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01.12.2018 | Perspective | Ausgabe 1/2018 Open Access

Clinical and Translational Medicine 1/2018

A perspective on multi-target drug discovery and design for complex diseases

Zeitschrift:
Clinical and Translational Medicine > Ausgabe 1/2018
Autoren:
Rona R. Ramsay, Marija R. Popovic-Nikolic, Katarina Nikolic, Elisa Uliassi, Maria Laura Bolognesi

Abstract

Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative factors. Modern drug discovery has the power to identify potential modulators for multiple targets from millions of compounds. Computational approaches allow the determination of the association of each compound with its target before chemical synthesis and biological testing is done. These approaches depend on the prior identification of clinically and biologically validated targets. This Perspective will focus on the molecular and computational approaches that underpin drug design by medicinal chemists to promote understanding and collaboration with clinical scientists.
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