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Surgery Today
Erschienen in: Surgery Today 3/2019

31.10.2018 | Original Article

A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts

verfasst von: Akimitsu Tanio, Hiroaki Saito, Chihiro Uejima, Seigo Takaya, Manabu Yamamoto, Naruo Tokuyasu, Teruhisa Sakamoto, Soichiro Honjo, Keigo Ashida, Yoshiyuki Fujiwara

Erschienen in: Surgery Today | Ausgabe 3/2019

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Abstract

Purpose

Associations between the preoperative absolute neutrophil count (NC), lymphocyte count (LC), and monocyte count (MC) in the peripheral blood and the prognosis of colorectal cancer (CRC) patients have not been widely studied.

Methods

We enrolled 361 patients who underwent surgery for CRC between January 2007 and December 2013 to analyze correlations among the LC, MC, and NC and prognosis.

Results

Based on cut-off values determined by a receiver operating characteristic analysis, patients were subgrouped as LymphHigh or LymphLow (cut-off: LC = 1460 cells/µL); as MonoHigh or MonoLow (cut-off: MC = 421 cells/µL); and as NeutHigh or NeutLow (cut-off: NC = 3247 cells/µL). Patients were then given lymphocyte–monocyte–neutrophil (LMN) scores by adding the points of their different subgroups (1 point each for LymphLow, MonoHigh and NeutHigh; 0 points for LymphHigh, MonoLow and NeutLow). The 5-year overall survival rates significantly differed by the LMN score (0: 89.7%, 1: 80.6%, 2: 68.8%, and 3: 57.4%; P < 0.0001). In the multivariate analysis, the LMN score was found to be an independent prognostic indicator.

Conclusions

The combination of the preoperative absolute number of lymphocytes, monocytes, and neutrophils is a useful prognostic indicator in CRC patients.
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Metadaten
Titel
A prognostic index for colorectal cancer based on preoperative absolute lymphocyte, monocyte, and neutrophil counts
verfasst von
Akimitsu Tanio
Hiroaki Saito
Chihiro Uejima
Seigo Takaya
Manabu Yamamoto
Naruo Tokuyasu
Teruhisa Sakamoto
Soichiro Honjo
Keigo Ashida
Yoshiyuki Fujiwara
Publikationsdatum
31.10.2018
Verlag
Springer Singapore
Erschienen in
Surgery Today / Ausgabe 3/2019
Print ISSN: 0941-1291
Elektronische ISSN: 1436-2813
DOI
https://doi.org/10.1007/s00595-018-1728-6

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