A phase II study of adaptive two-step intensity-modulated radiation therapy (IMRT) with chemotherapy for loco-regionally advanced nasopharyngeal cancer (JCOG1015)
- 27.03.2020
- Original Article
Erschienen in:
- Verfasst von
- Yasumasa Nishimura
- Satoshi Ishikura
- Taro Shibata
- Takeshi Kodaira
- Yoshinori Ito
- Kazuhiko Tsuchiya
- Yuji Murakami
- Jun-ichi Saitoh
- Tetsuo Akimoto
- Kensei Nakata
- Michio Yoshimura
- Teruki Teshima
- Takashi Toshiyasu
- Yosuke Ota
- Kazuki Ishikawa
- Hidetoshi Shimizu
- Toshiyuki Minemura
- Kenichi Nakamura
- Masahiro Hiraoka
- Erschienen in
- International Journal of Clinical Oncology | Ausgabe 7/2020
Abstract
Background
A phase II study of adaptive two-step intensity-modulated radiotherapy (IMRT) with chemotherapy for nasopharyngeal cancer (NPC) (JCOG1015) was conducted to evaluate the efficacy and safety.
Methods
Patients aged 20–75 years with stages II–IVB NPC were enrolled. As adaptive two-step IMRT, computed tomography planning was performed twice before IMRT for the initial plan of 46 Gy/23 fractions and during treatment for the boost plan of 24 Gy/12 fractions with a total dose of 70 Gy. Chemotherapy (cisplatin 80 mg/m2/3-weeks × 3 courses) was administered concurrently with IMRT, followed by adjuvant chemotherapy (cisplatin at 70 mg/m2 with 5-FU 700 at mg/m2 for 5 days/4 weeks × 3 courses).
Results
Between 2011 and 2014, 75 patients were enrolled from 12 institutions. The 3-year overall survival (OS) for the 75 patients was 88%, and the upper and lower limits of the 95% CI of 78%–94% were higher than the expected 3-year OS of 75% for the target population adjusted by the actual proportion of stage II:III:IV = 21%:44%:35%. The 3-year progression-free survival (PFS) and loco-regional PFS were 71% [59–80%] and 77% [66–85%], respectively. Although no grade 4–5 late toxicities were observed, 15 patients (20%) developed grade 3 late toxicities. Grade 2 xerostomia was noted in 26%, 12%, and 9% at 1, 2, and 3 years after starting IMRT, respectively.
Conclusions
Adaptive two-step IMRT for NPC demonstrated an excellent 3-year OS with acceptable toxicities. This method may be one treatment option for locally advanced NPC.
Anzeige
- Titel
- A phase II study of adaptive two-step intensity-modulated radiation therapy (IMRT) with chemotherapy for loco-regionally advanced nasopharyngeal cancer (JCOG1015)
- Verfasst von
-
Yasumasa Nishimura
Satoshi Ishikura
Taro Shibata
Takeshi Kodaira
Yoshinori Ito
Kazuhiko Tsuchiya
Yuji Murakami
Jun-ichi Saitoh
Tetsuo Akimoto
Kensei Nakata
Michio Yoshimura
Teruki Teshima
Takashi Toshiyasu
Yosuke Ota
Kazuki Ishikawa
Hidetoshi Shimizu
Toshiyuki Minemura
Kenichi Nakamura
Masahiro Hiraoka
- Publikationsdatum
- 27.03.2020
- Verlag
- Springer Singapore
- Erschienen in
-
International Journal of Clinical Oncology / Ausgabe 7/2020
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772 - DOI
- https://doi.org/10.1007/s10147-020-01665-2
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
