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Journal of Cancer Research and Clinical Oncology

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01.09.2009 | Original Paper

A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

verfasst von: Petra Willems, Kim De Ruyck, Rudy Van den Broecke, Amin Makar, Gianpaolo Perletti, Hubert Thierens, Anne Vral

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 9/2009

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Abstract

Purpose

Polymorphisms in double strand break repair genes could be involved in genetic breast cancer predisposition as enhanced chromosomal radiosensitivity is a hallmark for breast cancer. Previously, the c.-1310 C>G SNP, located in the Ku70 promoter, showed a significant odds ratio (OR) of 1.85 (P = 0.048) in sporadic, but not familial breast cancer patients, indicating that other factors besides genetic aptitude influence this association. As breast epithelium is exposed to endogenous oxidative stress through oestrogen exposure, the influence of hormone exposure was further examined.

Methods and results

A significant OR (1.69, P = 0.017) was found for an enlarged patient population through PCR-RFLP assays in a case–control study in a Belgian population. After dividing the patient population according to oestrogen exposure, high and significant ORs were seen for patients with a longer oestrogen exposure (late age at menopause: OR = 1.96, P = 0.029).

Conclusion

These results show that the variant allele of c.-1310 C>G, located in the Ku70 promoter, is a risk allele for breast cancer. Furthermore, the association of the c.-1310 C>G SNP with breast cancer risk was stronger in women with a long oestrogen exposure.

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Titel: A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure
verfasst von: Petra Willems
Kim De Ruyck
Rudy Van den Broecke
Amin Makar
Gianpaolo Perletti
Hubert Thierens
Anne Vral
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 9/2009
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-009-0556-x

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A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

Abstract

Purpose

Methods and results

Conclusion

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