nach oben

Clinical Rheumatology

Erschienen in:

16.03.2018 | Original Article

A novel biomarker in patients with knee osteoarthritis: adropin

verfasst von: Gulsah Gundogdu, Koksal Gundogdu

Erschienen in: Clinical Rheumatology | Ausgabe 8/2018

Einloggen, um Zugang zu erhalten

Abstract

Adropin is newly discovered peptide hormone. Osteoarthritis (OA) is a kind of joint disease characterized by progressive joint cartilage loss and joint pain. The present study was carried out to investigate adropin and tumor necrosis factor alpha (TNF-α) levels and the relationship between adropin in patients with knee OA classified by Kellgren-Lawrence (KL). A total of 60 knee OA patients and 30 healthy controls were included in this study. KL grading was carried out using the radiographic findings. Demographic characteristics and laboratory parameters were recorded. Adropin and TNF-α levels were determined by using enzyme-linked immunosorbent assay (ELISA). Adropin level was lower in the knee OA patients compared with the healthy controls (p < 0.001), whereas TNF-α level was higher (p < 0.001). Adropin level was negatively correlated with TNF-α level, blood white blood cell (WBC) count, and neutrophil-lymphocyte ratio (NLR). However, there was a significant decrease in adropin level and an increase in TNF-α level parallel to the increase in the KL grade. In addition, serum adropin level was found to be significantly lower in KL grade 1 groups compared with healthy controls (p < 0.01). There was a decrease in adropin level parallel to the increase in the body mass index (BMI), and there was a statistically significant decrease in adropin level in knee OA patients higher than BMI > 30 (p < 0.01). Mean NLR of KL grade 4 was significantly increased compared with other grades (p < 0.05). The consequence of the present study suggested that serum adropin level could be used as a new biomarker indicating the early grade of knee OA.

Nawaz MS, Amer N, Asim HM (2017) Grade 1-2 osteoarthritis of knee joint; outcome of combination of grade 1-2 knee joint mobilization with quadriceps isometrics in patients. Professional Med J 24(7):986–991CrossRef

Hurwitz EL, Carragee EJ, van der Velde G, Carroll LJ, Nordin M, Guzman J, Peloso PM, Holm LW, Cote P, Hogg-Johnson S, Cassidy JD, Haldeman S (2009) Treatment of neck pain: noninvasive interventions: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. J Manipulative Physiol Ther 32(2 Suppl):141–175

Uysal FG, Basaran S (2009) Knee Osteoarthritis. Turk Fiz Tip Rehab D 55:1–7

Sokolove J, Lepus CM (2013) Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis 5(2):77–94CrossRefPubMedPubMedCentral

Maldonado M, Nam J (2013) The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. Biomed Res Int 2013:284873CrossRefPubMedPubMedCentral

Amin S, LaValley MP, Guermazi A, Grigoryan M, Hunter DJ, Clancy M, Niu JB, Gale DR, Felson DT (2005) The relationship between cartilage loss on magnetic resonance imaging and radiographic progression in men and women with knee osteoarthritis. Arthritis Rheum 52(10):3152–3159CrossRefPubMed

Kellgren JH, Lawrence JS (1957) Radiological assessment of osteoarthritis. Ann Rheum Dis 16(4):494–502CrossRefPubMedPubMedCentral

Katz JD, Agrawal S, Velasquez M (2010) Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome. Curr Opin Rheumatol 22(5):512–519CrossRefPubMed

Bondeson J, Blom AB, Wainwright S, Hughes C, Caterson B, van den Berg WB (2010) The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis. Arthritis Rheum 62(3):647–657CrossRefPubMed

10.

Franke S, Sommer M, Ruster C, Bondeva T, Marticke J, Hofmann G, Hein G, Wolf G (2009) Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells. Arthritis Res Ther 11(5):1–19CrossRef

11.

Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW, Mynatt RL, Burris TP, Dong JZ, Halem HA, Culler MD, Heisler LK, Stephens JM, Butler AA (2008) Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism. Cell Metab 8(6):468-481CrossRefPubMedPubMedCentral

12.

Lian WL, Gu XS, Qin YW, Zheng X (2011) Elevated Plasma Levels of Adropin in Heart Failure Patients. Internal Med 50(15):1523–1527CrossRef

13.

Butler AA, Tam CS, Stanhope KL, Wolfe BM, Ali MR, O’Keeffe M, St-Onge MP, Ravussin E, Havel PJ (2012) Low Circulating Adropin Concentrations with Obesity and Aging Correlate with Risk Factors for Metabolic Disease and Increase after Gastric Bypass Surgery in Humans. J Clin Endocr Metab 97(10):3783–3791CrossRefPubMed

14.

Chen M, Ouyang F, Zhou SH (2015) Adropin as a novel energy factor likely has the ability to regulate blood pressure. Med Hypotheses 85(2):234CrossRefPubMed

15.

Celik E, Yilmaz E, Celik O, Ulas M, Turkcuoglu I, Karaer A, Simsek Y, Minareci Y, Aydin S (2013) Maternal and fetal adropin levels in gestational diabetes mellitus. J Perinat Med 41(4):375–380CrossRefPubMed

16.

Gu XS, Li H, Zhu XY, Gu HB, Chen JC, Wang LC, Harding P, Xu WT (2015) Inverse correlation between plasma adropin and ET-1 levels in essential hypertension: a cross-sectional study. Medicine 94(40):1–5CrossRef

17.

Kumar KG, Zhang JY, Gao S, Rossi J, McGuinness OP, Halem HH, Culler MD, Mynatt RL, Butler AA (2012) Adropin Deficiency Is Associated With Increased Adiposity and Insulin Resistance. Obesity 20(7):1394–1402

18.

Li ZM, Li M (2017) Improvement in orthopedic outcome score and reduction in IL-1β, CXCL13, and TNF-α in synovial fluid of osteoarthritis patients following arthroscopic knee surgery. Genet Mol Res 16(3):1–9CrossRef

19.

Sasek C (2015) An update on primary care management of knee osteoarthritis. Jaapa-J Am Acad Phys 28(1):37-44

20.

Johnson VL, Hunter DJ (2014) The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol 28:5–15CrossRefPubMed

21.

Grazio S, Balen D (2009) Obesity: risk factor and predictor of osteoarthritis. Lijec Vjesn 131(1–2):22–26PubMed

22.

Lementowski PW, Zelicof SB (2008) Obesity and osteoarthritis. Am J Orthop 37:148–151PubMed

23.

Engstrom G, de Verdier MG, Rollof J, Nilsson PM, Lohmander LS (2009) C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study. Osteoarthr Cartilage 17(2):168–173

24.

Gandhi R, Razak F, Tso P, Davey JR, Mahomed NN (2010) Asian ethnicity and the prevalence of metabolic syndrome in the osteoarthritic total knee arthroplasty population. J Arthroplast 25(3):416–419CrossRef

25.

Han CD, Yang IH, Lee WS, Park YJ, Park KK (2013) Correlation between metabolic syndrome and knee osteoarthritis: data from the Korean National Health and Nutrition Examination Survey (KNHANES). BMC Public Health 13(603):1–8

26.

Hussain SM, Wang YY, Cicuttini FM, Simpson JA, Giles GG, Graves S, Wluka AE (2014) Incidence of total knee and hip replacement for osteoarthritis in relation to the metabolic syndrome and its components: A prospective cohort study. Semin Arthritis Rheu 43(4):429–436CrossRef

27.

Kurz B, Lemke AK, Fay J, Pufe T, Grodzinsky AJ, Schünke M (2005) Pathomechanisms of cartilage destruction by mechanical injury. Ann Anat 187:473–485CrossRefPubMed

28.

Vasilic-Brasnjevic S, Marinkovic J, Vlajinac H, Vasiljevic N, Jakovljevic B, Nikic M, Maksimovic M (2016) Association of body mass index and waist circumference with severity of knee osteoarthritis. Acta Reumatol Port 41:226–231PubMed

29.

Sayin O, Tokgoz Y, Arslan N (2014) Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease. J Pediatr Endocr Met 27(5-6):479–484

30.

Topuz M, Celik A, Aslantas T, Demir AK, Aydin S, Aydin S (2013) Plasma Adropin Levels Predict Endothelial Dysfunction Like Flow-Mediated Dilatation in Patients With Type 2 Diabetes Mellitus. J Invest Med 61(8):1161–1164CrossRef

31.

Orlowsky EW, Kraus VB (2015) The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive. J Rheumatol 42(3):363–371CrossRefPubMedPubMedCentral

32.

He R, Yang L, Guo L (2011) Painful locking of the knee due to bucket handle tear of mediopatellar plica. Chin J Traumatol 14:117–119PubMed

33.

Nelson FR (2014) A background for the management of osteoarthritic knee pain. Pain Manag 4(6):427–436CrossRefPubMed

34.

Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose Expression of Tumor-Necrosis-Factor-Alpha - Direct Role in Obesity-Linked Insulin Resistance. Science 259(5091):87–91CrossRefPubMed

35.

Spiegelman BM, Flier JS (2001) Obesity and the regulation of energy balance. Cell 104(4):531–543CrossRefPubMed

36.

Chen XP, Xun KL, Chen LD, Wang YT (2009) TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct 27(7):407–416CrossRefPubMed

37.

Gupta-Ganguli M, Cox K, Means B, Gerling I, Solomon SS (2011) Does therapy with anti-TNF-alpha improve glucose tolerance and control in patients with type 2 diabetes? Diabetes Care 34(7):e121CrossRefPubMedPubMedCentral

38.

Finck BN, Johnson RW (2000) Tumor necrosis factor-alpha regulates secretion of the adipocyte-derived cytokine, leptin. Microsc Res Techniq 50(3):209–215CrossRef

39.

Rask-Madsen C, Dominguez H, Ihlemann N, Hermann T, Kober L, Torp-Pedersen C (2003) Tumor necrosis factor-alpha inhibits insulin’s stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 108(15):1815–1821CrossRefPubMed

40.

Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK (2005) Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54:2939–2945CrossRefPubMed

41.

Shao N, Cai Q (2015) High pretreatment neutrophil-lymphocyte ratio predicts recurrence and poor prognosis for combined small cell lung cancer. Clin Transl Oncol 17(10):772–778CrossRefPubMed

42.

Buyukkaya E, Karakas MF, Karakas E, Akcay AB, Tanboga IH, Kurt M, Sen N (2014) Correlation of neutrophil to lymphocyte ratio with the presence and severity of metabolic syndrome. Clin Appl Thromb Hemost 20(2):159–163CrossRefPubMed

43.

Demirci S, Demirci S, Kutluhan S, Koyuncuoğlu HR, Yürekli VA (2016) The clinical significance of the neutrophil-to-lymphocyte ratio in multiple sclerosis. Int J Neurosci 126(8):700–706PubMed

44.

Suliman MARM, Juma AAB, Almadhani AAA, Pathare AV, Alkindi SSA, Werner FU (2010) Predictive Value of Neutrophil to Lymphocyte Ratio in Outcomes of Patients with Acute Coronary Syndrome. Arch Med Res 41(8):618–622

45.

Tasoglu O, Boluk H, Onat SS, Tasoglu I, Ozgirgin N (2016) Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity? Clin Rheumatol 35(6):1579–1583CrossRefPubMed

Titel: A novel biomarker in patients with knee osteoarthritis: adropin
verfasst von: Gulsah Gundogdu
Koksal Gundogdu
Publikationsdatum: 16.03.2018
Verlag: Springer London
Erschienen in: Clinical Rheumatology / Ausgabe 8/2018
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-018-4052-z

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

16.04.2024 | Spondylitis ankylosans | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

A novel biomarker in patients with knee osteoarthritis: adropin

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Sind Betablocker auch für ältere herzschwache Personen nützlich?

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Manche Gestagene können das Risiko für Meningeome erhöhen

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2018

Differences in clinical Pneumocystis pneumonia in rheumatoid arthritis and other connective tissue diseases suggesting a rheumatoid-specific interstitial lung injury spectrum

Differences in daily objective physical activity and sedentary time between women with self-reported fibromyalgia and controls: results from the Canadian health measures survey

Serum calprotectin may reflect inflammatory activity in patients with active rheumatoid arthritis despite normal to low C-reactive protein

Influence of autoimmunity and inflammation on endothelial function and thrombosis in systemic lupus erythematosus patients

Oral cyclophosphamide in treatment of patients with refractory idiopathic inflammatory myopathies: a retrospective observational study

Ultrasound-guided synovial biopsy improves diagnosis of septic arthritis in acute arthritis without enough analyzable synovial fluid: a retrospective analysis of 176 arthritis from a French rheumatology department

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Vorsicht mit hohen NSAR-Dosen bei ankylosierender Spondylitis!

Sind Betablocker auch für ältere herzschwache Personen nützlich?

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Manche Gestagene können das Risiko für Meningeome erhöhen

Update Innere Medizin