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Erschienen in:

11.11.2020 | Sarcoma

A Prospective Observational Study of Multivisceral Resection for Retroperitoneal Sarcoma: Clinical and Patient-Reported Outcomes 1 Year After Surgery

verfasst von: Marco Fiore, MD, FACS, Cinzia Brunelli, MSc, Rosalba Miceli, PhD, Michele Manara, MD, Susanna Lenna, MD, Nicolò N. Rampello, RN, Dario Callegaro, MD, Chiara Colombo, MD, Stefano Radaelli, MD, Sandro Pasquali, PhD, MD, Augusto T. Caraceni, MD, Alessandro Gronchi, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 7/2021

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Abstract

Background

Primary retroperitoneal sarcoma (RPS) may require multivisceral resection (MVR). Clinical outcome (morbidity and renal function) and quality of life (QoL) are not as well reported as the oncologic outcome.

Methods

Patients with primary RPS who underwent surgery between 2014 and 2016 were prospectively enrolled in an observational longitudinal study. At baseline, then at 4 and 12 months, the study measured Clavien–Dindo morbidity, estimated glomerular filtration rate (EGFR), EORTC QLQ-C30, QLQ-CR29, DN4 (neuropathic pain [NP]), lower-extremity functional scale (LEFS), and the brief pain inventory. The primary end point was the difference in global health status (GHS/QoL). The secondary end points were EGFR changes, difference in other QLQ-C30 scales, pain intensity, NP, and LEFS. The study is registered at ClinTrials.gov (NCT03480399).

Results

Of 74 patients, 58 were evaluable. Morbidity grade 3 or higher was 24.1%, and mortality was 1.3%. After nephrectomy, the mean 1-year EGFR change was −33.9%. The GHS/QoL at baseline was 58.6 and had increased of 6.9 points at 1 year, comparable with that of the general population. A transient worsening in pain and diarrhea had recovered at 12 months. Average pain was mild and did not differ at 12 months. However, NP was found in 41.4% of the patients and was significantly associated with resection of the psoas muscle. At baseline, LEFS was already lower than the normative value, and worsening after surgery was not clinically relevant.

Conclusion

A QoL measure after MVR in primary RPS is complex and requires multiple tools. Whereas overall MVR is safe and associated with an improvement in GHS/QoL, chronic NP is frequent and deserves specific attention. Pre-surgery rehabilitation tracks may help to prevent or reduce chronic NP.
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Metadaten
Titel
A Prospective Observational Study of Multivisceral Resection for Retroperitoneal Sarcoma: Clinical and Patient-Reported Outcomes 1 Year After Surgery
verfasst von
Marco Fiore, MD, FACS
Cinzia Brunelli, MSc
Rosalba Miceli, PhD
Michele Manara, MD
Susanna Lenna, MD
Nicolò N. Rampello, RN
Dario Callegaro, MD
Chiara Colombo, MD
Stefano Radaelli, MD
Sandro Pasquali, PhD, MD
Augusto T. Caraceni, MD
Alessandro Gronchi, MD
Publikationsdatum
11.11.2020
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 7/2021
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-020-09307-7

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