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Erschienen in: Lasers in Medical Science 7/2018

09.06.2018 | Original Article

A novel Met-IR-782 near-infrared probe for fluorescent imaging-guided photothermal therapy in breast cancer

verfasst von: Yang Wu, Wei Zhang, Di Xu, Li Ding, Rong Ma, Jian-Zhong Wu, Jin-Hai Tang

Erschienen in: Lasers in Medical Science | Ausgabe 7/2018

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Abstract

In this work, a novel photothermal agent based on methionine (Met) was synthesized, which shows strong absorbance in the near infrared ray (NIR) region and is available for NIR imaging and in vivo photothermal therapy in a mouse model. Comparing to free IR-782, the obtained Met modified fluorescent dye (Met-IR-782) exhibited excellent fluorescence stability, preferable photothermal conversion efficiency under 780 nm laser irradiation and specific targeting to MCF7 (human breast adenocarcinoma cell line) cells. The fluorescence imaging ability enabled in situ monitoring of the tumor accumulation of Met-IR-782. The photothermal cytotoxicity assays in vitro and photothermal therapy treatments in vivo indicated that Met-IR-782 could efficiently target and suppress the growth of MCF7 xenograft tumors. Hence, Met-IR-782 is a potential fluorescent agent for NIR imaging-guided cancer photothermal therapy in clinical application. This work highlights the prospect of using light absorbing agents for NIR imaging-guided photothermal therapy.
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Metadaten
Titel
A novel Met-IR-782 near-infrared probe for fluorescent imaging-guided photothermal therapy in breast cancer
verfasst von
Yang Wu
Wei Zhang
Di Xu
Li Ding
Rong Ma
Jian-Zhong Wu
Jin-Hai Tang
Publikationsdatum
09.06.2018
Verlag
Springer London
Erschienen in
Lasers in Medical Science / Ausgabe 7/2018
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-018-2532-7

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