
Autoren:
Yu Wang, Tao Guo, Tie-kun Ma, Hong-yan Cai, Si-ming Tao, Yun-zhu Peng, Ping Yang, Ming-qing Chen, Yun Gu
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1476-7120-10-35) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare no conflict of interest.

Authors’ contributions

We declare that all the listed authors have participated actively in the study and all meet the requirements of the authorship. Dr. Tao Guo , Ming-Qing Chen, Yun Gu designed the study and wrote the protocol, Dr. Yu Wang, Hong-Yan Cai, Si-Ming Tao, Yun-Zhu Peng, Ping Yang performed research/study, Dr. Tie-Kun Ma, Hong-Yan Cai contributed important reagents, Dr. Yu Wang, Tao Guo managed the literature searches and analyses, Dr. Yu Wang,Si-Ming Tao undertook the statistical analysis, Dr. Yu Wang wrote the first draft of the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Cardiac shock wave therapy (CSWT) improves cardiac function in patients with severe coronary artery disease (CAD). We aimed to evaluate the clinical outcomes of a new CSWT treatment regimen.

Methods

The 55 patients with severe CAD were randomly divided into 3 treatment groups. The control group (n = 14) received only medical therapy. In group A ( n = 20), CSWT was performed 3 times within 3 months. In group B ( n = 21), patients underwent 3 CSWT sessions/week, and 9 treatment sessions were completed within 1 month. Primary outcome measurement was 6-minute walk test (6MWT). Other measurements were also evaluated.

Results

The 6MWT, CCS grading of angina, dosage of nitroglycerin, NYHA classification, and SAQ scores were improved in group A and B compared to control group.

Conclusions

A CSWT protocol with 1 month treatment duration showed similar therapeutic efficacy compared to a protocol of 3 months duration.

Clinical trial registry

We have registered on ClinicalTrials.gov, the protocol ID is CSWT IN CHINA.
Zusatzmaterial
Additional file 1:Table S1. Comparison of treadmill exercise test for control, 3 month and 1 month CSWT patients.(DOC 36 KB)
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Authors’ original file for figure 1
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Authors’ original file for figure 2
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Authors’ original file for figure 3
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Literatur
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