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01.12.2014 | Original Article | Ausgabe 4/2014

Familial Cancer 4/2014

A polymorphism at miRNA-122-binding site in the IL-1α 3′UTR is associated with risk of epithelial ovarian cancer

Zeitschrift:
Familial Cancer > Ausgabe 4/2014
Autoren:
Zhu Zhang, Bin Zhou, Qianqian Gao, Yuke Wu, Kui Zhang, Yan Pu, Yaping Song, Lin Zhang, Mingrong Xi
Wichtige Hinweise
Zhu Zhang, Bin Zhou, Qianqian Gao, Yuke Wu, Yaping Song, Lin Zhang and Mingrong Xi have contributed equally to the work and each is considered first author.
Zhu Zhang and Bin Zhou have contributed equally to the work.

Abstract

We aimed to investigate the association between rs3783553 polymorphism and susceptibility to epithelial ovarian cancer in a Chinese population and discussed the risk factors associated with survival time. In a case–control study, 301 patients diagnosed with epithelial ovarian cancer and 240 healthy controls were genotyped for rs3783553 polymorphism. Survival time of ovarian cancer patients was explored by Kaplan–Meier analysis and Cox proportional hazards modeling. The distributions of genotype and allele frequencies were significantly different between cases and controls. The variant homozygote (ins/ins) was associated with a significantly reduced risk of ovarian cancer. The patients with del/ins polymorphism seemed to be diagnosed “earlier” (FIGO stage I–II) and be more likely to achieve optimal cytoreductive surgery. Advanced FIGO stage (stages III–IV) and non-optimal cytoreductive surgery (residual tumor <1 cm) were poor prognostic factors in the univariate analysis. However, optimal cytoreductive surgery was found to be the only independent significant prognostic factor. This study suggests that rs3783553 polymorphism may be involved in the susceptibility to epithelial ovarian cancer. It may also be related with the tumor stage and the ability to achieve optimal tumor surgery, while the latter predicts the clinical outcomes for patients as the only independent prognostic factor.

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