Erschienen in:
01.06.2007 | Original Article
A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44
verfasst von:
Danièle Godelaine, Javier Carrasco, Francis Brasseur, Bart Neyns, Kris Thielemans, Thierry Boon, Aline Van Pel
Erschienen in:
Cancer Immunology, Immunotherapy
|
Ausgabe 6/2007
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Abstract
A panel of cytolytic T lymphocyte (CTL) clones was isolated from metastases and blood samples of a melanoma patient vaccinated with MAGE-3.A1-pulsed autologous dendritic cells. We report here the identification of a new antigen encoded by the MAGE-C2 cancer-germline gene. This antigen is recognized by some of these CTL on HLA-B*4403. The sequence of the peptide is SESIKKKVL. It is processed in various melanoma cell lines expressing MAGE-C2 and HLA-B*4403. Because of the expression pattern of gene MAGE-C2, this new antigen is strictly tumor-specific and could therefore be used for peptide-based antitumoral vaccination.