A new risk stratification model for intravesical recurrence, disease progression, and cancer-specific death in patients with non-muscle invasive bladder cancer: the J-NICE risk tables
- 30.03.2020
- Original Article
Erschienen in:
- Verfasst von
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Makito Miyake
Makito Miyake
- Department of Urology, Nara Medical University, 634-8522, Kashihara, Japan
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Hideyasu Matsuyama
Hideyasu Matsuyama
- Department of Urology, Graduate School of Medicine, Yamaguchi University, 755-8505, Ube, Japan
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Satoshi Teramukai
Satoshi Teramukai
- Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan
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Fumie Kinoshita
Fumie Kinoshita
- Department of Biostatistics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 602-8566, Kyoto, Japan
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Isao Yokota
Isao Yokota
- Department of Biostatistics, Graduate of Medicine, Hokkaido University, 060-8638, Sapporo, Japan
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Hiroaki Matsumoto
Hiroaki Matsumoto
- Department of Urology, Graduate School of Medicine, Yamaguchi University, 755-8505, Ube, Japan
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Keiji Shimada
Keiji Shimada
- Department of Pathology, Nara City Hospital, 630-8305, Nara, Japan
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Mitsuru Kinjyo
Mitsuru Kinjyo
- Department of Pathology, Steel Memorial Yawata Hospital, 805-0050, Fukuoka, Japan
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Tatsuro Shimokama
Tatsuro Shimokama
- Department of Pathology, Steel Memorial Yawata Hospital, 805-0050, Fukuoka, Japan
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Koji Okumura
Koji Okumura
- Department of Urology, Steel Memorial Yawata Hospital, 805-0050, Fukuoka, Japan
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Masaya Yomenori
Masaya Yomenori
- Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 890-8520, Kagoshima, Japan
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Hideki Enokida
Hideki Enokida
- Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 890-8520, Kagoshima, Japan
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Masayuki Nakagawa
Masayuki Nakagawa
- Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 890-8520, Kagoshima, Japan
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Yasushi Nakai
Yasushi Nakai
- Department of Urology, Nara Medical University, 634-8522, Kashihara, Japan
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Kiyohide Fujimoto
Korrespondierender Autor Kiyohide Fujimoto
- Department of Urology, Nara Medical University, 634-8522, Kashihara, Japan
- Nishinihon Uro-oncology Extensive Collaboration group
- Erschienen in
- International Journal of Clinical Oncology | Ausgabe 7/2020
Abstract
Background
The aim of this study is to establish new risk tables for the current clinical setting, enabling short- and long-term risk stratification for recurrence, progression, and cancer-specific death after transurethral resection in non-muscle invasive bladder cancer (NMIBC). Currently available risk tables lack input from the 2004 World Health Organization grading system and risk prediction for cancer-specific death.
Methods
This was a multi-institutional database study of 1490 patients diagnosed with NMIBC (the development cohort). A multivariate Fine and Gray subdistribution hazard model was used to assess the prognostic impact of various factors. Patients were classified into low-, intermediate-, and high-risk groups according to a sum of the weight of selected factors, and predicted cumulative rates were calculated. Internal validation was conducted using 200 bootstrap resamples to assess the optimism for the c-index and estimate a bias-corrected c-index. External validation of the developed risk table was performed on an independent dataset of 91 patients.
Results
The Japanese NIshinihon uro-onCology Extensive collaboration group (J-NICE) risk stratification table was derived from six, five, and two factors for recurrence, progression, and cancer-specific death, respectively. The internal validation bias-corrected c-index values were 0.619, 0.621, and 0.705, respectively. The application of the J-NICE table to an external dataset resulted in c-indices for recurrence, progression, and cancer-specific death of 0.527, 0.691, and 0.603, respectively.
Conclusions
We propose a novel risk stratification model that predicts outcomes of treated NMIBC and may overcome the shortcomings of existing risk models. Further external validation is required to strengthen its clinical impact.
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- Titel
- A new risk stratification model for intravesical recurrence, disease progression, and cancer-specific death in patients with non-muscle invasive bladder cancer: the J-NICE risk tables
- Verfasst von
-
Makito Miyake
Hideyasu Matsuyama
Satoshi Teramukai
Fumie Kinoshita
Isao Yokota
Hiroaki Matsumoto
Keiji Shimada
Mitsuru Kinjyo
Tatsuro Shimokama
Koji Okumura
Masaya Yomenori
Hideki Enokida
Masayuki Nakagawa
Yasushi Nakai
Kiyohide Fujimoto
Nishinihon Uro-oncology Extensive Collaboration group
- Publikationsdatum
- 30.03.2020
- Verlag
- Springer Singapore
- Erschienen in
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International Journal of Clinical Oncology / Ausgabe 7/2020
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772 - DOI
- https://doi.org/10.1007/s10147-020-01654-5
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