Background
Psychological resilience
Methods and design
Purpose
Scientific approach
Study population
Data sources
Data specific for SCAN-B Resilience
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At diagnosis | At one-year follow up | |
At diagnosis | At one-year follow up | |
CRF diagnosis | At diagnosis | At one-year follow up |
CRF follow-up | – | At one-year follow up |
Clinical serology data | At diagnosis • Inflammation markers (e.g., IL8, IL6, CRP) • Stress hormones, such as cortisol, etc. | – |
Data available from SCAN-B
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Patient Chart | ||
To complement missing data from the registry | ||
Data extraction of parameters available in INCA
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Menstrual status | ||
Diagnostics | Localization | |
Date of visit at clinic | ||
Date for suspicion of disease | ||
Date of diagnosis | ||
Screening discovery (Y/N) | ||
Determined malignancy before surgery | ||
Mammographic report | Date/Grade/Size | |
TNM classification | ||
Neoadjuvant treatment | ||
Surgery | Date | |
End result and complications | ||
Type of breast surgery | Mastectomy/Partial mastectomy | |
Morphology | ||
Tumor biology | ||
Postoperative evaluation | ||
Postoperative treatment | Systemic treatment | |
Radiotherapy | ||
Targeted therapy | ||
Data from the National Board of Health and Welfare
| ||
Antibiotics | ||
Hormone treatment | ||
Inpatient care | ||
Outpatient care | ||
Cause of death register |
Time plan
Methods
Bio-psychosocial assessment
Biomolecular analyses
Clinical serology
RNA-seq and tumor phenotyping
Inclusion criteria
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Newly diagnosed patients with primary breast cancer.
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Patients consented to be included in the SCAN-B study at (Blekinge County Hospital, Central Hospital Växjö, Hallands Hospital Halmstad and Helsingborg Hospital.
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Oral and written consent for the SCAN-B Resilience study.
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Age ≥ 18 years.
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Patients who understand the Swedish language (written and spoken).
Exclusion criteria
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No diagnosis of breast cancer.
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Not consented to be included in the SCAN-B study.
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Do not understand the Swedish language.
Data management
Outcomes
Primary outcome
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the association between psychological resilience and biomolecular signatures in breast cancer patients.
Secondary outcomes
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the association between psychological resilience and quality of life at baseline in breast cancer patients.
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the association between psychological resilience and quality of life one year after diagnosis in breast cancer patients.
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the association between psychological resilience and prognosis in breast cancer patients.
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the association between psychological resilience and clinicopathological characteristics.
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the association between quality of life and clinicopathological characteristics.
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the association between healthcare quality and psychological resilience in breast cancer patients.
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the association between healthcare quality and quality of life one year after diagnosis in breast cancer patients.
Power calculation
Effect size | Confidence | No. of required samples for 80% power |
---|---|---|
0.70 | 0.95 | 64 |
0.70 | 0.99 | 95 |
0.75 | 0.95 | 40 |
0.75 | 0.99 | 60 |