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Erschienen in: Inflammopharmacology 6/2023

16.10.2023 | Review

A narrative review of the effects of dexamethasone on traumatic brain injury in clinical and animal studies: focusing on inflammation

verfasst von: Afsaneh Soltani, Uliana Y. Chugaeva, Montather F. Ramadan, Ebraheem Abdu Musad Saleh, Shaker Shanawa Al-Hasnawi, Rosario Mireya Romero-Parra, Ali Alsaalamy, Yasser Fakri Mustafa, Mohammad Yasin Zamanian, Maryam Golmohammadi

Erschienen in: Inflammopharmacology | Ausgabe 6/2023

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Abstract

Traumatic brain injury (TBI) is a type of brain injury resulting from a sudden physical force to the head. TBI can range from mild, such as a concussion, to severe, which might result in long-term complications or even death. The initial impact or primary injury to the brain is followed by neuroinflammation, excitotoxicity, and oxidative stress, which are the hallmarks of the secondary injury phase, that can further damage the brain tissue. Dexamethasone (DXM) has neuroprotective effects. It reduces neuroinflammation, a critical factor in secondary injury-associated neuronal damage. DXM can also suppress the microglia activation and infiltrated macrophages, which are responsible for producing pro-inflammatory cytokines that contribute to neuroinflammation. Considering the outcomes of this research, some of the effects of DXM on TBI include: (1) DXM-loaded hydrogels reduce apoptosis, neuroinflammation, and lesion volume and improves neuronal cell survival and motor performance, (2) DXM treatment elevates the levels of Ndufs2, Gria3, MAOB, and Ndufv2 in the hippocampus following TBI, (3) DXM decreases the quantity of circulating endothelial progenitor cells, (4) DXM reduces the expression of IL1, (5) DXM suppresses the infiltration of RhoA + cells into primary lesions of TBI and (6) DXM treatment led to an increase in fractional anisotropy values and a decrease in apparent diffusion coefficient values, indicating improved white matter integrity. According to the study, the findings show that DXM treatment has neuroprotective effects in TBI. This indicates that DXM is a promising therapeutic approach to treating TBI.
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Metadaten
Titel
A narrative review of the effects of dexamethasone on traumatic brain injury in clinical and animal studies: focusing on inflammation
verfasst von
Afsaneh Soltani
Uliana Y. Chugaeva
Montather F. Ramadan
Ebraheem Abdu Musad Saleh
Shaker Shanawa Al-Hasnawi
Rosario Mireya Romero-Parra
Ali Alsaalamy
Yasser Fakri Mustafa
Mohammad Yasin Zamanian
Maryam Golmohammadi
Publikationsdatum
16.10.2023
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 6/2023
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-023-01361-3

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