Skip to main content
main-content
Erschienen in: Brain Structure and Function 1/2018

31.08.2017 | Original Article

A nociceptive stress model of adolescent physical abuse induces contextual fear and cingulate nociceptive neuroplasticities

verfasst von: Brent A. Vogt, Leslie J. Vogt, Robert W. Sikes

Erschienen in: Brain Structure and Function | Ausgabe 1/2018

Einloggen, um Zugang zu erhalten

Abstract

Adolescent physical abuse impairs emotional development and evokes cingulate pathologies, but its neuronal and circuit substrates are unknown. Conditioning adolescent rabbits with noxious colorectal distension for only 2 h over 3 weeks simulated the human child abuse in amplitude, frequency, and duration. Thermal withdrawal thresholds were unchanged suggesting that sensitized spinal mechanisms may not be operable. Unchanged weight, stools, colorectal histology, and no evidence of abdominal pain argue against tissue injury or irritable bowel syndrome. Contextual fear was amplified as they avoided the site of their abuse. Conditioning impacted anterior cingulate and anterior midcingulate (ACC, aMCC) neuron excitability: (1) more neurons responded to cutaneous and visceral (VNox) noxious stimuli than controls engaging latent nociception (present but not manifest in controls). (2) Rear paw stimulation increased responses over forepaws with shorter onsets and longer durations, while forepaw responses were of higher amplitude. (3) There were more VNox responses with two excitatory phases and longer durations. (4) Some had unique three-phase excitatory responses. (5) Long-duration VNox stimuli did not inhibit neurons as in controls, suggesting the release of an inhibitory circuit. (6) aMCC changes in cutaneous but not visceral nociception confirmed its role in cutaneous nociception. For the first time, we report neuroplasticities that may be evoked by adolescent physical abuse and reflect psychogenic pain: i.e., no ongoing peripheral pain and altered ACC nociception. These limbic responses may be a cognitive trace of abuse and may shed light on impaired human emotional development and sexual function.
Literatur
Zurück zum Zitat Abeles M (1982) Quantification, smoothing, and confidence limits for single-units’ histograms. J Neurosci Meth 5:317–325 CrossRef Abeles M (1982) Quantification, smoothing, and confidence limits for single-units’ histograms. J Neurosci Meth 5:317–325 CrossRef
Zurück zum Zitat Abraham HD, Anderson C, Lee D (1997) Somatization disorder in sphincter of Oddi dysfunction. Psychosom Med 59(5):553–557 CrossRefPubMed Abraham HD, Anderson C, Lee D (1997) Somatization disorder in sphincter of Oddi dysfunction. Psychosom Med 59(5):553–557 CrossRefPubMed
Zurück zum Zitat Ackerman PT, Newton JEO, McPherson WB, Jones JG, Dykman RA (1998) Prevalence of posttraumatic stress disorder and other psychiatric diagnoses in three groups of abused children (sexual, physical, and both). Child Abuse Neg 22(8):759–774 CrossRef Ackerman PT, Newton JEO, McPherson WB, Jones JG, Dykman RA (1998) Prevalence of posttraumatic stress disorder and other psychiatric diagnoses in three groups of abused children (sexual, physical, and both). Child Abuse Neg 22(8):759–774 CrossRef
Zurück zum Zitat Al-Chaer ED, Kawasaki M, Pasricha PJ (2000) A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 119:1276–1285 CrossRefPubMed Al-Chaer ED, Kawasaki M, Pasricha PJ (2000) A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 119:1276–1285 CrossRefPubMed
Zurück zum Zitat Anglada-Figueroa D, Quirk GJ (2005) Lesions of the basal amygdala block expression of conditioned fear but not extinction. J Neurosci 25(42):9680–9685 CrossRefPubMed Anglada-Figueroa D, Quirk GJ (2005) Lesions of the basal amygdala block expression of conditioned fear but not extinction. J Neurosci 25(42):9680–9685 CrossRefPubMed
Zurück zum Zitat Bacon SJ, Headlam AJM, Gabbott PLA, Smith AD (1996) Amygdala input to medial prefrontal cortex (mPFC) in the rat: a light and electron microscope study. Brain Res 720:211–219 CrossRefPubMed Bacon SJ, Headlam AJM, Gabbott PLA, Smith AD (1996) Amygdala input to medial prefrontal cortex (mPFC) in the rat: a light and electron microscope study. Brain Res 720:211–219 CrossRefPubMed
Zurück zum Zitat Borja K, Ostrosy F (2013) Early traumatic events in psychopaths. J Forensic Sci 58(4):927–931 CrossRefPubMed Borja K, Ostrosy F (2013) Early traumatic events in psychopaths. J Forensic Sci 58(4):927–931 CrossRefPubMed
Zurück zum Zitat Bourdu S, Dapoigny M, Chapuy E, Artigue F, Vasson M-P, Dechelotte P, Bommelaer G, Eschalier A, Ardid D (2005) Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats. Gastroenterology 128:1996–2008 CrossRefPubMed Bourdu S, Dapoigny M, Chapuy E, Artigue F, Vasson M-P, Dechelotte P, Bommelaer G, Eschalier A, Ardid D (2005) Rectal instillation of butyrate provides a novel clinically relevant model of noninflammatory colonic hypersensitivity in rats. Gastroenterology 128:1996–2008 CrossRefPubMed
Zurück zum Zitat Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS (1999) Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156:1787–1795 PubMedPubMedCentral Bremner JD, Narayan M, Staib LH, Southwick SM, McGlashan T, Charney DS (1999) Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. Am J Psychiatry 156:1787–1795 PubMedPubMedCentral
Zurück zum Zitat Briere J, Elliot DM (2003) Prevalence and psychological sequelae of self-reported childhood physical and sexual abuse in a general population sample of men and women. Child Abuse Neg 27:1205–1222 CrossRef Briere J, Elliot DM (2003) Prevalence and psychological sequelae of self-reported childhood physical and sexual abuse in a general population sample of men and women. Child Abuse Neg 27:1205–1222 CrossRef
Zurück zum Zitat Brusberg M, Arvidsson S, Kang D, Larsson H, Lindstrom E, Martinez V (2009) CB receptors mediate the analgesic effects of cannabinoids 1 on colorectal distension-induced visceral pain in rodents. J Neurosci 29(5):1554–1564 CrossRefPubMed Brusberg M, Arvidsson S, Kang D, Larsson H, Lindstrom E, Martinez V (2009) CB receptors mediate the analgesic effects of cannabinoids 1 on colorectal distension-induced visceral pain in rodents. J Neurosci 29(5):1554–1564 CrossRefPubMed
Zurück zum Zitat Ciccone DS, Bandilla EB, W-h Wu (1997) Psychological dysfunction in patients with reflex sympathetic dystrophy. Pain 71:323–333 CrossRefPubMed Ciccone DS, Bandilla EB, W-h Wu (1997) Psychological dysfunction in patients with reflex sympathetic dystrophy. Pain 71:323–333 CrossRefPubMed
Zurück zum Zitat Dannlowski U, Stuhrmann A, Beutelmann V, Stuhrmann A, Redlich R, Grotegerd D, Dohm K, Sehlmeyer C, Konrad C, Baune BT, Arolt V, Heindel W, Zwitserlood P, Suslow T (2012) Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biolog Psychiatry 71:286–293 CrossRef Dannlowski U, Stuhrmann A, Beutelmann V, Stuhrmann A, Redlich R, Grotegerd D, Dohm K, Sehlmeyer C, Konrad C, Baune BT, Arolt V, Heindel W, Zwitserlood P, Suslow T (2012) Limbic scars: long-term consequences of childhood maltreatment revealed by functional and structural magnetic resonance imaging. Biolog Psychiatry 71:286–293 CrossRef
Zurück zum Zitat Dannlowski U, Kugel H, Huber F, Stuhrmann A, Redlich R, Grotegerd D, Dohm K, Sehlmeyer C, Konrad C, Baune BT, Arolt V, Heindel W, Zwitserlood P, Suslow T (2013) Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala. Hum Brain Map 34:2899–2909 CrossRef Dannlowski U, Kugel H, Huber F, Stuhrmann A, Redlich R, Grotegerd D, Dohm K, Sehlmeyer C, Konrad C, Baune BT, Arolt V, Heindel W, Zwitserlood P, Suslow T (2013) Childhood maltreatment is associated with an automatic negative emotion processing bias in the amygdala. Hum Brain Map 34:2899–2909 CrossRef
Zurück zum Zitat Davey NJ, Ellaway PH, Stein RB (1986) Statistical limits for detecting change in the cumulative sum derivative of the peristimulus time histogram. J Neurosci Meth 17:153–166 CrossRef Davey NJ, Ellaway PH, Stein RB (1986) Statistical limits for detecting change in the cumulative sum derivative of the peristimulus time histogram. J Neurosci Meth 17:153–166 CrossRef
Zurück zum Zitat Davila GW, Bernier F, Franco J, Kopka SI (2003) Bladder dysfunction in sexual abuse survivors. J Urol 170:476–479 CrossRefPubMed Davila GW, Bernier F, Franco J, Kopka SI (2003) Bladder dysfunction in sexual abuse survivors. J Urol 170:476–479 CrossRefPubMed
Zurück zum Zitat Davis DA, Luecken LJ, Zautra AJ (2005) Are reports of childhood abuse related to the experience of chronic pain in adulthood? A meta-analytic review of the literature. Clin J Pain 21(5):398–405 CrossRefPubMed Davis DA, Luecken LJ, Zautra AJ (2005) Are reports of childhood abuse related to the experience of chronic pain in adulthood? A meta-analytic review of the literature. Clin J Pain 21(5):398–405 CrossRefPubMed
Zurück zum Zitat Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149–158 CrossRefPubMed Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149–158 CrossRefPubMed
Zurück zum Zitat Driscoll CA, Barr CS (2016) Studying longitudinal trajectories in animal models of psychiatric illness and their translation to the human condition. Neurosci Res 102:67–77 CrossRefPubMed Driscoll CA, Barr CS (2016) Studying longitudinal trajectories in animal models of psychiatric illness and their translation to the human condition. Neurosci Res 102:67–77 CrossRefPubMed
Zurück zum Zitat Drossman DA, Ringel Y, Vogt BA, Leserman J, Lin W, Smith JK, Whitehead W (2003) Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome. Gastroenterology 124(3):754–761 PubMed PMID: 12612913 CrossRefPubMed Drossman DA, Ringel Y, Vogt BA, Leserman J, Lin W, Smith JK, Whitehead W (2003) Alterations of brain activity associated with resolution of emotional distress and pain in a case of severe irritable bowel syndrome. Gastroenterology 124(3):754–761 PubMed PMID: 12612913 CrossRefPubMed
Zurück zum Zitat Drummond E, Wisniewski T (2017) Alzheimer’s disease: experimental models and reality. Acta Neuropathol 133:155–175 CrossRefPubMed Drummond E, Wisniewski T (2017) Alzheimer’s disease: experimental models and reality. Acta Neuropathol 133:155–175 CrossRefPubMed
Zurück zum Zitat Ellaway PH (1978) Cumulative sum technique and its application to the analysis of peristimulus time histograms. Electroencephalogr Clin Neurophysiol 45:302–304 CrossRefPubMed Ellaway PH (1978) Cumulative sum technique and its application to the analysis of peristimulus time histograms. Electroencephalogr Clin Neurophysiol 45:302–304 CrossRefPubMed
Zurück zum Zitat Fergusson DM, Boden JM, Horwood LJ (2008) Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Ab Neg 32:607–619 CrossRef Fergusson DM, Boden JM, Horwood LJ (2008) Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Ab Neg 32:607–619 CrossRef
Zurück zum Zitat Finkelhor D, Turner H, Ormrod R, Hamby SL (2009) Violence, abuse, and crime exposure in a national sample of children and youth. Pediatrics 124:1411–1423 CrossRefPubMed Finkelhor D, Turner H, Ormrod R, Hamby SL (2009) Violence, abuse, and crime exposure in a national sample of children and youth. Pediatrics 124:1411–1423 CrossRefPubMed
Zurück zum Zitat Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ (2004) The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 304:881–883 CrossRefPubMed Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ (2004) The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 304:881–883 CrossRefPubMed
Zurück zum Zitat Gabbott PLA, Warner TA, Busby SJ (2006) Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex. Neuroscience 139:1039–1048 CrossRefPubMed Gabbott PLA, Warner TA, Busby SJ (2006) Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex. Neuroscience 139:1039–1048 CrossRefPubMed
Zurück zum Zitat Gabriel M, Kubota Y, Sparenborg S, Straube K, Vogt BA (1991) Effects of cingulate cortical lesions on avoidance learning and training-induced unit activity in rabbits. Exp Brain Res 86(3):585–600 (PubMed PMID: 1761092) CrossRefPubMed Gabriel M, Kubota Y, Sparenborg S, Straube K, Vogt BA (1991) Effects of cingulate cortical lesions on avoidance learning and training-induced unit activity in rabbits. Exp Brain Res 86(3):585–600 (PubMed PMID: 1761092) CrossRefPubMed
Zurück zum Zitat Gao J, Wu X, Owyang C, Li Y (2006) Enhanced responses of the anterior cingulate cortex neurones to colonic distension in viscerally hypersensitive rats. J Physiol 70(1):169–183 CrossRef Gao J, Wu X, Owyang C, Li Y (2006) Enhanced responses of the anterior cingulate cortex neurones to colonic distension in viscerally hypersensitive rats. J Physiol 70(1):169–183 CrossRef
Zurück zum Zitat Goshen I, Brodsky M, Prakash R, Wallace D, Gradinaru V, Ramakrishnan C, Deisseroth K (2011) Dynamics of retrieval strategies for remote memories. Cell 147:678–689 CrossRefPubMed Goshen I, Brodsky M, Prakash R, Wallace D, Gradinaru V, Ramakrishnan C, Deisseroth K (2011) Dynamics of retrieval strategies for remote memories. Cell 147:678–689 CrossRefPubMed
Zurück zum Zitat Grilo CM, Sanislow C, Fehon DC, Martino S, McGlashan TH (1999) Psychological and Behavioral functioning in adolescent psychiatric inpatients who report histories of childhood abuse. Am J Psychiatry 156:538–543 PubMed Grilo CM, Sanislow C, Fehon DC, Martino S, McGlashan TH (1999) Psychological and Behavioral functioning in adolescent psychiatric inpatients who report histories of childhood abuse. Am J Psychiatry 156:538–543 PubMed
Zurück zum Zitat Grow DA, McCarrey JR, Navara CS (2016) Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson’s disease. Stem Cell Res 17:352–366 CrossRefPubMed Grow DA, McCarrey JR, Navara CS (2016) Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson’s disease. Stem Cell Res 17:352–366 CrossRefPubMed
Zurück zum Zitat Harlow BL, Stewart EG (2005) Adult-onset vulvodynia in relation to childhood violence victimization. Am J Epidemiol 161(9):871–880 CrossRefPubMed Harlow BL, Stewart EG (2005) Adult-onset vulvodynia in relation to childhood violence victimization. Am J Epidemiol 161(9):871–880 CrossRefPubMed
Zurück zum Zitat Hassett AL, Hilliard PE, Goesling J, Clauw DJ, Harte SE, Brummett CM (2013) Reports of chronic pain in childhood and adolescence among patients at a tertiary care pain clinic. J Pain 14(11):1390–1397 CrossRefPubMed Hassett AL, Hilliard PE, Goesling J, Clauw DJ, Harte SE, Brummett CM (2013) Reports of chronic pain in childhood and adolescence among patients at a tertiary care pain clinic. J Pain 14(11):1390–1397 CrossRefPubMed
Zurück zum Zitat Hill R (2000) NK (substance P) receptor antagonists—why are they not analgesic in humans? Trd Pharmacol Sci 21:244–246 CrossRef Hill R (2000) NK (substance P) receptor antagonists—why are they not analgesic in humans? Trd Pharmacol Sci 21:244–246 CrossRef
Zurück zum Zitat Imbierowicz K, Egle UT (2003) Childhood adversities in patients with fibromyalgia and somatoform pain disorder. Eur J Pain 7:113–119 CrossRefPubMed Imbierowicz K, Egle UT (2003) Childhood adversities in patients with fibromyalgia and somatoform pain disorder. Eur J Pain 7:113–119 CrossRefPubMed
Zurück zum Zitat Ji G, Sun H, Fu Y, Li Z, Pais-Vieira M, Galhardo V, Neugebauer V (2010) Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. J Neurosci 30(15):5451–5464 CrossRefPubMedPubMedCentral Ji G, Sun H, Fu Y, Li Z, Pais-Vieira M, Galhardo V, Neugebauer V (2010) Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. J Neurosci 30(15):5451–5464 CrossRefPubMedPubMedCentral
Zurück zum Zitat Johansen JP, Fields HL, Manning BH (2001) The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex. Proc Natl Acad Sci USA 98(14):8077–8082 CrossRefPubMedPubMedCentral Johansen JP, Fields HL, Manning BH (2001) The affective component of pain in rodents: direct evidence for a contribution of the anterior cingulate cortex. Proc Natl Acad Sci USA 98(14):8077–8082 CrossRefPubMedPubMedCentral
Zurück zum Zitat Kalisch R, Mueller MB, Tuesche O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 38:e92 CrossRefPubMed Kalisch R, Mueller MB, Tuesche O (2015) A conceptual framework for the neurobiological study of resilience. Behav Brain Sci 38:e92 CrossRefPubMed
Zurück zum Zitat Kang H, Dalager N, Mahan C, Ishii E (2005) The role of sexual assault on the risk of PTSD among Gulf War veterans. Ann Epidemiol 15:191–195 CrossRefPubMed Kang H, Dalager N, Mahan C, Ishii E (2005) The role of sexual assault on the risk of PTSD among Gulf War veterans. Ann Epidemiol 15:191–195 CrossRefPubMed
Zurück zum Zitat Kap YS, Jagessar SA, Dunham J, Hart BA (2016) The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis. Drug Discov Today 21(8):1200–1205 CrossRefPubMed Kap YS, Jagessar SA, Dunham J, Hart BA (2016) The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis. Drug Discov Today 21(8):1200–1205 CrossRefPubMed
Zurück zum Zitat Keiley MK, Howe TR, Dodge KA, Bates DEJE, Pettit GS (2001) The timing of child physical maltreatment: a cross-domain growth analysis of impact on adolescent externalizing and internalizing problems. Devel Psychopath 13:891–912 Keiley MK, Howe TR, Dodge KA, Bates DEJE, Pettit GS (2001) The timing of child physical maltreatment: a cross-domain growth analysis of impact on adolescent externalizing and internalizing problems. Devel Psychopath 13:891–912
Zurück zum Zitat Kenshalo DR Jr, Iwata K, Sholas M, Thomas DA (2000) Response properties and organization of nociceptive neurons in area 1 of monkey primary somatosensory cortex. J Neurophysiol 84:719–729 CrossRefPubMed Kenshalo DR Jr, Iwata K, Sholas M, Thomas DA (2000) Response properties and organization of nociceptive neurons in area 1 of monkey primary somatosensory cortex. J Neurophysiol 84:719–729 CrossRefPubMed
Zurück zum Zitat Kleim B, Galatzer-Levy IR (2015) Appreciating methodological complexity and integrating neurobiological perspectives to advance the science of resilience. Behav Brain Sci. 38:e108 CrossRefPubMed Kleim B, Galatzer-Levy IR (2015) Appreciating methodological complexity and integrating neurobiological perspectives to advance the science of resilience. Behav Brain Sci. 38:e108 CrossRefPubMed
Zurück zum Zitat Kuo C-C, Yen C-T (2005) Comparison of anterior cingulate and primary somatosensory neuronal responses to noxious laser-heat stimuli in conscious, behaving rats. J Neurophysiol 94:1825–1836. doi: 10.​1152/​jn.​00294 CrossRefPubMed Kuo C-C, Yen C-T (2005) Comparison of anterior cingulate and primary somatosensory neuronal responses to noxious laser-heat stimuli in conscious, behaving rats. J Neurophysiol 94:1825–1836. doi: 10.​1152/​jn.​00294 CrossRefPubMed
Zurück zum Zitat Leonard LM, Follette VM (2002) Sexual functioning in women reporting a history of child sexual abuse: review of the empirical literature and clinical implications. Ann Rev Sex Res 13:346–388 Leonard LM, Follette VM (2002) Sexual functioning in women reporting a history of child sexual abuse: review of the empirical literature and clinical implications. Ann Rev Sex Res 13:346–388
Zurück zum Zitat Leserman J, Drossman DA, Li Z, Toomey TC, Nachman G, Glogau L (1996) Sexual and physical abuse history in gastroenterology practice: how types of abuse impact health status. Psychosom Med 58:4–15 CrossRefPubMed Leserman J, Drossman DA, Li Z, Toomey TC, Nachman G, Glogau L (1996) Sexual and physical abuse history in gastroenterology practice: how types of abuse impact health status. Psychosom Med 58:4–15 CrossRefPubMed
Zurück zum Zitat Leserman J, Li Z, Drossman DA, Toomey TC, Nachman G, Glogau L (1997) Impact of sexual and physical abuse dimensions on health status: development of an abuse severity measure. Psychosom Med 59:152–160 CrossRefPubMed Leserman J, Li Z, Drossman DA, Toomey TC, Nachman G, Glogau L (1997) Impact of sexual and physical abuse dimensions on health status: development of an abuse severity measure. Psychosom Med 59:152–160 CrossRefPubMed
Zurück zum Zitat Lieb K, Zanarini MC, Schmahl C, Linehan MM, Bohus M (2004) Borderline personality disorder. Lancet 364:453–461 CrossRefPubMed Lieb K, Zanarini MC, Schmahl C, Linehan MM, Bohus M (2004) Borderline personality disorder. Lancet 364:453–461 CrossRefPubMed
Zurück zum Zitat Maren S, Phan KL, Liberzon I (2013) The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 14:417–428 CrossRefPubMedPubMedCentral Maren S, Phan KL, Liberzon I (2013) The contextual brain: implications for fear conditioning, extinction and psychopathology. Nat Rev Neurosci 14:417–428 CrossRefPubMedPubMedCentral
Zurück zum Zitat McBeth J, Macfarlane GJ, Benjamine S, Morris S, Silman AJ (1999) The association between tender points, psychological distress and adverse childhood experiences. Arth Rheum 42:1397–1404 CrossRef McBeth J, Macfarlane GJ, Benjamine S, Morris S, Silman AJ (1999) The association between tender points, psychological distress and adverse childhood experiences. Arth Rheum 42:1397–1404 CrossRef
Zurück zum Zitat Messaoudi MI, Desor D, Grasmuëck V, Joyeux M, Langlois A, Roman FJ (1999) Behavioral evaluation of visceral pain in a rat model of colonic inflammation. NeuroReport 10:1137–1141 CrossRefPubMed Messaoudi MI, Desor D, Grasmuëck V, Joyeux M, Langlois A, Roman FJ (1999) Behavioral evaluation of visceral pain in a rat model of colonic inflammation. NeuroReport 10:1137–1141 CrossRefPubMed
Zurück zum Zitat Mogil JS, Davis KD, Derbyshire SW (2010) The necessity of animal models in pain research. Pain 151:12–17 CrossRefPubMed Mogil JS, Davis KD, Derbyshire SW (2010) The necessity of animal models in pain research. Pain 151:12–17 CrossRefPubMed
Zurück zum Zitat Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y (2014) Investigation of chronic musculoskeletal pain (third report): with special reference to the importance of neuropathic pain and psychogenic pain. J Orthop Sci 19:667–675. doi: 10.​1007/​s00776-014-0567-6 CrossRefPubMedPubMedCentral Nakamura M, Nishiwaki Y, Sumitani M, Ushida T, Yamashita T, Konno S, Taguchi T, Toyama Y (2014) Investigation of chronic musculoskeletal pain (third report): with special reference to the importance of neuropathic pain and psychogenic pain. J Orthop Sci 19:667–675. doi: 10.​1007/​s00776-014-0567-6 CrossRefPubMedPubMedCentral
Zurück zum Zitat Oliver E, Baker SN, Nakajima K, Brochier T, Lemon RN (2001) Investigation into non-monosynaptic corticospinal excitation of macaque upper limb single motor units. J Neurophysiol 86:1573–1586 CrossRef Oliver E, Baker SN, Nakajima K, Brochier T, Lemon RN (2001) Investigation into non-monosynaptic corticospinal excitation of macaque upper limb single motor units. J Neurophysiol 86:1573–1586 CrossRef
Zurück zum Zitat Pastoriza LN, Morrow TJ, Casey KL (1996) Medial frontal cortex lesions selectively attenuate the hot plate response: possible nocifensive apraxia in the rat. Pain 64:11–17 CrossRefPubMed Pastoriza LN, Morrow TJ, Casey KL (1996) Medial frontal cortex lesions selectively attenuate the hot plate response: possible nocifensive apraxia in the rat. Pain 64:11–17 CrossRefPubMed
Zurück zum Zitat Pietrek C, Elbert T, Weierstall R, Müller O, Rockstroh B (2013) Childhood adversities in relation to psychiatric disorders. Psychiatry Res 206:103–110 CrossRefPubMed Pietrek C, Elbert T, Weierstall R, Müller O, Rockstroh B (2013) Childhood adversities in relation to psychiatric disorders. Psychiatry Res 206:103–110 CrossRefPubMed
Zurück zum Zitat Ren L-Y, Lu Z-M, Liu M-G, Yu Y-Q, Li Z, Shang GW, Chen J (2008) Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom–induced pain behaviors. Neuroscience 153:268–278 CrossRefPubMed Ren L-Y, Lu Z-M, Liu M-G, Yu Y-Q, Li Z, Shang GW, Chen J (2008) Distinct roles of the anterior cingulate cortex in spinal and supraspinal bee venom–induced pain behaviors. Neuroscience 153:268–278 CrossRefPubMed
Zurück zum Zitat Rickman DW (1999) Parvalbumin immunoreactivity is enhanced by brain-derived neurotrophic factor in organotypic cultures of rat retina. J Neurobiol 41:376–384 CrossRefPubMed Rickman DW (1999) Parvalbumin immunoreactivity is enhanced by brain-derived neurotrophic factor in organotypic cultures of rat retina. J Neurobiol 41:376–384 CrossRefPubMed
Zurück zum Zitat Riley JL III, Robinson ME, Kvaal SA, Gremillion HA (1998) Effects of physical and sexual abuse in facial pain: direct or mediated? Cranio 16(4):259–266 CrossRefPubMed Riley JL III, Robinson ME, Kvaal SA, Gremillion HA (1998) Effects of physical and sexual abuse in facial pain: direct or mediated? Cranio 16(4):259–266 CrossRefPubMed
Zurück zum Zitat Ringel Y, Drossman DA, Leserman JL, Suyenobu BY, Wilber K, Lin W, Whitehead WE, Naliboff BD, Berman S, Mayer EA (2008) Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an fMRI study. Gastroenterology 134:396–404 CrossRefPubMed Ringel Y, Drossman DA, Leserman JL, Suyenobu BY, Wilber K, Lin W, Whitehead WE, Naliboff BD, Berman S, Mayer EA (2008) Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an fMRI study. Gastroenterology 134:396–404 CrossRefPubMed
Zurück zum Zitat Sakata K, Woo NH, Martinowich K, Greene JS, Schloesser RJ, Shen L, Lu B (2009) Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc Natl Acad Sci 106(14):5942–5947 CrossRefPubMedPubMedCentral Sakata K, Woo NH, Martinowich K, Greene JS, Schloesser RJ, Shen L, Lu B (2009) Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc Natl Acad Sci 106(14):5942–5947 CrossRefPubMedPubMedCentral
Zurück zum Zitat Scutter SD, Türker KS (1999) Muscle spindle afferent input to motoneurons in human masseter. J Neurophysiol 82:505–507 CrossRefPubMed Scutter SD, Türker KS (1999) Muscle spindle afferent input to motoneurons in human masseter. J Neurophysiol 82:505–507 CrossRefPubMed
Zurück zum Zitat Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD (2007) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27(9):2349–2356 CrossRefPubMedPubMedCentral Seeley WW, Menon V, Schatzberg AF, Keller J, Glover GH, Kenna H, Reiss AL, Greicius MD (2007) Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci 27(9):2349–2356 CrossRefPubMedPubMedCentral
Zurück zum Zitat Sikes RW, Vogt LJ, Vogt BA (2008) Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex. Pain 135(1–2):160–174 CrossRefPubMed Sikes RW, Vogt LJ, Vogt BA (2008) Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex. Pain 135(1–2):160–174 CrossRefPubMed
Zurück zum Zitat Smith HC, Davey NJ, Savic GD, Maskill W, Ellaway PH, Jamous MA, Frankel HL (2000) Modulation of single motor unit discharges using magnetic stimulation of the motor cortex in incomplete spinal cord injury. J Neurol Neurosurg Psychiatry 68:516–520 CrossRefPubMedPubMedCentral Smith HC, Davey NJ, Savic GD, Maskill W, Ellaway PH, Jamous MA, Frankel HL (2000) Modulation of single motor unit discharges using magnetic stimulation of the motor cortex in incomplete spinal cord injury. J Neurol Neurosurg Psychiatry 68:516–520 CrossRefPubMedPubMedCentral
Zurück zum Zitat Street AE, Stafford J, Mahan CM, Hendricks A (2008) Sexual harassment and assault experienced by reservists during military service: prevalence and health correlates. J Rehab Res Dev 45:409–420 CrossRef Street AE, Stafford J, Mahan CM, Hendricks A (2008) Sexual harassment and assault experienced by reservists during military service: prevalence and health correlates. J Rehab Res Dev 45:409–420 CrossRef
Zurück zum Zitat Tesarz J, Eich W, Treede R-D, Gerhardt A (2016) Altered pressure pain thresholds and increased wind-up in adult chronic back pain patients with a history of childhood maltreatment: a quantitative sensory testing study. Pain published online Tesarz J, Eich W, Treede R-D, Gerhardt A (2016) Altered pressure pain thresholds and increased wind-up in adult chronic back pain patients with a history of childhood maltreatment: a quantitative sensory testing study. Pain published online
Zurück zum Zitat Vaccarino AL, Melzack R (1989) Analgesia produced by injection of lidocaine into the anterior cingulum bundle of the rat. Pain 39:213–219 CrossRefPubMed Vaccarino AL, Melzack R (1989) Analgesia produced by injection of lidocaine into the anterior cingulum bundle of the rat. Pain 39:213–219 CrossRefPubMed
Zurück zum Zitat Vaculin S, Franek M, Vejrazk M (2010) Role of oxidative stress in animal model of visceral pain. Neurosci Lett 477:82–85 CrossRefPubMed Vaculin S, Franek M, Vejrazk M (2010) Role of oxidative stress in animal model of visceral pain. Neurosci Lett 477:82–85 CrossRefPubMed
Zurück zum Zitat van Harmelen A-L, van Tol M-J, van der Wee NJA, Veltman DJ, Aleman A, Spinhoven P, van Buchem MA, Zitman FG, Penninx BWJH, Elzinga BM (2010) Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biol Psychiatry 68:832–838 CrossRefPubMed van Harmelen A-L, van Tol M-J, van der Wee NJA, Veltman DJ, Aleman A, Spinhoven P, van Buchem MA, Zitman FG, Penninx BWJH, Elzinga BM (2010) Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biol Psychiatry 68:832–838 CrossRefPubMed
Zurück zum Zitat Vogt BA (2005) Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6(7):533–544 (Pain and emotion interactions in subregions of the cingulate gyrus) CrossRefPubMedPubMedCentral Vogt BA (2005) Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev Neurosci 6(7):533–544 (Pain and emotion interactions in subregions of the cingulate gyrus) CrossRefPubMedPubMedCentral
Zurück zum Zitat Vogt BA, Peters A (1981) Form and distribution of neurons in rat cingulate cortex: areas 32, 24, and 29. J Comp Neurol. 195(4):603–625 PubMed PMID:7462444 CrossRefPubMed Vogt BA, Peters A (1981) Form and distribution of neurons in rat cingulate cortex: areas 32, 24, and 29. J Comp Neurol. 195(4):603–625 PubMed PMID:7462444 CrossRefPubMed
Zurück zum Zitat Vogt DS, Pless AP, King LA, King DW (2005) Deployment stressors, gender, and mental health outcomes among Gulf War I veterans. J Traum Stress 18:115–127 CrossRef Vogt DS, Pless AP, King LA, King DW (2005) Deployment stressors, gender, and mental health outcomes among Gulf War I veterans. J Traum Stress 18:115–127 CrossRef
Zurück zum Zitat Wang Z, Bradesi S, Charles JR, Pang RD, Maarek J-MI, Mayer RA, Holschneider DP (2000) Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain 152:2746–2756 CrossRef Wang Z, Bradesi S, Charles JR, Pang RD, Maarek J-MI, Mayer RA, Holschneider DP (2000) Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain 152:2746–2756 CrossRef
Zurück zum Zitat Yan N, Cao B, Xu J, Hao C, Zhang X, Li Y (2012) Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats. Neurobiol Learn Mem 97:156–164 CrossRefPubMed Yan N, Cao B, Xu J, Hao C, Zhang X, Li Y (2012) Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats. Neurobiol Learn Mem 97:156–164 CrossRefPubMed
Zurück zum Zitat Yehuda R, Antelman SM (1993) Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol Psychiatry 33:479–486 CrossRefPubMed Yehuda R, Antelman SM (1993) Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol Psychiatry 33:479–486 CrossRefPubMed
Zurück zum Zitat Zhang H-Q, Rong P-J, Zhang S-P, Al-Chaer ED, Willis WD (2003) Noxious visceral inputs enhance cutaneous tactile response in rat thalamus. Neurosci Lett 336:109–112 CrossRefPubMed Zhang H-Q, Rong P-J, Zhang S-P, Al-Chaer ED, Willis WD (2003) Noxious visceral inputs enhance cutaneous tactile response in rat thalamus. Neurosci Lett 336:109–112 CrossRefPubMed
Metadaten
Titel
A nociceptive stress model of adolescent physical abuse induces contextual fear and cingulate nociceptive neuroplasticities
verfasst von
Brent A. Vogt
Leslie J. Vogt
Robert W. Sikes
Publikationsdatum
31.08.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Brain Structure and Function / Ausgabe 1/2018
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-017-1502-3